Results 61 to 70 of about 17,805,524 (287)

Polyethylene wear particles induce TLR 2 upregulation in the synovial layer of mice

Journal of Materials Science: Materials in Medicine, 2013
A cellular and receptor mediated response to ultra-high-molecular-weight-polyethylene (UHMWPE) wear particles results in a release of proinflammatory cytokines and induces an inflammatory reaction causing osteolysis in total joint replacement. This investigation offers insight into the toll-like receptor (TLR) mediated activation by polyethylene wear ...
A C, Paulus, J, Frenzel, A, Ficklscherer, B P, Roßbach, C, Melcher, V, Jansson, S, Utzschneider   +6 more
openaire   +2 more sources

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

The role of TLR-2, TLR-4 and MyD88 in the development of experimental autoimmune diabetes.

, 2013
O diabetes mellitus tipo 1 (DMT1) é uma doença autoimune caracterizada pela destruição das células b pancreáticas, por citocinas (IFN-g, IL-1b, e TNF-a) produzidas por macrófagos e linfócitos Th1.
Carla Sandrina Rendall Moreira Sá, Sá, Carla Sandrina Rendall Moreira   +1 more
core   +1 more source

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

Placental Trophoblast Responses to Porphyromonas gingivalis Mediated by Toll-like Receptor-2 and -4

Journal of Dentistry Indonesia, 2013
Trophoblast participates in preventing allorecognition and controlling pathogens that compromise fetal wellbeing. Toll-like receptors recognize conserved sequences on the pathogens surface and trigger effector cell functions.
Banun Kusumawardani, Marsetyawan HNE Soesatyo, Djaswadi Dasuki, Widya Asmara   +3 more
doaj   +1 more source

Trichinella spiralis galectin binding to toll-like receptor 4 induces intestinal inflammation and mediates larval invasion of gut mucosa

Veterinary Research, 2023
Previous studies showed that Trichinella spiralis galectin (Tsgal) facilitates larval invasion of intestinal epithelium cells (IECs). However, IEC proteins binding with Tsgal were not identified, and the mechanism by which Tsgal promotes larval invasion ...
Kai Ning Ma, Yao Zhang, Zhao Yu Zhang, Bo Ning Wang, Yan Yan Song, Lu Lu Han, Xin Zhuo Zhang, Shao Rong Long, Jing Cui, Zhong Quan Wang   +9 more
doaj   +1 more source

Overexpression of proinflammatory TLR-2-signalling lipoproteins in hypervirulent mycobacterial variants.

Cellular microbiology, 2011
Changes in the cell envelope composition of mycobacteria cause major changes in cytokine profiles of infected antigen presenting cells. We describe here the modulation of inflammatory responses by Mycobacterium abscessus, an emerging pathogen in cystic fibrosis. M. abscessus is able to switch from a smooth (S) to a rough (R) morphotype by the loss of a
Roux, Anne-Laure, Ray, Aurélie, Pawlik, Alexandre, Medjahed, Halima, Etienne, Gilles, Rottman, Martin, Catherinot, Emilie, Coppée, Jean-Yves, Chaoui, Karima, Monsarrat, Bernard, Toubert, Antoine, Daffé, Mamadou, Puzo, Germain, Gaillard, Jean-Louis, Brosch, Roland, Dulphy, Nicolas, Nigou, Jérôme, Herrmann, Jean-Louis   +17 more
openaire   +3 more sources

Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice

PLoS Biology, 2011
Environmental factors and host genetics interact to control the gut microbiota, which may have a role in the development of obesity and insulin resistance. TLR2-deficient mice, under germ-free conditions, are protected from diet-induced insulin resistance.
Andréa M Caricilli, Paty K Picardi, Lélia L de Abreu, Mirian Ueno, Patrícia O Prada, Eduardo R Ropelle, Sandro Massao Hirabara, Ângela Castoldi, Pedro Vieira, Niels O S Camara, Rui Curi, José B Carvalheira, Mário J A Saad   +12 more
openaire   +4 more sources

Severity of histological staging of chorioamnionitis correlates with expression of TLR 1 and TLR 2.

, 2015
This figure shows the relationship between expression of TLR 1 and TLR 2 in the chorion and staging of maternal (4a) and fetal (4b) inflammation. Least squares linear regression was used. All samples staged via Redline criteria included.
Gareth J. Waring (737824), Stephen C. Robson (737825), Judith N. Bulmer (737826), Alison J. Tyson-Capper (111314)   +3 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source