Results 291 to 300 of about 272,563 (343)

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

Nature, 2009
Ho Min Kim, Jie-Oh Lee, Hayyoung Lee
exaly   +2 more sources

Toll-like receptor 4 (TLR4) inhibitors: Current research and prospective.

European journal of medicinal chemistry, 2022
Toll-like receptor 4 (TLR4), a member of the Toll-like receptor (TLR) family, is involved in innate immunity and mediates inflammatory responses by recognizing lipopolysaccharide (LPS) or bacterial endotoxins.
Yongsheng Zhang, Xinjie Liang, X. Bao, W. Xiao, Guoliang Chen   +4 more
semanticscholar   +1 more source

Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood

Nature Medicine, 2007
Zahra Goodarzi, Margaret M Kelly, Kamala D Patel   +2 more
exaly   +2 more sources

Effect of gut microbiota on LPS-induced acute lung injury by regulating the TLR4/NF-kB signaling pathway.

International Immunopharmacology, 2020
Acute lung injury (ALI) is a common acute respiratory disease treated in the clinic. Intestinal microflora disorder affect lung diseases through the gut-lung axis.
Jia-feng Tang, Lingqi Xu, Yiwen Zeng, Fang Gong   +3 more
semanticscholar   +1 more source

Reconstruction of LPS Transfer Cascade Reveals Structural Determinants within LBP, CD14, and TLR4-MD2 for Efficient LPS Recognition and Transfer

Immunity, 2017
Je-Kyung Ryu, Sang-Hyun Rah, Hi Eun Jung
exaly   +2 more sources

Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

Cell Metabolism, 2018
Gerard Pernes, Paul Timpson, Seth L Masters   +2 more
exaly   +2 more sources

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

Nature Genetics, 2000
Joseph Zabner, Joel N Kline, David A Schwartz   +2 more
exaly   +2 more sources

TLR4 biased small molecule modulators

Pharmacology & Therapeutics, 2021
Biased pharmacological modulators provide potential therapeutic benefits, including greater pharmacodynamic specificity, increased efficiency and reduced adverse effects. Therefore, the identification of such modulators as drug candidates is highly desirable.
Lin, C., Wang, H., Zhang, M., Mustafa, S., Wang, Y., Li, H., Yin, H., Hutchinson, M.R., Wang, X.   +8 more
openaire   +3 more sources

Circ-TLR4 promotes cardiac hypertrophy through recruiting FUS to stabilize TLR4 mRNA

Journal of Interventional Cardiac Electrophysiology, 2022
Cardiac hypertrophy is an adaptive and compensatory mechanism preserving cardiac output during detrimental stimuli. Circular RNAs (circRNAs) have been illustrated to exert important implications in the pathogenesis of multiple cardiovascular diseases (CVD) including demonstrated cardiac hypertrophy.
Chao Li, Jingwen Wang, Jun Feng, Jiangrong Zhou, Linlin Hou, Yu Gao, Ziping Cheng   +6 more
openaire   +2 more sources

Beta-amyloid activates NLRP3 inflammasome via TLR4 in mouse microglia.

Neuroscience Letters, 2020
Beta-amyloid(Aβ)-induced inflammation plays a critical role in the pathogenesis of Alzheimer's disease (AD). Nod-like receptor nucleotide-binding domain leucine rich repeat containing protein 3 (NLRP3) inflammasome is involved in the Aβ-induced ...
Yang Liu, Yue Dai, Qing Li, Chen Chen, Hao Chen, Yuan-Jian Song, F. Hua, Zuohui Zhang   +7 more
semanticscholar   +1 more source