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Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4
Cancer Cell, 2012 Increased translocation of intestinal bacteria is a hallmark of chronic liver disease and contributes to hepatic inflammation and fibrosis. Here we tested the hypothesis that the intestinal microbiota and Toll-like receptors (TLRs) promote hepatocellular
Jean-Philippe Pradère +2 more
exaly +2 more sources
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Science, 2013
Cytoplasmic lipopolysaccharide from Gram-negative bacteria can activate the innate immune system directly.
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Cytoplasmic lipopolysaccharide from Gram-negative bacteria can activate the innate immune system directly.
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TLR4 polymorphisms and disease susceptibility
Inflammation Research, 2012Toll-like receptors (TLRs) play a central role in the regulation of the host immune system. Each TLR recognizes specific pathogen-associated molecular patterns (PAMPs). TLR4 is one of the well characterized pathogen recognition receptors (PRRs) that recognizes the lipopolysaccharide (LPS) of Gram-negative bacteria, some conserved structures from fungal
Mamoona, Noreen +7 more
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Biochemical and Biophysical Research Communications - BBRC, 2019
Loss of myocytes caused by cell death plays a key role during heart failure (HF). Activated autophagy and increased ferroptosis have been observed in HF and proved to promote its progression. However, the underlying mechanisms remain unclear.
Xiaoqing Chen +3 more
semanticscholar +1 more source
Loss of myocytes caused by cell death plays a key role during heart failure (HF). Activated autophagy and increased ferroptosis have been observed in HF and proved to promote its progression. However, the underlying mechanisms remain unclear.
Xiaoqing Chen +3 more
semanticscholar +1 more source
Trends in Microbiology, 2002
The recognition of microbial pathogens based on their molecular patterns is essential for host defense. Recently, Toll-like receptors have been shown not only to recognize viruses as well as bacteria and fungi, but also to trigger an efficient immune response.
Susan R Ross, John C Rassa
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The recognition of microbial pathogens based on their molecular patterns is essential for host defense. Recently, Toll-like receptors have been shown not only to recognize viruses as well as bacteria and fungi, but also to trigger an efficient immune response.
Susan R Ross, John C Rassa
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2009
The term acute bronchiolitis is used to describe the clinical syndrome that consists of respiratory distress and wheezing from a viral lower respiratory tract infection in children until the age of two years. RSV is the most common pathogen and it affects nearly 100% of children in the first two years of life.
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The term acute bronchiolitis is used to describe the clinical syndrome that consists of respiratory distress and wheezing from a viral lower respiratory tract infection in children until the age of two years. RSV is the most common pathogen and it affects nearly 100% of children in the first two years of life.
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TLR4 agonists as immunomodulatory agents
Journal of Endotoxin Research, 2006Monophosphoryl lipid A (MPL®) is a potent vaccine adjuvant derived from Salmonella minnesota that was recently licensed in Europe as a component of an improved vaccine for hepatitis B (Fendrix®). MPL, like lipopolysaccharide from which it is derived, signals via the TLR4/MD-2 complex.
Mark R, Alderson +3 more
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2020
Intracellular part of TLR4 signaling starts on the inner side of the cytoplasm and consists of two branches, namely, TLR4/TRIF/IRF3 and TLR4/MyD88/NF-κB. Through complex interactions including phosphorylation and ubiquitination, they lead to the activation of various transcription factors and are intrinsically regulated.
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Intracellular part of TLR4 signaling starts on the inner side of the cytoplasm and consists of two branches, namely, TLR4/TRIF/IRF3 and TLR4/MyD88/NF-κB. Through complex interactions including phosphorylation and ubiquitination, they lead to the activation of various transcription factors and are intrinsically regulated.
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2017
1196C/T ???????? TLR4 ?????????? ?????????? ?????????????? ?????????????????????? ???????????????????? (????) ???? ?????????????????? ?? ?????????????? ????????????????. ?? ???????????????????? ?????????????? ?????????????????????????? ?????????????????? ?? ?????????????? ?????????? TLR2 ?? TLR4 ??????????????????????, ?????? ?????????????????? ????????
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1196C/T ???????? TLR4 ?????????? ?????????? ?????????????? ?????????????????????? ???????????????????? (????) ???? ?????????????????? ?? ?????????????? ????????????????. ?? ???????????????????? ?????????????? ?????????????????????????? ?????????????????? ?? ?????????????? ?????????? TLR2 ?? TLR4 ??????????????????????, ?????? ?????????????????? ????????
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Inflamed by TLR4 internalization
Science, 2020Immunology The pattern recognition receptor Toll-like receptor 4 (TLR4) stimulates the production of proinflammatory cytokines when activated on the cell surface, but endocytosed TLR4 signals through different effectors to drive the production of an antiviral cytokine called interferon-β. Metwally et al.
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