Results 41 to 50 of about 4,623 (196)
Fractionation of a herbal antidiarrheal medicine reveals eugenol as an inhibitor of Ca2+-Activated Cl- channel TMEM16A. [PDF]
PLoS ONE, 2012 The Ca(2+)-activated Cl(-) channel TMEM16A is involved in epithelial fluid secretion, smooth muscle contraction and neurosensory signaling. We identified a Thai herbal antidiarrheal formulation that inhibited TMEM16A Cl(-) conductance. C18-reversed-phase
Zhen Yao +5 more
doaj +1 more source
Arctigenin Attenuates Vascular Inflammation Induced by High Salt through TMEM16A/ESM1/VCAM-1 Pathway
Biomedicines, 2022 Salt-sensitive hypertension is closely related to inflammation, but the mechanism is barely known. Transmembrane member 16A (TMEM16A) is the Ca2+-activated chloride channel in epithelial cells, smooth muscle cells, and sensory neurons.
Mengying Zeng +5 more
doaj +1 more source
Expression of TMEM16A and SLC4A4 in Human Pancreatic Islets [PDF]
Cellular Physiology and Biochemistry, 2012 Stimulation of insulin release by D-glucose is accompanied by Cl(-) and HCO(3)(-) efflux from pancreatic islet cells. The efflux of these anions may involve volume-regulated anion channels, including possibly TMEM16A, and the Na(+)-HCO(3)(-)-cotransporter SLC4A4.
Hanzu, Felicia A +7 more
openaire +3 more sources
Acta Pharmaceutica Sinica B, 2021 Vascular smooth muscle cell (VSMC) migration plays a critical role in the pathogenesis of many cardiovascular diseases. We recently showed that TMEM16A is involved in hypertension-induced cerebrovascular remodeling.
Huaqing Zheng +10 more
doaj +1 more source
CLCA1 Regulates Airway Mucus Production and Ion Secretion Through TMEM16A [PDF]
, 2021 TMEM16A, a Ca2+-activated chloride channel (CaCC), and its regulator, CLCA1, are associated with inflammatory airway disease and goblet cell metaplasia.
Raquel Centeio +7 more
core +1 more source
ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC) [PDF]
Pflügers Archiv - European Journal of Physiology, 2014 Pancreatic ductal adenocarcinoma (PDAC) has one of the worst survival rates of all cancers. ANO1 (TMEM16A) is a recently identified Ca(2+)-activated Cl(-) channel (CaCC) that is upregulated in several tumors. Although ANO1 was subject to extensive studies in the recent years, its pathophysiological function has only been poorly understood.
Sauter, Daniel Rafael Peter +4 more
openaire +4 more sources
Frontiers in Physiology, 2022 Background: Cardiac hypertrophy (CH) occurs with an increase in myocardium mass as an adaptive compensation to increased stress. Prolonged CH causes decompensated heart failure (HF).
Yaofang Zhang +4 more
doaj +1 more source
TMEM16A chloride channel does not drive mucus production
Life Science Alliance, 2019 Despite being essential for airway hydration, TMEM16A is not required for mucus (MUC5AC) production. Cell proliferation is the main driver for TMEM16A up-regulation during inflammation.
Filipa B Simões +7 more
doaj +1 more source
Increased complexity of Tmem16a/Anoctamin 1 transcript alternative splicing [PDF]
, 2011 Background TMEM16A (Anoctamin 1; ANO1) is an eight transmembrane protein that functions as a calcium-activated chloride channel. TMEM16A in human exhibits alternatively spliced exons (6b, 13 and 15), which confer important roles in the ...
Fiona C Britton +2 more
core +1 more source
Gating the pore of the calcium-activated chloride channel TMEM16A [PDF]
Nature Communications, 2021 AbstractThe binding of cytoplasmic Ca2+ to the anion-selective channel TMEM16A triggers a conformational change around its binding site that is coupled to the release of a gate at the constricted neck of an hourglass-shaped pore. By combining mutagenesis, electrophysiology, and cryo-electron microscopy, we identified three hydrophobic residues at the ...
Lam, Andy K M +3 more
openaire +4 more sources