Results 11 to 20 of about 3,827 (168)

Development of the Olfactory Epithelium and Nasal Glands in TMEM16A-/- and TMEM16A+/+ Mice. [PDF]

PLoS ONE, 2015
TMEM16A/ANO1 is a calcium-activated chloride channel expressed in several types of epithelia and involved in various physiological processes, including proliferation and development.
Devendra Kumar Maurya, Tiago Henriques, Monica Marini, Nicoletta Pedemonte, Luis J V Galietta, Jason R Rock, Brian D Harfe, Anna Menini   +7 more
doaj   +8 more sources

Ca2+-activated Cl− channel TMEM16A inhibition by cholesterol promotes angiogenesis in endothelial cells

Journal of Advanced Research, 2021
Introduction: Ca2+-activated Cl− channel TMEM16A is expressed in endothelial cells, and contributes to many diseases such as hypertension, blood-brain barrier dysfunction, and pulmonary hypertension.
Qinghuan Xiao
exaly   +3 more sources

The diverse roles of TMEM16A Ca2+-activated Cl− channels in inflammation

Journal of Advanced Research, 2021
Background: Transmembrane protein 16A (TMEM16A) Ca2+-activated Cl− channels have diverse physiological functions, such as epithelial secretion of Cl− and fluid and sensation of pain.
Qinghuan Xiao
exaly   +3 more sources

Ca²⁺-Activated Cl^- Channels: Do Bestrophins and TMEM16A Interact? [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim Ca2+‐activated Cl– conductances are present in many cell types and are important for regulating membrane potential as well as other cellular functions. TMEM16A is widely accepted as the principal molecular basis for Ca2+‐activated Cl– conductances, but also members of the bestrophin family may be important for some Ca2+‐activated Cl ...
Aalkjær C, Dam VS, Nilsson H, Boedtkjer DB, Matchkov V.   +4 more
europepmc   +2 more sources

TMEM16A Ca2+-activated Cl− channel inhibition ameliorates acute pancreatitis via the IP3R/Ca2+/NFκB/IL-6 signaling pathway

Journal of Advanced Research, 2020
TMEM16A Ca2+-activated Cl− channels are expressed in pancreatic acinar cells and participate in inflammation-associated diseases. Whether TMEM16A contributes to the pathogenesis of acute pancreatitis (AP) remains unknown.
Qinghuan Xiao
exaly   +3 more sources

The Prognostic Value and Mechanisms of TMEM16A in Human Cancer [PDF]

Frontiers in Molecular Biosciences, 2021
As a calcium ion-dependent chloride channel transmembrane protein 16A (TMEM16A) locates on the cell membrane. Numerous research results have shown that TMEM16A is abnormally expressed in many cancers.
Wenjian Chen, Wenjian Chen, Meng Gu, Meng Gu, Chaobing Gao, Bangjie Chen, Junfa Yang, Junfa Yang, Xiaoli Xie, Xinyi Wang, Jun Sun, Jinian Wang   +11 more
doaj   +3 more sources

Intracellular TMEM16A is necessary for myogenesis of skeletal muscle

iScience, 2022
Summary: Transmembrane protein 16A (TMEM16A) localizes at plasma membrane and controls chloride influx in various type of cells. We here showed an intracellular localization pattern of TMEM16A molecules.
Wen Yuan, Cong-Cong Cui, Jing Li, Yan-Hua Xu, Chun-E Fan, Yu-Chen Chen, Hong-Wei Fan, Bing-Xue Hu, Mei-Yun Shi, Zhi-Yuan Sun, Pei Wang, Teng-Xiang Ma, Zhao Zhang, Min-Sheng Zhu, Hua-Qun Chen   +14 more
doaj   +3 more sources

HIF-Regulated Pannexin-1 Channel Drives Luminal ATP Accumulation in Kidney Cysts. [PDF]

FASEB J
Autosomal dominant polycystic kidney disease causes progressive cyst enlargement in the kidneys, leading to hypoxia and induction of HIF‐1α. Our study identifies HIF‐1α‐dependent transcriptional upregulation of Pannexin1 (PANX1) in the apical membrane of cyst epithelial cells, promoting ATP release into the cyst lumen.
Skoczynski K, Scholz JK, Ursu R, Schödel J, Grampp S, Naas S, Lauer V, Schiffer M, Büttner-Herold M, Buchholz B, Kraus A.   +10 more
europepmc   +2 more sources

The CLCA1/TMEM16A/Cl– current axis associates with H2S deficiency in diabetic kidney injury [PDF]

JCI Insight
The role played by anionic channels in diabetic kidney disease (DKD) is not known. Chloride channel accessory 1 (CLCA1) facilitates the activity of TMEM16A (Anoctamin-1), a Ca2+-dependent Cl– channel. We examined if CLCA1/TMEM16A had a role in DKD.
Hak Joo Lee, Yuyang Sun, Falguni Das, Wenjun Ju, Viji Nair, Christopher G. Kevil, Shankara Varadarajan, Guanshi Zhang, Goutam Ghosh Choudhury, Brij B. Singh, Matthias Kretzler, Robert G. Nelson, Kumar Sharma, Balakuntalam S. Kasinath   +13 more
doaj   +2 more sources

Co-targeting TMEM16A with a novel monoclonal antibody and EGFR with Cetuximab inhibits the growth and metastasis of esophageal squamous cell carcinoma [PDF]

Journal of Translational Medicine
The chloride channel transmembrane protein 16A (TMEM16A) possesses a calcium-activated property linked to tumor-promoting malignant phenotype and electrophysiological stability.
Yutian Zheng, Lin Meng, Like Qu, Chuanke Zhao, Lixin Wang, Jiayi Ma, Caiyun Liu, Chengchao Shou   +7 more
doaj   +2 more sources