Results 141 to 150 of about 3,827 (168)

Recent progress in structural studies on TMEM16A channel

Computational and Structural Biotechnology Journal, 2020
The calcium-activated chloride channel, also known as TMEM16A, shows both calcium and membrane potential dependent activation. The channel is expressed broadly and contributes to a variety of physiological processes, and it is expected to be a target for the treatment of diseases such as hypertension, pain, cystic fibrosis and lung cancer.
Yafei Chen, Hailong An, Sai Shi
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Paving the way for designing drugs targeting TMEM16A

Trends in Pharmacological Sciences, 2021
The calcium-activated chloride channel TMEM16A is involved in several physiological processes and is an important pharmacological target. Dinsdale and colleagues recently unveiled several residues in the outer pore region that constitute a critical site for the design of drugs that modulate TMEM16A channels.
Simone Pifferi, Anna Menini
openaire   +2 more sources

Dysregulation of TMEM16A impairs oviductal transport of embryos

American Journal of Physiology-Cell Physiology, 2023
The ion channel protein TMEM16A is expressed in the epithelium and smooth muscle of the human fallopian tube and is upregulated in patients with tubal pregnancy. TMEM16A is involved in regulating the smooth muscle contraction and the cilia beating. Dysregulated TMEM16A may result in embryo retention in the oviduct and delayed early embryo development.
Nannan Ning, Dan Luo, Wei Xia, Guangjing Mou, Jiangli Zhao, Jian Zhang, Cheng Li, Hongchun Wang, Jingxin Li   +8 more
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Downregulation of Ca2+-Activated Cl− Channel TMEM16A by the Inhibition of Histone Deacetylase in TMEM16A-Expressing Cancer Cells

The Journal of Pharmacology and Experimental Therapeutics, 2014
The Ca(2+)-activated Cl(-) channel transmembrane proteins with unknown function 16 A (TMEM16A; also known as anoctamin 1 or discovered on gastrointestinal stromal tumor 1) plays an important role in facilitating the cell growth and metastasis of TMEM16A-expressing cancer cells.
Sayo, Matsuba, Satomi, Niwa, Katsuhiko, Muraki, Saki, Kanatsuka, Yurika, Nakazono, Noriyuki, Hatano, Masanori, Fujii, Peng, Zhan, Takayoshi, Suzuki, Susumu, Ohya   +9 more
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TMEM16A (ANO1) as a therapeutic target in cystic fibrosis

Current Opinion in Pharmacology, 2022
Cystic fibrosis (CF) is a multi-organ genetic disease caused by loss of function of CFTR, a cAMP-regulated chloride channel expressed in epithelial cells. In airway epithelia, CFTR-dependent chloride secretion is required to humidify mucosal surface and to allow efficient mucociliary clearance.
openaire   +3 more sources

Recent advances in TMEM16A: Structure, function, and disease

Journal of Cellular Physiology, 2018
AbstractTMEM16A (also known as anoctamin 1, ANO1) is the molecular basis of the calcium‐activated chloride channels, with ten transmembrane segments. Recently, atomic structures of the transmembrane domains of mouse TMEM16A (mTMEM16A) were determined by single‐particle electron cryomicroscopy.
Qiushuang Ji, Shuai Guo, Xuzhao Wang, Chunli Pang, Yong Zhan, Yafei Chen, Hailong An   +6 more
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Relationship between TMEM16A/anoctamin 1 and LRRC8A

Pflügers Archiv - European Journal of Physiology, 2016
TMEM16A/anoctamin 1/ANO1 and VRAC/LRRC8 are independent chloride channels activated either by increase in intracellular Ca(2+) or cell swelling, respectively. In previous studies, we observed overlapping properties for both types of channels. (i) TMEM16A/ANO1 and LRRC8 are inhibited by identical compounds, (ii) the volume-regulated anion channel VRAC ...
Roberta, Benedetto, Lalida, Sirianant, Ines, Pankonien, Podchanart, Wanitchakool, Jiraporn, Ousingsawat, Ines, Cabrita, Rainer, Schreiber, Margarida, Amaral, Karl, Kunzelmann   +8 more
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Regulation of ANO1/TMEM16A anion permeability

Pancreatology, 2013
Background/aim: Bicarbonate (HCO3 ) is an important ingredient in many biological fluids including saliva. However, calcium activated chlo ride channels (CaCCs) in salivary gland acinar cells are known to be poorly permeable to HCO3 in most cases. Methods: To elucidate the possibility of ANO1 as a HCO3 channel, anion currents were measured in HEK 293T ...
Jinsei Jung, Joo Hyun Nam, Hyun Woo Park, Uhtaek Oh, Joo-heon Yoon, Min Goo Lee   +5 more
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TMEM16A channels and their role in taste

The Journal of Physiology, 2021
Xi Yue Zhang, Matthew J. Novello
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TMEM16A/B Associated CaCC: Structural and Functional Insights

Protein & Peptide Letters, 2013
Calcium-activated chloride channels (CaCCs) play fundamental roles in numerous physiological processes. Transmembrane proteins 16A and 16B (TMEM16A/B) were identified to be the best molecular identities of CaCCs to date. This makes molecular investigation of CaCCs become possible. This review discusses the latest findings of TMEM16A/B associated CaCCs,
Chunli, Pang, Hongbo, Yuan, Shuxi, Ren, Yafei, Chen, Hailong, An, Yong, Zhan   +5 more
openaire   +2 more sources