Results 41 to 50 of about 4,902 (167)
The Prognostic Value and Mechanisms of TMEM16A in Human Cancer
Frontiers in Molecular Biosciences, 2021 As a calcium ion-dependent chloride channel transmembrane protein 16A (TMEM16A) locates on the cell membrane. Numerous research results have shown that TMEM16A is abnormally expressed in many cancers.
Wenjian Chen +11 more
doaj +1 more source
Die Bedeutung des vaskulären TMEM16A in der Entstehung der pulmonalen Hypertonie [PDF]
, 2021 Die pulmonale Hypertonie (PH) ist keine ätiopathogenetische Entität, sondern eine heterogene Gruppe verschiedener Erkrankungen. Die jeweils zugrundeliegende Pathophysiologie ist durch unterschiedliche beteiligte Komponenten komplex.
Tessmer, Philipp
core
CLCA1 Regulates Airway Mucus Production and Ion Secretion Through TMEM16A [PDF]
, 2021 TMEM16A, a Ca2+-activated chloride channel (CaCC), and its regulator, CLCA1, are associated with inflammatory airway disease and goblet cell metaplasia.
Raquel Centeio +7 more
core +1 more source
Frontiers in Pharmacology, 2021 Background: Effective anticancer therapy can be achieved by identifying novel tumor-specific drug targets and screening of new drugs. Recently, TMEM16A has been identified to be overexpressed in lung adenocarcinoma, and inhibitors of TMEM16A showed ...
Shuai Guo +9 more
doaj +1 more source
TMEM16A Inhibition Preserves Blood–Brain Barrier Integrity After Ischemic Stroke
Frontiers in Cellular Neuroscience, 2019 The inflammatory response plays a pivotal role in Blood–Brain Barrier (BBB) destruction following ischemic brain injury. Enhanced leukocyte adhesion to vascular endothelial cells is an essential event in the inflammatory process.
Pin-yi Liu +17 more
doaj +1 more source
Regulation of TMEM16A by CK2 and Its Role in Cellular Proliferation
Cells, 2020 Casein kinase 2 (CK2) is a highly ubiquitous and conserved serine/threonine kinase that forms a tetramer consisting of a catalytic subunit (CK2α) and a regulatory subunit (CK2β). Despite being ubiquitous, CK2 is commonly found at higher expression levels
Madalena C. Pinto +6 more
doaj +1 more source
Frontiers in Physiology, 2023 Cl− channels such as the Ca2+ activated Cl− channel TMEM16A and the Cl− permeable phospholipid scramblase TMEM16F may affect the intracellular Cl− concentration ([Cl−]i), which could act as an intracellular signal.
Raquel Centeio +3 more
doaj +1 more source
Advanced Science, 2020 Nonalcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease, and the mechanisms underpinning its pathogenesis have not been completely established.
Jia‐Wei Guo +15 more
doaj +1 more source
Expression of TMEM16A in various nasal glands of TMEM16A-/- and TMEM16A+/+ littermate mice.
, 2015 Expression of TMEM16A and aquaporin 5 in the Bowman’s gland (BG), nasal septal gland (NSG) and lateral nasal gland (LNG) of TMEM16A-/- and TMEM16A+/+ littermate mice.
Devendra Kumar Maurya (753367) +7 more
core +1 more source
Intestinal TMEM16A control luminal chloride secretion in a NHERF1 dependent manner
Biochemistry and Biophysics Reports, 2021 TMEM16A (Transmembrane protein 16A or Anoctamin1) is a calcium-activated chloride channel.(CaCC),that exerts critical roles in epithelial secretion. However, its localization, function, and regulation in intestinal chloride (Cl−) secretion remain obscure.
Tultul Saha +9 more
doaj +1 more source