Results 121 to 130 of about 43,824 (207)
Analysis of Fascin-1 in Relation to Gleason Risk Classification and Nuclear ETS-Related Gene Status of Human Prostate Carcinomas:An Immunohistochemical Study of Clinically Annotated Tumours From the Wales Cancer Bank [PDF]
, 2017 Although prostate-specific antigen (PSA) testing can identify early-stage prostate cancers, additional biomarkers are needed for risk stratification. In one study, high levels of the actin-bundling protein, fascin-1, were correlated with lethal-phase ...
Adams, Jo +5 more
core +4 more sources
Increased ACE2 and TMPRSS2 expression in ulcerative colitis
Pathology - Research and PracticeUlcerative colitis (UC) is a cryptogenic inflammatory bowel disease, and there is an urgent need to elucidate its pathogenesis. ACE2 and TMPRSS2, the entry molecules of SARS-CoV-2, are reportedly associated with the disease; however, no consensus has been reached yet.
Yuichiro Hamamoto +7 more
openaire +3 more sources
Aromatase, testosterone, TMPRSS2: determinants of COVID-19 severity
Biology of Sex DifferencesAbstract Background Male sex has been identified as a risk factor for worse COVID-19 outcomes. This sex difference has been mostly attributed to the complex role of sex hormones. Cell surface entry of SARS-CoV-2 is mediated by the transmembrane protease serine 2 (TMPRSS2) which is under transcriptional regulation by ...
Eric C. Mohan +9 more
openaire +3 more sources
CRISPR-Cas9 genetic screens reveal regulation of TMPRSS2 by the Elongin BC-VHL complex
Scientific ReportsThe TMPRSS2 cell surface protease is used by a broad range of respiratory viruses to facilitate entry into target cells. Together with ACE2, TMPRSS2 represents a key factor for SARS-CoV-2 infection, as TMPRSS2 mediates cleavage of viral spike protein ...
Ildar Gabaev +11 more
doaj +1 more source
Influenza pseudotype production with TMPRSS2
, 2013 The human Transmembrane Protease Serine 2 is necessary for the produc5on of Group 2 influenza A virus pseudotypes. This poster was presented at the Spring meeting of the SGM, Manchester 2013.
openaire +1 more source
Human coronavirus HKU1 recognition of the TMPRSS2 host receptor
CellThe human coronavirus HKU1 spike (S) glycoprotein engages host cell surface sialoglycans and transmembrane protease serine 2 (TMPRSS2) to initiate infection. The molecular basis of HKU1 binding to TMPRSS2 and determinants of host receptor tropism remain elusive. We designed an active human TMPRSS2 construct enabling high-yield recombinant production in
Matthew McCallum +11 more
openaire +5 more sources
TMPRSS2: Potential Biomarker for COVID‐19 Outcomes [PDF]
The Journal of Clinical Pharmacology, 2020 Strope, Jonathan D. +2 more
openaire +2 more sources
Frontiers in Genome EditingInfluenza A virus (IAV) infection is initiated by hemagglutinin (HA), a glycoprotein exposed on the virion’s lipid envelope that undergoes cleavage by host cell proteases to ensure membrane fusion, entry into the host cells, and completion of the viral ...
Giovana Ciacci Zanella +10 more
doaj +1 more source
Impact of the SPOP Mutant Subtype on the Interpretation of Clinical Parameters in Prostate Cancer. [PDF]
, 2018 Purpose: Molecular characterization of prostate cancer, including The Cancer Genome Atlas, has revealed distinct subtypes with underlying genomic alterations.
Alshalalfa, Mohammed +17 more
core +1 more source