Results 61 to 70 of about 137,836 (151)

Polymorphic variants of the TLR 2 gene in syphilis [PDF]

Medical news of the North Caucasus, 2017
Lyudmila Barycheva, Milana Minasyan, Vyacheslav Chebotarev, Alexey Odinets   +3 more
openaire   +1 more source

Exploring the Impact of TLR‐2 Signaling on miRNA Dysregulation in Intervertebral Disc Degeneration

Advanced Biology
AbstractToll‐like receptors (TLRs) are key mediators of inflammation in intervertebral disc (IVD) degeneration. TLR‐2 activation contributes to the degenerative process by increasing the expression of extracellular matrix‐degrading enzymes, pro‐inflammatory cytokines, and neurotrophins.
Petra Cazzanelli, Mikkael Lamoca, Oliver Nic Hausmann, Addisu Mesfin, Varun Puvanesarajah, Wolfgang Hitzl, Lisbet Haglund, Karin Wuertz‐Kozak   +7 more
openaire   +2 more sources

Differential regulation of monocyte exhaustion by distinct TLR agonists and underlying mechanisms

Cell Communication and Signaling
Monocyte exhaustion is a dysfunctional immune state marked by persistent inflammation and immune suppression, reflected in STAT1-mediated expression of pathogenic inflammatory mediator CD38 and immune suppressive PD-L1, as well as a suppression of Akt ...
Jing Wang, Yajun Wu, Grace Lee, Babak Razani, Liwu Li   +4 more
doaj   +1 more source

Bacterial extract cantastim activates macrophages via TLR-2.

Roumanian archives of microbiology and immunology, 2011
CANTASTIM is a second generation bacterial immunomodulator. The aim of this study was to examine the mechanism by which bacterial immunomodulator CANTASTIM induces production of inflammatory cytokines in monocytes/macrophages. Proinflammatory cytokines were induced in PMA-differentiated THP-1 cells by stimulation with TLR agonists and CANTASTIM in the ...
Iuliana, Caraş, Cătălin, Tucureanu, Ramona, Pitica, Aurora, Sălăgeanu   +3 more
openaire   +1 more source

بررسی تأثیر ابتلا به پریودنتیت مزمن بر میزان بیان ژن TLR-2 و TLR-4 در بافت لثه ای [PDF]

Journal of Mashhad Dental School, 2011
مقدمه: در عفونت‏های پریودنتال پیش نیاز شروع پاسخ‏های میزبان، شناخت پاتوژن‏‏ها توسط سیستم ایمنی میزبان می‏باشد. خانواده رسپتور‏های Toll-like (TLRs)، مسئول شناسایی ساختار‏های حفظ شده میکروبیال نظیر لیپوپلی ساکارید (LPS) باکتری‏ها می‏باشند و مسیر‏های سیگنال
کاظم فاطمی, مهرداد رادور, عبدالرحیم رضایی, حمیدرضا عرب, هوشنگ رفعت پناه, حسن آذان گو خیاوی, یلدا دادپور   +6 more
doaj  

Relationship between TLR-2 level and clinical or radiological severity on patients with tuberculosis spondylitis in Dr. Wahidin Sudirohusodo hospital Makassar. [PDF]

Medicine (Baltimore), 2023
Arifin J, Saleh MR, Argo RS, Kennedy D, Usman MA, Singjie LC.   +5 more
europepmc   +1 more source

Targeting dendritic cells with TLR-2 ligand-coated nanoparticles loaded with Mycobacterium tuberculosis epitope induce antituberculosis immunity. [PDF]

J Biol Chem, 2022
Kumar Das D, Zafar MA, Nanda S, Singh S, Lamba T, Bashir H, Singh P, Maurya SK, Nadeem S, Sehrawat S, Bhalla V, Agrewala JN.   +11 more
europepmc   +1 more source

支气管肺泡灌洗液及血清NF-κB、TLR-2、TLR-4、 TNF-α在肺炎诊断中的应用价值

Zhongguo shiyan zhenduanxue
目的 探讨支气管肺泡灌洗液(BALF)及血清核转录因子-κB(NF-κB)、Toll样受体2(TLR-2)、Toll样受体4(TLR-4)、肿瘤坏死因子α(TNF-α)在肺炎诊断中的应用价值。方法 选取2023年1月—2024年3月于吉林大学第二医院就诊的57例肺炎患者纳入研究组，另取同期体检的健康者57例纳入对照组，均采集外周静脉血与肺泡灌洗液，检测NF-κB、TLR-2、TLR-4、TNF-α水平，采用Pearson相关性分析患者血清及BALF中NF-κB、TLR-2、TLR-4、TNF-α的相关性。
金美玉, 王冠, 林文婷, 吴艳峰
doaj  

Gardnerella vaginalis induces matrix metalloproteinases in the cervicovaginal epithelium through TLR-2 activation. [PDF]

J Reprod Immunol, 2022
Gerson KD, Anton L, Ferguson B, Ravel J, Burris HH, Elovitz MA.   +5 more
europepmc   +1 more source

The novel hyaluronic acid granular hydrogel attenuates osteoarthritis progression by inhibiting the TLR-2/NF-κB signaling pathway through suppressing cellular senescence. [PDF]

Bioeng Transl Med, 2023
Zhang C, Cheng Z, Zhou Y, Yu Z, Mai H, Xu C, Zhang J, Wang J.   +7 more
europepmc   +1 more source