Results 101 to 110 of about 17,805,524 (287)

ROLE OF INHERENT IMMUNITY AND MICROORGANISMS OF BIOTOPES OF MUCOUS MEMBRANE OF WOMEN’S GENITOURINARY TRACT IN PATHOGENESIS OF CHLAMYDIA INFECTION

Сеченовский вестник, 2010
Aim. Study of Toll-like receptors (TLR) role and microorganisms of bioptopes of genitourinary tract in pathogenesis of genitourinary chlamydiasis.Methods.
M. S. Afanasiev, A. V. Karaulov, V. A. Aleshkin, S. S. Afanasiev, Yu. V. Nesvizhsky, E. A. Voropaeva   +5 more
doaj  

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Functional Toll-Like Receptor (TLR)2 polymorphisms in the susceptibility to inflammatory bowel disease

PLOS ONE, 2017
The recent genome-wide association studies (GWAS) in inflammatory bowel disease (IBD) suggest significant genetic overlap with complex mycobacterial diseases like tuberculosis or leprosy. TLR variants have previously been linked to susceptibility for mycobacterial diseases.
Török, Helga Paula, Bellón, Víctor, Konrad, Astrid, Lacher, Martin, Tonenchi, Laurian, Siebeck, Matthias, Brand, Stephan, de Toni, Enrico Narciso, Kormann, Michael S D   +8 more
openaire   +6 more sources

Genetic prediction of blood cell reactivity and its potential causal influence on bone continuity and density disorders

Animal Models and Experimental Medicine, EarlyView.
We applied Mendelian randomization to explore causal links between blood cell traits and skeletal disorders. Using genetic instruments from large‐scale summary statistics, we assessed effects on bone continuity, density, and structural integrity. Sensitivity and reverse analyses confirmed robust associations, highlighting potential shared biological ...
Zhiqin Deng, Zhe Zhao, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Zhengyang Lin, Zhenhan Deng, Wencui Li   +8 more
wiley   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

The peculiarities of pneumonias course in case of grippe for patients with TLR-2, TLR-3, TLR-4 genes polymorphism

, 2014
Цель - проанализировать течение гриппа, осложненного пневмонией, у пациентов с полиморфизмом генов TLR-2 Arg753Gln, TLR-3 Leu412Phe, TLR-4 Asp299Gly. В исследование были включены 36 пациентов (25 женщин и 11 мужчин) преимущественно молодого и среднего ...
Dubynska, G., Pryimenko, N., Прийменко, Наталія Олегівна, Дубинська, Галина Михайлівна, Прийменко, Наталья Олеговна, Дубинская, Галина Михайловна   +5 more
core  

Chronic alcohol consumption compromises gut barrier integrity and promotes endotoxemia: Implications for sepsis susceptibility in immunocompromised hosts

Animal Models and Experimental Medicine, EarlyView.
Chronic alcohol exposure disrupts intestinal barrier integrity, resulting in a leaky gut and enhanced translocation of lipopolysaccharide (LPS) and microbial products into the systemic circulation. Alcohol‐induced endotoxemia drives exaggerated pro‐inflammatory responses, mitochondrial damage, and activation of the cGAS–STING pathway, particularly in ...
Thansita Bhunyakarnjanarat, Chatsuree Suksamai, Dhammika Leshan Wannigama, Kent Doi, Wiwat Chancharoenthana, Asada Leelahavanichkul   +5 more
wiley   +1 more source

Novel mutations in the toll like receptor genes cause hyporesponsiveness to Mycobacterium avium subsp. paratuberculosis infection

, 2008
Toll like receptors play a central role in the recognition of pathogen associated molecular patterns (PAMPs). Mutations in TLR1, TLR2 and TLR4 genes may change the PAMP reorganization ability which causes altered responsiveness to the bacterial pathogens.
Rostislav Skrabana, Michal Novak, Mangesh Bhide, Ivan Mikula Jr., Rastislav Mucha, Lucia Kisova, Ivan Mikula Sr.   +6 more
core  

TLR-2, TLR-4 and dectin-1 expression.

, 2013
Expression of TLR-2 (A), TLR-4 (B) and dectin-1 (C) on monocytes of fresh and 22 h RPMI-incubated whole blood in subjects exposed to moisture damage (n=25) and subjects not exposed to moisture damage (controls; n=25). Mean relative fluorecence intensity (
Verena Liebers (495173), Stefanie Punsmann (495172), Thomas Brüning (135293), Anne Lotz (495174), Monika Raulf (495175)   +4 more
core   +1 more source