Results 121 to 130 of about 183,650 (307)

CD14 Plays a Critical Role in Pain and Inflammation Across Multiple Models of Post‐traumatic Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine osteoarthritis (OA) models that vary in severity of pathology and rate of progression to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt, Sanique M. South, Natalie S. Adamczyk, Vu Nguyen, Shingo Ishihara, Cheng Zhou, Kate L. Sharp, Sung Y. Kim, Anna E. Rapp, Baofeng Hu, Lance A. Murphy, Li‐Yin Hung, De'Broski Herbert, Joshua F. Baker, Robert L. Mauck, Timothy M. Griffin, Anne‐Marie Malfait, Rachel E. Miller, Carla R. Scanzello   +18 more
wiley   +1 more source

ASSOCIATION OF POLYMORPHIC MARKERS IN GENES OF INNATE IMMUNITY IN PATIENTS WITH PERIODONTITIS AND INFLAMMATORY DISEASES OF UPPER RESPIRATORY TRACT

Журнал микробиологии, эпидемиологии и иммунобиологии, 2016
Aim. Search of association of polymorphisms in DEFВ1, IL-10, TNF-a and TLR2 genes with development of chronic generalized periodontitis in representatives of Ural region (Caucasian race). Materials and methods. 142 patients, that were split into 3 groups,
N. G. Sarkisyan, L. V. Gankovskaya, I. A. Tuzankina, O. A. Svitich, G. I. Ron, V. N. Shershnev, O. N. Kolyadina, M. A. Dolgikh   +7 more
doaj  

Effect of agar and biofilm culture of Francisella tularensis on TLR2 and TLR4 genes expression in blood and spleen cells of experimental animals

Acta Biomedica Scientifica
Biofilm as a form of existence of many bacteria that allows them to survive in unfavorable environmental conditions. Such pathogens include some strains of tularemia pathogen.
V. I. Dubrovina, A. B. Pyatidesyatnikova, O. V. Yuryeva, K. M. Korytov, T. P. Starovoitova, A. V. Mazepa, K. V. Naumova, S. V. Balakhonov   +7 more
doaj   +1 more source

The peculiarities of pneumonias course in case of grippe for patients with TLR-2, TLR-3, TLR-4 genes polymorphism

, 2014
Цель - проанализировать течение гриппа, осложненного пневмонией, у пациентов с полиморфизмом генов TLR-2 Arg753Gln, TLR-3 Leu412Phe, TLR-4 Asp299Gly. В исследование были включены 36 пациентов (25 женщин и 11 мужчин) преимущественно молодого и среднего ...
Dubynska, G., Pryimenko, N., Прийменко, Наталія Олегівна, Дубинська, Галина Михайлівна, Прийменко, Наталья Олеговна, Дубинская, Галина Михайловна   +5 more
core  

TLR-3 is regulated in vivo.

, 2014
TLR-3 mRNA organ expressions (A). Activation of TLR-3 during ischemia and reperfusion (B) Western Blot and RT-PCR analyses of the TLR-3 signaling pathway: IRF3, TRIF and IFN-β1 (C ...
Nicholas Obermüller (505231), Daniela Penzkofer (505233), Bertram Scheller (318724), Johannes Holfeld (318725), Joelle Schlammes (552517), Patrick Paulus (318716), Katrin Rupprecht (505232), Christin Reissig (452008), Patrick Baer (552516), Anja Urbschat (318726), Stefanie Dimmeler (134234), Kai Zacharowski (77285)   +11 more
core   +1 more source

Kidney Hematopoietic Stem and Progenitor Cells Contribute to Myeloid Development and Pathology in Lupus Nephritis

Arthritis &Rheumatology, EarlyView.
Objective The hematopoietic system maintains homeostasis by balancing myeloid and lymphoid cell production in the bone marrow (BM). In response to increased hematopoietic demand, extramedullary hematopoiesis (EMH) may occur in nonlymphoid organs. We investigated the role of EMH and kidney‐resident hematopoietic stem and progenitor cells (HSPCs) in ...
Hansol Yi, Seyoung Jung, Jeong Ho Joo, Young‐Eun Kim, Heounjeong Go, Yong‐Gil Kim, Chang‐Keun Lee, Bin Yoo, Jeong Seok Lee, Seokchan Hong   +9 more
wiley   +1 more source

The role of TLR-2, TLR-3, TLR-4 genes polymorphism in susceptibility formation to the inflammatory diseases of the respiratory tracts

, 2013
Метою дослідження було простежити зв'язок поліморфізму Arg753Gln гену TLR-2, Leu412Phe гену TLR-3, Asp299Gly гену TLR-4 зі схильністю до запальних захворювань дихальних шляхів і розвитком ускладнених форм гострих респіраторних вірусних інфекцій.
Pryimenko, N., Прийменко, Наталія Олегівна, Прийменко, Наталья Олеговна   +2 more
core   +1 more source

Persistent Interleukin‐18 Fuels Expansion of CD38+HLA‐DR+CD8+ T Cells in Still Disease and Macrophage Activation Syndrome

Arthritis &Rheumatology, EarlyView.
Objective Still disease (SD) is an autoinflammatory disorder characterized by remarkably high interleukin‐18 (IL‐18) levels. Increasing evidence suggests that adaptive immunity also contributes to its pathogenesis, particularly in refractory courses. Macrophage activation syndrome (MAS), one of SD's most severe complications, is associated with further
Greta Rogani, Remco G. A. Erkens, Alejandra Bodelón, Tim R. Mocking, Marein T. M. Putmans, Freya M. C. H. Huijsmans, Lyanne J. P. M. Sijbers, Aafke M. De Ligt, Maurice J. H. Van Haaren, Rianne C. Scholman, Noël M. M. Dautzenberg, Joyce I. Meesters‐Ensing, Martina Rossano, Laura Porretti, Stefan Nierkens, Francesca S. Minoia, Sebastiaan J. Vastert, Jorg van Loosdregt   +17 more
wiley   +1 more source

Features of toll-like receptor genes (TLR-2, TLR-3, TLR-4 and TLR-6) polymorphism in open-angle glaucoma patients

Вавиловский журнал генетики и селекции
Modern research shows that innate immunity plays an important role in the pathogenesis of primary open-angle glaucoma (POAG). An increase in the content of toll-like receptors (TLR) in the glaucomatous retina of the human eye was revealed.
A. V. Shevchenko, V. F. Prokofiev, V. I. Konenkov, V. V. Chernykh, A. N. Trunov   +4 more
doaj   +1 more source

Expression und Funktion der Toll-Like Rezeptoren TLR-4 und TLR-9 an Zelllinien des Harnblasenkarzinoms

, 2015
Das Harnblasenkarzinom ist eine der häufigsten malignen Tumorerkrankungen weltweit. 75%-85% der Patienten werden noch in nicht-muskelinvasiven Stadien diagnostiziert.
Olbert, P. (PD Dr.), Kesch, Claudia Verena   +1 more
core   +1 more source