Results 81 to 90 of about 150,598 (283)

Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice

PLoS Biology, 2011
Environmental factors and host genetics interact to control the gut microbiota, which may have a role in the development of obesity and insulin resistance. TLR2-deficient mice, under germ-free conditions, are protected from diet-induced insulin resistance.
Andréa M Caricilli, Paty K Picardi, Lélia L de Abreu, Mirian Ueno, Patrícia O Prada, Eduardo R Ropelle, Sandro Massao Hirabara, Ângela Castoldi, Pedro Vieira, Niels O S Camara, Rui Curi, José B Carvalheira, Mário J A Saad   +12 more
openaire   +4 more sources

Perspectives on the Trypanosoma cruzi-host cell receptor interaction [PDF]

, 2009
Chagas disease is caused by the parasite Trypanosoma cruzi. The critical initial event is the interaction of the trypomastigote form of the parasite with host receptors. This review highlights recent observations concerning these interactions.
A Belley, A Buschiazzo, AC Frasch, AC Monteiro, AC Monteiro, AG Todorov, AJS Augustine, AK Vaidian, AL Leal, AM Celentano, AM Silber, AM Woolsey, Anthony W. Ashton, AP Lima, AW Ashton, AW Ashton, BA Burleigh, BA Burleigh, BA Burleigh, BK Kubata, C Claser, CA Buscaglia, CA Petersen, CW Turner, E Del Nery, E Ortega-Barria, F Leeb-Lundberg, F Marceau, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, F Villalta, Fabiana S. Machado, Fangxia Guan, Fernando Villalta, GS Hassan, HB Tanowitz, HB Tanowitz, HB Tanowitz, HB Tanowitz, Herbert B. Tanowitz, Huan Huang, IC Cuevas, IM Bastos, J Aliberti, J Scharfstein, J Scharfstein, JC Engel, JL Croxford, JM Di Noia, Julio Scharfstein, K Kabashima, KD Bhoola, Kevin M. Tyler, KJ Simmons, KM Tyler, L Sterin-Borda, LO Andrade, Louis M. Weiss, LX Liu, M de Melo-Jorge, M Einicker-Lamas, M Ming, MA Campos, MA Ouaissi, Maria F. Lima, MC Taylor, ME McGrath, MF Lima, MF Lima, MH Magdesian, MJ Alves, MN Meirelles, MV Chuenkova, MV Chuenkova, MV Chuenkova, MV Chuenkova, N Garg, N Garg, N Yoshida, P Grellier, PJ Pereira, PN Nde, R Agusti, R Giordano, R Manning-Cela, RA Skidgel, RL Cardoni, S Favoreto Jr, S Mukherjee, S Mukherjee, S Mukherjee, S Schenkman, S Vaena de Avalos, Sandra Alvarez, SB Petkova, SB Petkova, SG Andrade, Shankar Mukherjee, SM Factor, T Moody, VL Hideko Tatakihara, YY Kleshchenko   +108 more
core   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

Effective squeezing enhancement via measurement-induced non-Gaussian operation and its application to dense coding scheme

, 2005
We study the measurement-induced non-Gaussian operation on the single- and two-mode \textit{Gaussian} squeezed vacuum states with beam splitters and on-off type photon detectors, with which \textit{mixed non-Gaussian} states are generally obtained in the
Kitagawa, Akira, Sasaki, Masahide, Takeoka, Masahiro, Wakui, Kentaro   +3 more
core   +1 more source

Ninjurin 1 contributes to TLR-induced inflammation in endothelial cells [PDF]

, 2012
Background: Nerve injury induced protein 1 (Ninjurin 1 (Ninj1)) was first identified in Schwann cells and neurons contributing to cell adhesion and nerve regeneration.
Jennewein, Carla, Zacharowski, Kai
core   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Ex vivo mRNA expression of toll-like receptors during latent tuberculosis infection

BMC Immunology, 2021
Background Understanding immune mechanisms, particularly the role of innate immune markers during latent TB infection remains elusive. The main objective of this study was to evaluate mRNA gene expression patterns of toll-like receptors (TLRs) as ...
Birhan Alemnew, Soren T. Hoff, Tamrat Abebe, Markos Abebe, Abraham Aseffa, Rawleigh Howe, Liya Wassie   +6 more
doaj   +1 more source

Protein level expression of Toll-like receptors 2, 4 and 9 in renal disease [PDF]

, 2017
Background. Toll-like receptors (TLR) recognize a variety of ligands, including pathogen-associated molecular patterns and link innate and adaptive immunity. Individual receptors can be up-regulated during infection and inflammation.
Batsford, Stephen, Duermueller, Ursula, Hopfer, Helmut, Mihatsch, Michael, Mueller, Christoph, Seemayer, Christian   +5 more
core  

Mycobacterium tuberculosis multi-drug-resistant strain M induces IL-17+ IFNγ- CD4+ T cell expansion through an IL-23 and TGF-β-dependent mechanism in patients with MDR-TB tuberculosis [PDF]

, 2016
We have previously reported that T cells from patients with multidrug-resistant tuberculosis (MDR-TB) express high levels of IL-17 in response to the MDR strain M(Haarlem family) of Mycobacterium tuberculosis (M.tuberculosis).
Balboa, Luciana, Basile, Juan Ignacio, de la Barrera, Silvia Susana, García, A., Gonzalez Montaner, Pablo, Kviatcovsky, Denise, López, Beatriz, Monteserin, Johana, Palmero, Domingo, Ritacco, Gloria Viviana, Romero, María Mercedes, Sabio y García, Carmen Alejandra, Sasiain, María del Carmen, Vescovo, M.   +13 more
core   +2 more sources

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source