Results 131 to 140 of about 31,965 (231)

TMPRSS2/ERG Fusions [PDF]

, 2008
Jianghua Wang, Yi Cai, Michael Ittmann
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Pigs lacking TMPRSS2 displayed fewer lung lesions and reduced inflammatory response when infected with influenza A virus

Frontiers in Genome Editing
Influenza A virus (IAV) infection is initiated by hemagglutinin (HA), a glycoprotein exposed on the virion’s lipid envelope that undergoes cleavage by host cell proteases to ensure membrane fusion, entry into the host cells, and completion of the viral ...
Giovana Ciacci Zanella, Giovana Ciacci Zanella, Celeste A. Snyder, Bailey L. Arruda, Kristin Whitworth, Kristin Whitworth, Erin Green, Ravikanth Reddy Poonooru, Bhanu P. Telugu, Bhanu P. Telugu, Amy L. Baker   +10 more
doaj   +1 more source

TMPRSS2: Potential Biomarker for COVID‐19 Outcomes [PDF]

The Journal of Clinical Pharmacology, 2020
Strope, Jonathan D., PharmD, Cindy H. Chau,, Figg, William D.   +2 more
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Expression of ACE2 and TMPRSS2 and the severity of COVID‑19

Biomedical Reports
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19), uses the angiotensin-converting enzyme 2 (ACE2) receptor and transmembrane serine protease 2 (TMPRSS2) to enter host cells. Variability in gene expression of these entry factors has been hypothesized to influence susceptibility ...
Sanches De Carvalho, Samantha, Blanco Capassi Santos, Anna Carolina, Shiroma Graziano, Marcos Yuji, Peres, Marina Cristina, Sousa Silva, Renan, Trufelli, Isabella Dudjak Rosa, Luciano Da Veiga, Glaucia, Fonseca, Fernando Luiz Affonso, Da Costa Aguiar Alves, Beatriz   +8 more
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TMPRSS2: A Key Host Factor in SARS-CoV-2 Infection and Potential Therapeutic Target

Medeniyet Medical Journal
The transmembrane serine protease 2 (TMPRSS2) gene plays a crucial role in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by priming the viral spike protein for membrane fusion and facilitating viral entry into host cells.
Haily Liduin KOYOU, Mohd Nazil SALLEH, Caroline Satu JELEMIE, Mohd Jaamia Qaadir BADRIN, Muhammad Evy PRASTIYANTO, Vasudevan RAMACHANDRAN   +5 more
doaj   +1 more source

TMPRSS2 wt Allele [PDF]

, 2020
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Human Transmembrane Serine Protease 2 (TMPRSS2) on Human Seminal Fluid Extracellular Vesicles Is Proteolytically Active

Journal of Extracellular Vesicles
Human transmembrane serine protease 2 (TMPRSS2) has garnered substantial interest due to its clinical significance in various pathologies, notably its pivotal role in viral entry into host cells.
Emile Verhulst, Michelle De Bruyn, Pascale Berckmans, Yani Sim, Koen Augustyns, Isabel Pintelon, Maya Berg, Pieter Van Wielendaele, Anne‐Marie Lambeir, Yann G.‐J. Sterckx, Inge Nelissen, Ingrid De Meester   +11 more
doaj   +1 more source

Blocking serine protease (TMPRSS2) by Bromhexine; looking at potential treatment to prevent COVID-19 infection

Marshall Journal of Medicine, 2020
Ramin Tolouian, Audrey Tolouian , Mohammadreza Ardalan   +2 more
doaj   +1 more source

TMPRSS2/ETV1 Fusion Gene [PDF]

, 2020
openaire   +1 more source

TMPRSS2 regulates ACE2 trafficking and shedding

Abstract Angiotensin-converting enzyme 2 (ACE2) functions as the receptor for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus utilizes the cellular endocytic machinery for entry by binding to defined residues on ACE2 with its spike protein (S protein), whose activation requires a priming process by another ...
Yue Qiu, Elena Popova, Oliver Popp, Philipp Mertins, Bernadette Nickl, Fatimunnisa Qadri, Michael Bader   +6 more
openaire   +1 more source