Results 51 to 60 of about 17,805,524 (287)

Evidence for dissociation of TLR mRNA expression and TLR agonist-mediated functions in bovine macrophages

, 2006
Toll-like receptors are of key importance in the recognition of and response to infectious agents by cells of the innate immune system. TLR mRNA expression and TLR-mediated functions were determined in bovine macrophages (MPhi) infected with bovine viral
Sauter, Kay-Sara, Franchini, Marco, Schweizer, Matthias, Peterhans, Ernst, Jungi, Thomas W, Mirkovitch, Jelena, Mätzener, Philippe, Magkouras, Ioannis   +7 more
core   +1 more source

Efficacy of specific prevention of influenza in individuals with polymorphisms Arg753Gln of TLR-2, Leu412Phe of TLR-3, Asp299gly of TLR-4 genes

, 2020
The aim: is to study the efficacy of influenza vaccination for individuals with polymorphism Arg753Gln of TLR-2 gene, Leu412Phe of TLR-3 gene, and Asp299Gly of TLR-4 gene. Materials and methods: 66 people with mutant genotypes and normal distribution of
Pryimenko, N. O., Руденко, Станіслав Станіславович, Kotelevska, T. M., Syzova, L. M., Боднар, Вадим Анатолійович, Koval, T. I., Котелевська, Тетяна Михайлівна, Rudenko, S. S., Прийменко, Наталія Олегівна, Коваль, Тетяна Ігорівна, Bodnar, V. A., Сизова, Людмила Михайлівна   +11 more
core   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

MG53 Coordinates Macrophage Polarization and Neuroimmune Coupling to Promote Corneal Nerve Regeneration via the MPEG1–MVP–STAT6 Axis

Advanced Science, EarlyView.
Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...
Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Luxi Zhang, Han Ye, William Sollenberger, Takahide Ikeda, Zhiyu Yan, Keerthika Sathish, Usman Alizai, Haitao Wen, Timothy M. Pawlik, Heather L. Chandler, Hua Zhu   +14 more
wiley   +1 more source

The role of TLR-2, TLR-3, TLR-4 genes polymorphism in case of grippe

, 2014
В данной статье изучены распространенность и прогностическое значение полиморфизма Arg753Gln гена TLR-2, Leu412Phe TLR-3, Asp299Gly TLR-4 при гриппе.
Кайдашев, Игорь Петрович, Чуб, Костянтин Федорович, Dubynska, G., Похилько, Валерий Иванович, Прийменко, Наталія Олегівна, Дубинська, Галина Михайлівна, Pryimenko, N. O., Chub, K. F., Чуб, Константин Федорович, Kaidashev, I., Pokhylko, V. I., Прийменко, Наталья Олеговна, Кайдашев, Ігор Петрович, Дубинская, Галина Михайловна, Похилько, Валерій Іванович   +14 more
core   +1 more source

ОСОБЛИВОСТІ ПРЕМОРБІДНОГО ФОНУ ТА ПЕРЕБІГУ ПНЕВМОНІЙ ПРИ ГРИПІ В ОСІБ ІЗ ПОЛІМОРФІЗМОМ ГЕНІВ TLR-2, TLR-3, TLR-4

, 2013
Проаналізовано преморбідний фон і перебіг грипу, ускладненого пневмонією, у пацієнтів із поліморфізмом Arg753Gln гену TLR-2, Leu412Phe гену TLR-3, Asp299Gly гену TLR-4.
Прийменко, Н.О.
core   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Patterns of milk productivity associated with biochemical parameters and expressions of the HSPs and Toll Like genes in dairy buffaloes

Medicina Veterinária
The aim of this study was to verify milk productivity associated with biochemical parameters and expression of stress marker genes (HSP70, HSP90?, HSP90?) and immunity (TLR-2 and TLR-4) in dairy buffaloes.
Henrique Low Nogueira, Elem Cristina Macedo Barra de Sousa, Cintia Luana Pinheiro Santos, Ednaldo Silva Filho, Priscila Di Paula Bessa Santana   +4 more
doaj   +5 more sources

Toll-Like Receptor-1 and Receptor-2 and Beta-Defensin in Postcholecystectomy Bile Duct Injury

Gastroenterology Research and Practice, 2015
Postcholecystectomy bile duct injuries (BDI) produce hepatic cholestasis and cause infection of the biliary tract. The biliary cells participate in secreting cytokines and in expression of immune response receptors.
Alejandra Guillermina Miranda-Díaz, José Manuel Hermosillo-Sandoval, Martha Arisbeth Villanueva-Pérez, Luis Miguel Román-Pintos, Trinidad García-Iglesias, Adolfo Daniel Rodríguez-Carrizalez, Ernesto Germán Cardona-Muñoz   +6 more
doaj   +1 more source