Results 81 to 90 of about 3,802 (167)
Secreted CLCA1 modulates TMEM16A to activate Ca2+-dependent chloride currents in human cells
eLife, 2015 Calcium-activated chloride channel regulator 1 (CLCA1) activates calcium-dependent chloride currents; neither the target, nor mechanism, is known. We demonstrate that secreted CLCA1 activates calcium-dependent chloride currents in HEK293T cells in a ...
Monica Sala-Rabanal +3 more
doaj +1 more source
Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement
Cell Reports, 2020 Summary: The secreted protein calcium-activated chloride channel regulator 1 (CLCA1) utilizes a von Willebrand factor type A (VWA) domain to bind to and potentiate the calcium-activated chloride channel TMEM16A.
Kayla N. Berry, Tom J. Brett
doaj +1 more source
Bioengineered 3D hPSC‐Cholangiocyte Ducts With Physiological Signals for Biliary Disease Modeling
Advanced Healthcare Materials, Volume 15, Issue 20, 27 May 2026.Tian and colleagues generated a bioengineered bile duct from human pluripotent stem cell (hPSC)‐derived intrahepatic cholangiocytes within a high‐throughput, 384‐well platform to systematically examine the influence of biliary physiological signals including fluid flow, stromal cells and bile acids, and models intrahepatic biliary disease progression ...
Britney Tian +10 more
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.TMEM92 protects DDX3X from degradation by the E3 ligase TTC3, promoting TNBC cell proliferation and tumour growth. Depleting TMEM92 not only suppresses tumour growth but also sensitises cells to cisplatin, suggesting that targeting this axis is a potential therapeutic strategy.
Hao Shen +12 more
wiley +1 more source
Endothelial Dysfunction Following Enhanced TMEM16A Activity in Human Pulmonary Arteries
Cells, 2020 Endothelial dysfunction is one of the hallmarks of different vascular diseases, including pulmonary arterial hypertension (PAH). Ion channelome changes have long been connected to vascular remodeling in PAH, yet only recently has the focus shifted ...
Davor Skofic Maurer +12 more
doaj +1 more source
Pathogenesis of Age‐Related Hearing Loss and Therapeutic Strategies
Sensory Neuroscience, Volume 2, Issue 1, March 2026.ABSTRACT Age‐related hearing loss (ARHL) is a degenerative disorder of the auditory system, characterized by bilateral symmetrical sensorineural hearing loss that occurs with aging. As a highly prevalent age‐related condition worldwide, ARHL significantly impairs both the quality of life and mental health of the elderly.
Yu Xiao +6 more
wiley +1 more source
9‐phenanthrol inhibits TMEM16A channels
The FASEB Journal, 2013 Intravascular pressure stimulates several smooth muscle cell TRP channels, including TRPM4, leading to membrane depolarization and vasoconstriction (the myogenic response). Previous studies using 9‐phenanthrol (9‐phen), a TRPM4 channel inhibitor, suggest that TRPM4 is essential for pressure‐induced depolarization and constriction ...
Sarah Burris +2 more
openaire +1 more source
Upregulation of TMEM16A Protein in Bronchial Epithelial Cells by Bacterial Pyocyanin.
PLoS ONE, 2015 Induction of mucus hypersecretion in the airway epithelium by Th2 cytokines is associated with the expression of TMEM16A, a Ca2+-activated Cl- channel. We asked whether exposure of airway epithelial cells to bacterial components, a condition that mimics ...
Emanuela Caci +13 more
doaj +1 more source
Mechanisms underlying gastric antral slow waves – a human perspective
The Journal of Physiology, EarlyView.
Dirk F. van Helden
wiley +1 more source
Mechanism of persistent hyperalgesia in neuropathic pain caused by chronic constriction injury
Neural Regeneration Research, 2019 Transmembrane member 16A (TMEM16A) is involved in many physiological functions, such as epithelial secretion, sensory conduction, nociception, control of neuronal excitability, and regulation of smooth muscle contraction, and may be important in ...
Qin-Yi Chen +5 more
doaj +1 more source