Results 121 to 130 of about 6,139 (238)
The Journal of Physiology, Volume 604, Issue 15, Page 6348-6368, 1 August 2026.Abstract figure legend Physiological functions of PKD1, a large transmembrane polycystin protein, are unclear. Previous results obtained using germline non‐specific knockout mice suggested that PKD1 regulates arterial smooth muscle cell contractility.
Angélica K. Bernardelli +7 more
wiley +1 more source
Artificial Intelligence for Bone: Theory, Methods, and Applications
Advanced Intelligent Discovery, Volume 2, Issue 3, June 2026.Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan +3 more
wiley +1 more source
Cells, 2020 TMEM16A/anoctamin1 (ANO1), a calcium (Ca2+)-activated chloride (Cl−) channel, has many functions in various excitable cells and modulates excitability in both Ca2+- and voltage-gating modes.
Sun-Sook Paik +2 more
doaj +1 more source
Effects of DP on TMEM16A expression.
, 2015 TMEM16A protein expression were determined by western blotting after SW620 cells were treated with 5 μM of DP for 24, 48 or 72 h (above). Control SW620 cells were treated with DMSO for 24 h. β-actin was used as a loading control.
Junfeng Lv (836713) +11 more
core +1 more source
Bioengineered 3D hPSC‐Cholangiocyte Ducts With Physiological Signals for Biliary Disease Modeling
Advanced Healthcare Materials, Volume 15, Issue 20, 27 May 2026.Tian and colleagues generated a bioengineered bile duct from human pluripotent stem cell (hPSC)‐derived intrahepatic cholangiocytes within a high‐throughput, 384‐well platform to systematically examine the influence of biliary physiological signals including fluid flow, stromal cells and bile acids, and models intrahepatic biliary disease progression ...
Britney Tian +10 more
wiley +1 more source
Upregulation of TMEM16A Protein in Bronchial Epithelial Cells by Bacterial Pyocyanin.
PLoS ONE, 2015 Induction of mucus hypersecretion in the airway epithelium by Th2 cytokines is associated with the expression of TMEM16A, a Ca2+-activated Cl- channel. We asked whether exposure of airway epithelial cells to bacterial components, a condition that mimics ...
Emanuela Caci +13 more
doaj +1 more source
Endothelial Dysfunction Following Enhanced TMEM16A Activity in Human Pulmonary Arteries
Cells, 2020 Endothelial dysfunction is one of the hallmarks of different vascular diseases, including pulmonary arterial hypertension (PAH). Ion channelome changes have long been connected to vascular remodeling in PAH, yet only recently has the focus shifted ...
Davor Skofic Maurer +12 more
doaj +1 more source
Intermolecular Interactions in the TMEM16A Dimer Controlling Channel Activity
, 2018 TMEM16A e TMEM16B sono proteine di membrana con funzione di canali del cloruro attivati da calcio. Attraverso la generazione di canali chimerici, e in particolare, sostituendo la regione carbossi-terminale di TMEM16A con la regione equivalente di ...
SCUDIERI, PAOLO
core +1 more source
Mechanisms underlying gastric antral slow waves – a human perspective
The Journal of Physiology, EarlyView.
Dirk F. van Helden
wiley +1 more source
Trans-ε-viniferin as an inhibitor of TMEM16A preventing intestinal smooth muscle contraction
, 2023 TMEM16A regulator is an important tool to study the physiological functions and pathogenesis related to TMEM16A. In the present study, trans-ε-viniferin (TV) was identified as a TMEM16A inhibitor with inhibitory activity against TMEM16A mediated Cl ...
Ling-Ling Jin (16882508) +4 more
core +1 more source