Results 131 to 140 of about 3,827 (168)

Tamsulosin ameliorates bone loss by inhibiting the release of Cl^- through wedging into an allosteric site of TMEM16A. [PDF]

Proc Natl Acad Sci U S A
Li S, Sun W, Li S, Zhu L, Guo S, He J, Li Y, Tian C, Zhao Z, Yu T, Li J, Zhang Y, Hai Y, Wang J, Zheng Y, Wang R, Hu X, Ling S, Li H, Li Y.   +19 more
europepmc   +1 more source

Characterization of TMEM16F-Specific Affibodies and Their Cellular Effects. [PDF]

Membranes (Basel)
Kim E, Bang J, Kim S, Lee BC.
europepmc   +1 more source

Beyond the mutations: spatiotemporal regulation of CFTR by cAMP and calcium signaling in epithelial physiology and cystic fibrosis. [PDF]

Cell Mol Biol Lett
Varga A, Kiss A, Crul T, Madácsy T, Pallagi P, Maléth J.   +5 more
europepmc   +1 more source

The roles and functions of TMEM protein family members in cancers, cardiovascular and kidney diseases (Review). [PDF]

Biomed Rep
Xu H, Yang S, Liu P, Zhang Y, Zhang T, Lan J, Jiang H, Wu D, Li J, Bai X.   +9 more
europepmc   +1 more source

Spontaneous Calcium Signalling in the Developing Mammalian Cochlea. [PDF]

J Assoc Res Otolaryngol
Ceriani F, Marcotti W.
europepmc   +1 more source

Distinct modulation of calcium-activated chloride channel TMEM16A by drug-binding sites. [PDF]

Proc Natl Acad Sci U S A
Roh JW, Gee HY, Wainger B, Kim WK, Lee W, Nam JH.   +5 more
europepmc   +1 more source

TMEM16A Activation Inhibits Autophagy in Dorsal Root Ganglion Cells, Which is Associated with the p38 MAPK/mTOR Pathway. [PDF]

Cell Mol Neurobiol
Yang S, Shang H, Zhang Y, Qiu J, Guo Z, Ma Y, Lan Y, Cui S, Tong H, Li G.   +9 more
europepmc   +1 more source

The multifaceted role of TMEM16A in cancer

Cell Calcium, 2019
The calcium-activated chloride channel TMEM16A is intimately linked to cancers. Over decades, TMEM16A over-expression and contribution to prognosis have been widely studied for multiple cancers strengthening the idea that TMEM16A could be a valuable biomarker and a promising therapeutic target.
David Crottès, Lily Jan
exaly   +7 more sources

Pharmacological characterization of TMEM16A currents [PDF]

Channels, 2014
Recent studies have shown that transmembrane protein 16 A (TMEM16A) is a subunit of calcium-activated chloride channels (CACCs). Pharmacological agents have been used to probe the functional role of CACCs, however their effect on TMEM16A currents has not been systematically investigated.
Gérard sergeant, Keith Thornbury, Mark Hollywood   +2 more
exaly   +3 more sources

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Emerging Modulators of TMEM16A and Their Therapeutic Potential

Journal of Membrane Biology, 2021
Calcium-activated chloride channels (CaCCs) are widespread chloride channels which rely on calcium activation to perform their functions. In 2008, TMEM16A (also known as anoctamin1, ANO1) was identified as the molecular basis of the CaCCs, which provided the possibility to study the physiological function of CaCCs.
Xuzhao Wang, Yafei Chen, Hailong An
exaly   +3 more sources