Results 131 to 140 of about 183,650 (307)

Treatment‐Driven Peripheral Blood Transcriptomic Remodeling and Baseline Predictors of ESSDAI and STAR Response to B Cell Therapy in Sjögren's Disease

Arthritis &Rheumatology, EarlyView.
Graphical Abstract Objective This study aimed to characterize whole blood transcriptomic profiles in adults with active Sjögren's disease (SjD) treated with anti‐CD20 or B lymphocyte stimulator/BAFF inhibition, identify markers of clinical response, and define inflammatory pathways linked to nonresponse. Methods Whole blood RNA sequencing was performed
Aimen Ibrahim, Junjie Peng, Eileen Tian, Lucia Martin‐Gutierrez, John Casement, Kyle Thompson, Wan‐Fai Ng, André van Maurik, Elizabeth C. Jury, Coziana Ciurtin   +9 more
wiley   +1 more source

Association of Toll-like receptor polymorphism and gene expression level with the risk of developing chronic obstructive pulmonary disease (COPD) and its severity

Бюллетень сибирской медицины
Aim. Determine the influence of genetic factors of innate immunity on the risk of development and severity of COPD. Materials and methods. The study included 103 patients diagnosed with chronic obstructive pulmonary disease and 47 conditionally healthy ...
S. A. Salamaikina, V. I. Korchagin, K. O. Mironov, M. A. Karnaushkina   +3 more
doaj   +1 more source

Hyperresponsiveness of Corticoid-Resistant Th17/Tc-17 Cells to TLR-2 and TLR-4 Ligands is a Feature of Multiple Sclerosis Patients at Higher Risk of Therapy Failure [PDF]

Joana Hygino,1,* Marisa C Sales,2,* Priscila M Sacramento,1 Taissa M Kasahara,3 Júlio César Costa da Silva,3 Rafaela Bilhão,3 Regis M Andrade,4 Cláudia Cristina Ferreira Vasconcelos,1 Cleonice AM Bento1,3– 5 1Post-Graduate Program in Neurology ...
da Silva JCC, Bento CA, Sales MC, Kasahara TM, Bilhão R, Vasconcelos CCF, Hygino J, Andrade RM, Sacramento PM   +8 more
core  

TLR-2 and TLR-9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation

, 2011
Anthracycline antibiotics are inducers of an immunogenic form of apoptosis that has immunostimulatory properties because of the release of damage-associated molecular patterns.
Bogaert, Pieter, Woznicki, Jerzy, Bachert, Claus, Takahashi, Nozomi, O Krysko, L Heyndrickx, Magez, Stefan, J Woznicki, N Takahashi, Cauwels, Anje, S Magez, C Bachert, Krysko, Olga, Magez, S, P Bogaert, Kaczmarek, Agnieszka, A Cauwels, Vandenabeele, Peter, P Vandenabeele, Heyndrickx, Liesbeth, D V Krysko, A Kaczmarek, Krysko, Dmitri   +22 more
core   +1 more source

Lost and found in translation: the value of the human imiquimod model

British Journal of Clinical Pharmacology, EarlyView.
Topical imiquimod (IMQ), a Toll‐like receptor (TLR) 7 agonist, induces transient cutaneous inflammation and is widely used in preclinical research as a ‘psoriasis‐like’ mouse model. However, accumulating evidence indicates substantial divergence between IMQ‐driven biology and human plaque psoriasis pathogenesis.
Anouk C. Meijs, Juliette A. van den Noort, Salma Assil, Naomi B. Klarenbeek, Matthijs Moerland, Tessa Niemeyer‐van der Kolk, Robert Rissmann   +6 more
wiley   +1 more source

Induced TLR expression in Muller glia challenged with TLR ligands.

, 2013
MIO-M1 cells were left untreated (C) or stimulated with indicated TLR ligands Pam2Cys (10 µg/ml), Poly(IC) (10 µg/ml), LPS (10 µg/ml), Flagellin (250 ng/ml), Poly(dT) (10 µM/ml), and ODN (10 µg/ml) for 4 h.
Nazeem Shamsuddin (335669), Ashok Kumar (43100)   +1 more
core   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Comparison of TLR-2, TLR-4, and antimicrobial peptide levels in different lesions of acne vulgaris

, 2016
Kilic, Murat/0000-0002-1377-2021Context: Recent studies have shown that tolls like receptors (TLRs) and antimicrobial peptides (hBD-1, cathelicidin) play an important role in the pathogenesis of acne vulgaris (AV).Objective: To evaluate and report the ...
Oguztuzun, Serpil, Zemheri, Ebru, Akdeniz, Necmettin, Karadag, Ayse Serap, Kilic, Murat, Ozkanli, Seyma, Ozlu, Emin   +6 more
core   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Short-term thermal stratification and partial overturning events in a warm polymictic reservoir: effects on distribution of phytoplankton community

Brazilian Journal of Biology
In lentic freshwater ecosystems, patterns of thermal stratification play a considerable part in determining the population dynamics of phytoplankton.
RM. Santos, AA. Saggio, TLR. Silva, NF. Negreiros, O. Rocha   +4 more
doaj   +1 more source