Results 101 to 110 of about 3,924 (173)

Regulation of TMEM16A altrenatice splincing

, 2012
TMEM16A/Anoctamin1 is a novel calcium-­‐activated chloride channel involved in neuronal and cardiac excitation, vascular tone, pain perception and olfactory and sensory signal transduction and GI tract motility. It is also associated to diverse type of cancer including breast cancer malignancy. Alternative splicing (AS) of exons 6b, 13 and 15 generates
openaire   +1 more source

The role and regulation of TMEM16A in the vascular system

, 2019
TMEM16A is a Ca2+-activated Cl- channel (CaCC) encoded by the TMEM16A gene, expressed in vascular smooth muscle cells (VSMCs). TMEM16A has a proposed role in depolarising the membrane potential (Vm) in response to activation of the Gq-protein coupled receptor (Gq-PCR) signalling cascade.
openaire   +1 more source

Loss of Vascular TMEM16A Impairs Cerebral Autoregulation and Exacerbates Ischemia-reperfusion Injury. [PDF]

Transl Stroke Res
Andersen AC, Larsen ID, Melnikova EV, Gernemann M, Skryabin BV, Pedersen TM, Beck HC, Guldbrandsen HØ, Gutierrez E, Aalkjaer C, Postnov DD, Matchkov VV, Hansen LMB.   +12 more
europepmc   +1 more source

Epithelial Chloride and Bicarbonate Transport in Intestinal Barrier Failure: A Molecular Target-Validation Assessment of CFTR and SLC26A3/DRA in Inflammatory Bowel Disease. [PDF]

Int J Mol Sci
Seo Y.
europepmc   +1 more source

TRPV4-driven ATP release activates CFTR through ADORA2B and P2RY2 receptors in the airway epithelium. [PDF]

iScience
Genovese M, De Santis M, Giordano A, Marotta P, Galietta LJV.   +4 more
europepmc   +1 more source

ANO1 (TMEM16A) Genetic Variants, Promoter Methylation, and Chloride Dysregulation in Pulmonary Hypertension. [PDF]

J Cardiovasc Dev Dis
Yaman İ, Korkmaz H, Akağaç AE, Kaymaz T, Önder R, Önalan EE.   +5 more
europepmc   +1 more source

A pericyte chloride clamp mechanism governs capillary control of cerebral blood flow. [PDF]

Proc Natl Acad Sci U S A
Xiang L, Hariharan A, Isaacs D, Weir N, Longden TA.   +4 more
europepmc   +1 more source

Myometrial mechanotransduction and the timing of parturition: ion-channel pathways linking uterine stretch, calcium signaling, and inflammation. [PDF]

Front Physiol
Han X, Wu T, Hu X.
europepmc   +1 more source

Natural Products Targeting Airway Inflammation and Mucus Hypersecretion: Molecular Mechanisms and Therapeutic Potential for Respiratory Health. [PDF]

Nutrients
Lee SG, Lee JH, Kang H.
europepmc   +1 more source

Combining Gene Therapy with Current Modulator Treatments for Cystic Fibrosis: A Promising Area of Research. [PDF]

Pharmaceutics
Buin X, Ghanem R, Pankonien I, Becq F, Amaral M, Montier T.   +5 more
europepmc   +1 more source