Results 41 to 50 of about 150,598 (283)

Skin Mast Cells Contribute to Sporothrix schenckii Infection [PDF]

, 2020
Background: Sporothrix schenckii (S. schenckii), a dimorphic fungus, causes sporotrichosis. Mast cells (MCs) have been described to be involved in skin fungal infections. The role of MCs in cutaneous sporotrichosis remains largely unknown. Objectives:
Frischbutter, Stefan, Geng, Peng, Jiao, Qingqing, Li, Ruoyu, Luo, Ying, Maurer, Marcus, Scheffel, Jörg, Wang, Yuhan, Zhao, Zuotao   +8 more
core   +1 more source

Regulation of Toll-like receptor 1 and -2 in neonatal mice brains after hypoxia-ischemia

Journal of Neuroinflammation, 2011
Background Hypoxic-ischemic (HI) brain injury remains a major problem in newborns, resulting in increased risk of neurological disorders. Neonatal HI triggers a broad inflammatory reaction in the brain, including activation of the innate immune system ...
Naylor Andrew S, Smith Peter LP, Stridh Linnea, Wang Xiaoyang, Mallard Carina   +4 more
doaj   +1 more source

TLR-2 and IL-17A in Chitin-Induced Macrophage Activation and Acute Inflammation [PDF]

The Journal of Immunology, 2008
Abstract Chitin is a ubiquitous polysaccharide in fungi, insects, and parasites. To test the hypothesis that chitin is an important immune modulator, we characterized the ability of chitin fragments to regulate murine macrophage cytokine production in vitro and induce acute inflammation in vivo. In this study, we show that chitin is a
Carla A, Da Silva, Dominik, Hartl, Wei, Liu, Chun G, Lee, Jack A, Elias   +4 more
openaire   +2 more sources

TLR 2/1 interaction of pectin depends on its chemical structure and conformation

Carbohydrate Polymers, 2023
Citrus pectins have demonstrated health benefits through direct interaction with Toll-like receptor 2. Methyl-ester distribution patterns over the homogalacturonan were found to contribute to such immunomodulatory activity, therefore molecular interactions with TLR2 were studied.
Jermendi, Éva, Fernández-Lainez, Cynthia, Beukema, Martin, López-Velázquez, Gabriel, van den Berg, Marco A., de Vos, Paul, Schols, Henk A.   +6 more
openaire   +4 more sources

HMGB1-Induced Cross Talk between PTEN and miRs 221/222 in Thyroid Cancer [PDF]

, 2015
High mobility group box 1 (HMGB1) is an ubiquitous protein that plays different roles in the nucleus, cytoplasm and extra-cellular space. It is an important DAMP molecule that allows communication between damaged or tumor cells and the immune system ...
ANTONACI, Alfredo, FAGGIONI, Alberto, Fico, F., MARDENTE, Stefania, MARI, EMANUELA, MASSIMI, ISABELLA, PULCINELLI, FABIO MARIA, ZICARI, Alessandra   +7 more
core   +4 more sources

Association between toll-like receptor genes polymorphism (TLR2, TLR4, and TLR6) and SARS-CoV-2 infection in the West Siberian region of Russia

Инфекция и иммунитет
The presence of preceding cardiovascular disease (CVD) is an important risk factor for the severe clinical course of COVID-19. In addition, COVID-19 is often aggravated by cardiovascular complications.
Alla V. Shevchenko, V. F. Prokofiev, V. I. Konenkov, A. A. Karaseva, A. D. Afanaseva, I. I. Logvinenko   +5 more
doaj   +1 more source

Toll-like receptor (TLR) 2 and 4 mutations in periodontal disease

Clinical and Experimental Immunology, 2004
SUMMARY Toll-like receptors (TLR) are signal molecules essential for the cellular response to bacterial cell wall components. Different functional effective polymorphisms for the TLR 4 gene (Asp299Gly; Thr399Ile) and for the TLR 2 gene (Arg677Trp, Arg753Gln) have recently been described that are associated with impaired ...
M, Folwaczny, J, Glas, H-P, Török, O, Limbersky, C, Folwaczny   +4 more
openaire   +3 more sources

Peculiarities of Tlr-2 (Arg753gln) and Tlr-4 (Asp299gly) Polymorphism Prevalence in Patients with Acute Brucelleis and Cardiovascular System Diseases [PDF]

, 2019
Currently, there are single data on the relationship between TLR-2 polymorphisms (Arg753Gln) and TLR-4 (Asp299Gly) polymorphisms and susceptibility to brucellosis.
Huseynov, E. M. (Elchin)
core  

Gaps between zeros of the derivative of the Riemann \xi-function [PDF]

, 2009
Assuming the Riemann hypothesis, we investigate the distribution of gaps between the zeros of \xi'(s). We prove that a positive proportion of gaps are less than 0.796 times the average spacing and, in the other direction, a positive proportion of gaps ...
Bui, H. M.
core   +2 more sources

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source