Results 51 to 60 of about 154,777 (303)

Toll like receptor 2 and 4 expression in peripheral blood mononuclear cells of multiple sclerosis patients [PDF]

, 2014
Background: Multiple sclerosis (MS) is a T cell mediated autoimmune disease with unknown etiology. Appropriate MS therapeutic strategies need thorough understanding of both disease etiology and pathogenesis mechanisms.
Hasheminia, Seyed Javad., Hashemzadeh-Chaleshtori, Morteza., Shaygannejad, Vahid., shirzad, Hedayatollah., Tolouei, Sepideh., Zarkesh Esfahani, Hamid.   +5 more
core  

Modulation of Host Immunity by Human Respiratory Syncytial Virus Virulence Factors: A Synergic Inhibition of Both Innate and Adaptive Immunity [PDF]

, 2017
Indexación: Web of Science; Scopus.The Human Respiratory Syncytial Virus (hRSV) is a major cause of acute lower respiratory tract infections (ARTIs) and high rates of hospitalizations in children and in the elderly worldwide.
Alexis M. Kalergis, Alexis M. Kalergis, Claudia A. Riedel, Emma Rey-Jurado, Gisela Canedo-Marroquín, Juan M. Saavedra, Margarita K. Lay, Margarita K. Lay, Orlando Acevedo-Acevedo, Susan M. Bueno   +9 more
core   +2 more sources

Aggregation Behavior of an Ultra-Pure Lipopolysaccharide that Stimulates TLR-4 Receptors [PDF]

Biophysical Journal, 2008
The innate immune systems of humans and other animals are activated by lipopolysaccharides (LPS), which are glucosamine-based phospholipids that form the outer leaflet of the outer membranes of Gram-negative bacteria. Activation involves interactions of LPS with the innate immunity-receptor comprised of toll-like receptor 4 in complex with so-called MD-
Sasaki, Hirotaka, White, Stephen H
openaire   +3 more sources

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

The Effect of TLR4 Asp299Gly polymorphism on IL-6 and IL -18 expression in H.pylori infected patients [PDF]

Journal of Kerman University of Medical Sciences, 2016
Background & Aims: Helicobacter pylori (H. pylori) infection is associated with peptic ulcer and gastric cancer. Polymorphisms of the genes coding Toll-like receptors (TLRs) may influence the innate and adaptive immune responses and affect the ...
Ghorbanali Rahimian, Nader Bagheri, Abolfazl Gholipour, Hedayatollah Shirzad   +3 more
doaj  

Increased levels of hyaluronic acid in bronchoalveolar lavage from patients with interstitial lung diseases, relationship with lung function and inflammatory cells recruitment [PDF]

, 2014
Purpose: Interstitial Lung Diseases (ILD) are characterized by inflammation and fibrosis. It described the role of hyaluronic acid (HA) as an immune-regulator. It is not known if HA contributes to the recruitment of inflammatory cells associated with ILD.
Auteri, Santiago, Ernst, Glenda, Galíndez, Fernando, Grynblat, Pedro, Hajos, Silvia Elvira, Jancic, Carolina Cristina, Rodriguez Moncalvo, Juan   +6 more
core   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Effects of Toll-Like Receptors 3 and 4 in the Osteogenesis of Stem Cells

Stem Cells International, 2014
Objective. To investigate the effects of Toll-like receptors in stem cell osteogenesis. Methods. Bone marrow mesenchymal stem cells (BMSCs) were divided into the blank group, the TLR-3 activated group, and the TLR-4 activated group.
Chen Qi, Xu Xiaofeng, Wang Xiaoguang
doaj   +1 more source

Cellular actors, Toll-like receptors, and local cytokine profile in acute coronary syndromes [PDF]

, 2017
Aims Inflammation plays a key role in acute coronary syndromes (ACS). Toll-like receptors (TLR) on leucocytes mediate inflammation and immune responses.
Altwegg, Lukas, Amann-Vesti, Beatrice, Corti, Roberto, Eberli, Franz R., Gay, Steffen, Kucher, Nils, Lüscher, Thomas F., Maier, Willibald, Neidhart, Michel, Roffi, Marco, Spanaus, Katharina S., von Eckardstein, Arnold, Wischnewsky, Manfred B., Wyss, Christophe A., Yonekawa, Keiko   +14 more
core  

Enhanced Human Antigen‐Specific B Cell Responses Using In Vitro 3D Tonsil Cultures Containing Stromal Cells

Advanced Healthcare Materials, EarlyView.
We developed a fully human 3D tonsil cell culture system incorporating supportive stromal cells that better sustains and activates immune cells than conventional methods. The model generates stronger, more targeted antibody responses to viral antigens and vaccines, providing a physiologically relevant and entirely human platform for studying immune ...
Maaike V. J. Braham, Marlon de Gast, Liubov Babii, Sabine Kruijer, Theo M. Bestebroer, Mathilde Richard, Mathieu Claireaux, S. Marieke van Ham, Jelle de Wit, Cécile A. C. M. van Els, Anja ten Brinke, Marit J. van Gils   +11 more
wiley   +1 more source