Results 311 to 320 of about 175,490 (344)

Exploring the mechanism of action of astragaloside in the treatment of osteoarthritis based on network pharmacology. [PDF]

Biomed Eng Online
Song D, Li J, Sun Y, Li B, Lin X, Xu W, Wang Y, Wang D, Zhou G, Liu Y.   +9 more
europepmc   +1 more source

Albiflorin improves diabetic retinopathy by mitigating oxidative stress and inflammation via the TLR-4/NF-kB signaling pathway. [PDF]

Toxicol Res (Camb)
Xie L, Wang Y, Gong Y.
europepmc   +1 more source

Role of Toll-Like Receptors in Myeloid Neoplasms: Focuses on the Molecular Mechanisms and Clinical Impact on Myelodysplastic Syndromes, Acute Myeloid Leukemia, and Chronic Myeloid Leukemia. [PDF]

APMIS
Cavalcante CBA, Chaves AC, de Oliveira VS, de Araújo MAS, Cunha E Silva TM, Goes JVC, de Oliveira RTG, Pinheiro RF, Ribeiro-Junior HL.   +8 more
europepmc   +1 more source

Novel Hybrid Peptide DEFB126 (1-39)-TP5 Inhibits LPS-Induced Inflammatory Responses and Oxidative Stress by Neutralizing LPS and Blocking the TLR4/MD2-NFκB Signaling Axis. [PDF]

Antioxidants (Basel)
Tang Y, Zhao X, Ding Z, Wang J, Zhang J, Zhou Y, Ahmat M, Wang H, Zhu Y, Ahmad B, Abbas Z, Si D, Zhang R, Wei X.   +13 more
europepmc   +1 more source

Harnessing Distinct Tissue-Resident Immune Niches via S100A9/TLR4 Improves Ketone, Lipid, and Glucose Metabolism.

Endocrinology
Lucibello G, Ursino G, Teixeira PDS, Zahoran S, Fanuele F, Kallikourdis M, Visentin F, Veyrat-Durebex C, Widmer A, Wu Y, Cremonesi M, Wollheim CB, Castets P, Ramadori G, Coppari R.   +14 more
europepmc   +1 more source

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Involvement of ILR4α and TLR4 in miscarriages

Journal of Reproductive Immunology, 2019
The purpose of this study was to analyze the involvement of signaling via Interleukin-4-Receptor α (IL4Rα) and Toll like receptor (TLR) 4 at the fetomaternal interface in the process of early pregnancy.Placenta specimens of 46 patients in early pregnancy were analyzed (normal pregnancy (n = 15), spontaneous (n = 15) and habitual abortion (n = 16 ...
Theresa Maria Kolben, Elisabeth Rogatsch, Anna Hester, Christina Kuhn, Elisa Schmoeckel, Bastian Czogalla, Sven Mahner, Udo Jeschke, Thomas Kolben   +8 more
openaire   +3 more sources

TLR4 agonists as immunomodulatory agents

Journal of Endotoxin Research, 2006
Monophosphoryl lipid A (MPL®) is a potent vaccine adjuvant derived from Salmonella minnesota that was recently licensed in Europe as a component of an improved vaccine for hepatitis B (Fendrix®). MPL, like lipopolysaccharide from which it is derived, signals via the TLR4/MD-2 complex.
Peter Probst, Patrick McGowan, Mark R. Alderson, Jory R. Baldridge   +3 more
openaire   +3 more sources

TLR4 stresses the liver: Figure 1

Gut, 2012
Most types of chronic liver disease are characterised by hepatocellular necrosis, inflammation and tissue remodelling, ultimately resulting in progressive fibrosis and cirrhosis in a significant number of cases. Evidence from mouse and human studies implicates Toll-like receptors (TLRs) as central mediators of the inflammatory response and a crucial ...
Christian Trautwein, H Sahin, Hermann E. Wasmuth   +2 more
openaire   +3 more sources

Inflamed by TLR4 internalization [PDF]

Science, 2020
Immunology The pattern recognition receptor Toll-like receptor 4 (TLR4) stimulates the production of proinflammatory cytokines when activated on the cell surface, but endocytosed TLR4 signals through different effectors to drive the production of an antiviral cytokine called interferon-β. Metwally et al.
openaire   +1 more source