Results 121 to 130 of about 31,828 (224)

Systematic analysis of genomic alterations in prostate cancer

, 2011
PhDProstate cancer is the most common male cancer in Western countries. The genetic mechanism underlying its initiation and progression is still unclear.
Mao, Xueying
core  

Low concentrations of siRNA TMPRSS2-ERG III and IV impair TMPRSS2-ERG oncogene and oncoprotein levels but not cell viability.

, 2015
VCaP cells were transfected for 72h from 2.5 nM to 50 nM with siRNA TMPRSS2-ERG III, siRNA TMPRSS2-ERG IV or siRNA Control. a. RT-qPCR analysis: relative TMPRSS2-ERG fusion variants III and IV mRNA levels were analysed and compared to non-treated cells ...
Quentin Rousseau (733381), Liliane Massaad-Massade (347698), Didier Desmaële (2520874), Patrick Couvreur (554924), Giorgia Urbinati (554921), Hubert Chapuis (554922), Hafiz Muhammad Ali (554920)   +6 more
core   +1 more source

CRISPR-Cas9 genetic screens reveal regulation of TMPRSS2 by the Elongin BC-VHL complex

Scientific Reports
The TMPRSS2 cell surface protease is used by a broad range of respiratory viruses to facilitate entry into target cells. Together with ACE2, TMPRSS2 represents a key factor for SARS-CoV-2 infection, as TMPRSS2 mediates cleavage of viral spike protein ...
Ildar Gabaev, Alexandra Rowland, Emilija Jovanovic, Christian M. Gawden-Bone, Thomas W. M. Crozier, Ana Teixeira-Silva, Edward J. D. Greenwood, Pehuén Pereyra Gerber, Niek Wit, James A. Nathan, Nicholas J. Matheson, Paul J. Lehner   +11 more
doaj   +1 more source

Organoids: From Bench to Bedside Applications

MedComm, Volume 7, Issue 6, June 2026.
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li, Rui Cao, Maochen Li, Zichao Tian, Huahao Fan, Bixia Hong, Xiaojuan Liu   +6 more
wiley   +1 more source

Hyperaldosteronism in Mice Lacking the Distal Polybasic Tract of the γ‐Subunit of the Epithelial Sodium Channel During Sodium Restriction

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aims The epithelial sodium channel ENaC consists of the subunits α, β, and γ and is activated at an individual channel level by proteolytic processing. Murine γENaC contains a distal polybasic tract 186RKRK mediating proteolytic ENaC activation by serine proteases in vitro.
Daniel Essigke, M. Zaher Kalo, Matthias Wörn, Xia‐Qing Li, Bernhard N. Bohnert, Anja Schork, Andreas L. Birkenfeld, Thomas Ott, Ferruh Artunc   +8 more
wiley   +1 more source

Influenza pseudotype production with TMPRSS2

, 2013
The human Transmembrane Protease Serine 2 is necessary for the produc5on of Group 2 influenza A virus pseudotypes. This poster was presented at the Spring meeting of the SGM, Manchester 2013.
openaire   +1 more source

Homology Modeling and Docking Studies of TMPRSS2 with Experimentally Known Inhibitors Camostat Mesylate, Nafamostat and Bromhexine Hydrochloride to Control SARS-Coronavirus-2

, 2020
The rapid outbreak of SARS-Coronavirus 2 (SARS-CoV-2) caused a serious global public health threat. The spike ‘S’ protein of SARS-CoV-2 and ACE2 of the host cell are being targeted to design and discover new drugs to control Covid-19 disease.
Kailas, Sonawane, Maruti J., Dhanavade, Sagar S., Barale, Subodh A., Kamble, Naiem H., Nadaf, Shailesh R., Waghmare, Ali Abdulmawjood, Mohammed, Ambika S., Dound, Nitin M., Naik, Prayagraj M., Fandilolu, Asiya M., Makandar   +10 more
core   +1 more source

TMPRSS2-ERG fusion promotes prostate cancer metastases in bone.

, 2017
Bone metastasis is the major deleterious event in prostate cancer (PCa). TMPRSS2-ERG fusion is one of the most common chromosomic rearrangements in PCa. However, its implication in bone metastasis development is still unclear.
Marchand, Nathalie, Deplus, Rachel, Delliaux, Carine, Duterque-Coquillaud, Martine, De Launoit, Yvan, Leroy, Xavier, Vanpouille, Nathalie, Flourens, Anne   +7 more
core   +1 more source

Charakterisierung der hämagglutininspaltenden Transmembranserinproteasen Matriptase und TMPRSS2

, 2020
Influenza is one of the commonest infectious diseases affecting millions of people every year including 290,000 – 650,000 heavy casualties. Influenza viruses undergo constant genetic changes and every 10 – 50 years new influenza virus strains emerge that
Keils, Aline
core   +1 more source

Klonierung, Expression und enzymkinetische Charakterisierung der hämagglutininspaltenden Protease TMPRSS2

, 2014
TMPRSS2 ist eine Typ II transmembrane Serinprotease mit einer multidomänen Struktur, die das Oberflächenglykoprotein Hämagglutinin (HA) der Influenzaviren mit einer monobasischen Schnittstelle spaltet.
Steinmetzer, Torsten (Prof. Dr.), Meyer, Daniela   +1 more
core   +1 more source