Results 71 to 80 of about 17,805,524 (287)

Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis

BMC Gastroenterology, 2010
Background Previously we reported that mice deficient in toll-like receptor 4 (TLR-4) signalling were protected from diet-induced non-alcoholic steatohepatitis (NASH).
Brady Kristen, Pang Jia, Allman Monique, Gaskin LaTausha, Rivera Chantal A, Adegboyega Patrick, Pruitt Kevin   +6 more
doaj   +1 more source

Engineering Oncolytic Virus‐Armed Macrophages for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
ZIFOA‐M is engineered by conjugating oncolytic adenovirus‐loaded ZIF‐8 nanoparticles onto macrophage surfaces via bioorthogonal chemistry. Upon tumor infiltration, the platform releases OA to downregulate CD47/CD24 on tumor cells, restoring macrophage phagocytosis.
Jilong Wang, Ning Lu, Zhuo Yan, Luyi Ye, Luyao Bai, Shanshan Yuan, Yuting Zhu, Yiru Xiong, Yongheng Bai, Yaping Chen, Junjie Deng   +10 more
wiley   +1 more source

Ex vivo mRNA expression of toll-like receptors during latent tuberculosis infection

BMC Immunology, 2021
Background Understanding immune mechanisms, particularly the role of innate immune markers during latent TB infection remains elusive. The main objective of this study was to evaluate mRNA gene expression patterns of toll-like receptors (TLRs) as ...
Birhan Alemnew, Soren T. Hoff, Tamrat Abebe, Markos Abebe, Abraham Aseffa, Rawleigh Howe, Liya Wassie   +6 more
doaj   +1 more source

Assessment of immunological efficacy of specific prevention influenza in persons with polymorphism of TLR-2, TLR-3, TLR-4 genes

, 2014
Метою дослідження було вивчення ефективності вакцинації проти грипу в осіб із поліморфізмом Arg753Gln гену TLR-2, Leu412Phe TLR-3, Asp299Gly TLR-4. Провакциновано 66 осіб із мутантними генотипами та нормальним розподілом алелей TLR-2, TLR-3, TLR-4, віком
Руденко, Станіслав Станіславович, Руденко, Станислав Станиславович, Iziumska, O. M., Артемьева, Елена Владимировна, Artemyeva, Е. V., Dubynska, G., Прийменко, Наталія Олегівна, Дубинська, Галина Михайлівна, Pryimenko, N. O., Ізюмська, Олена Михайлівна, Артемьєва, Олена Володимирівна, Rudenko, S. S., Изюмская, Елена Михайловна, Прийменко, Наталья Олеговна, Дубинская, Галина Михайловна   +14 more
core   +1 more source

Genetic polymorphism Arg753Gln of TLR-2, Leu412Phe of TLR-3, Asp299Gly of TLR-4 in patients with influenza and influenza-associated pneumonia [PDF]

, 2019
The aim of the research is to study the prevalence and to determine the prognostic significance of polymorphism ARG753GLN of the TLR-2 gene, Leu412Phe of TLR-3, Asp299Gly of TLR-4 in influenza.
Pryimenko, N. O., Kotelevska, T. M., Syzova, L. M., Koval, T. I., Котелевська, Тетяна Михайлівна, Kaidashev, I. P., Dubynska, H. M., Прийменко, Наталія Олегівна, Коваль, Тетяна Ігорівна, Дубинська, Галина Михайлівна, Сизова, Людмила Михайлівна, Кайдашев, Ігор Петрович   +11 more
core   +1 more source

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

TLR-2 Arg753Gln, TLR-4 Asp299Gly, and TLR-4 Thr399Ile polymorphisms in Henoch Schonlein purpura with and without renal involvement

, 2010
Infections may trigger or aggravate glomerulonephritidis and renal vasculitis like Henoch Schonlein purpura (HSP). HSP is seen more frequently in patients with familial Mediterranean fever in which TLR-2 Arg753Gln polymorphism frequency is increased ...
CİNGÖZ, SULTAN, Demir, Belde Kasap, SOYLU, ALPER, Sakizli, Meral, Turkmen, Mehmet, KAVUKÇU, SALİH, KIZILDAĞ, SEFA   +6 more
core   +1 more source

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity

Advanced Science, EarlyView.
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li, Xin‐Yuan Zhao, Min Zhang, Zhuang‐Feng Weng, Xiao‐Ran Guo, Ying‐Fang Liu, Qiao‐Ping Wang, Huan‐Huan Liang   +7 more
wiley   +1 more source

Expression of Toll-like receptors 2 and 4 in gingivitis and chronic periodontitis.

Indian Journal of Dental Research, 2006
Periodontal disease is the major cause of adult tooth loss and is commonly characterized by a chronic inflammation caused by infection by oral bacteria.
Sarah S, Tamilselvan S, Kamatchiammal S, Suresh R   +3 more
doaj  

Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes

Advanced Science, EarlyView.
PSTT cells, through cell fusion with B cells, incorporate abundant non‐inherited maternal genes that are detectable by DNIMA. These hybrid cells acquire immunotherapy‐resistant genetic changes and increase the expression of B cell‐derived immune‐related molecules such as Ig, HLA, LILRB, SIGLEC10, and so on, creating an immunotolerant environment around
Kyosuke Kagami, Masanori Ono, Yasunari Mizumoto, Tatsuhito Kanda, Takashi Iizuka, Takiko Daikoku, Shin‐ichi Horike, Akira Hattori, Akihito Horie, Sachiko Minamiguchi, Tomoko Fujiwara, Kazuyoshi Hosomichi, Atsushi Tajima, Hirokazu Usui, Kaoru Abiko, Hiroshi Fujiwara   +15 more
wiley   +1 more source