Results 121 to 130 of about 31,965 (231)

Increased Prevalence of Rare Copy Number Variants in Australian Children With Fetal Alcohol Spectrum Disorder: Experience in a State‐Wide Diagnostic Service

Alcohol, Clinical and Experimental Research, Volume 50, Issue 8, August 2026.
Of 175 Australian children with fetal alcohol spectrum disorder (FASD), 90% had genetic testing, and of those, 24% had a rare copy number variant (CNV). Genetic testing supports the FASD diagnostic process and may reveal additional diagnoses or sources of genetic vulnerability to FASD.
Suzy Byrnes, Felicity Collins, Elizabeth Elliott   +2 more
wiley   +1 more source

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation, Volume 59, Issue 8, August 2026.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
wiley   +1 more source

Szelektív TMPRSS2 gátlószer in vitro farmakológiai jellemzése [PDF]

, 2015
A TMPRSS2 egy olyan membránhoz kötött szerin proteáz enzim, amely szerepet játszik az influenzavírusos megbetegedésekben és egyes daganatok esetén a metasztázis képződés folyamatában. Célunk egy szintetikus 3-amidinofenilalanin alapvázú szelektív TMPRSS2
Czimmermann, Ágnes Eszter
core  

Counteracting Influenza Virus Evolution Through the Full Spectrum of Broadly Protective Antibodies

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Despite the presence of licensed vaccines and therapeutics, influenza viruses remain a major public health concern, as they cause seasonal respiratory infections and pose a pandemic threat through the emergence of zoonotic strains. Although neutralizing antibodies elicited by seasonal vaccination constitute a primary defense against infection,
Yu Adachi, Yoshimasa Takahashi
wiley   +1 more source

A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon.

PLoS ONE, 2016
Fusion between TMPRSS2 and ERG, placing ERG under the control of the TMPRSS2 promoter, is the most frequent genetic alteration in prostate cancer, present in 40-50% of cases.
Dong Gao, Yu Zhan, Wei Di, Amanda R Moore, Jessica J Sher, Youxin Guan, Shangqian Wang, Zeda Zhang, Devan A Murphy, Charles L Sawyers, Ping Chi, Yu Chen   +11 more
doaj   +1 more source

Exosome‐Mediated Delivery of PROTACs for Targeted Protein Degradation in Cancer, Neurodegenerative, Infectious, and Inflammatory Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are heterobifunctional molecules that hijack the ubiquitin‐proteasome system to drive catalytic, sub‐stoichiometric degradation of disease‐associated proteins, offering a mechanistic advantage over occupancy‐driven inhibitors and access to ‘undruggable’ targets.
Sruti Bagchi Ghosh, Rumpa Banerjee, Hailah M. Almohaimeed, Amany I. Almars, Tahani Ahmad ALMatrafi, Fayez M. Saleh, Zuhair M. Mohammedsaleh, Kranti Kiran Reddy Ealla, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the SARS-coronavirus spike-protein [PDF]

, 2014
The type II transmembrane serine proteases TMPRSS2 and HAT can cleave and activate the spike protein (S) of the severe acute respiratory syndrome coronavirus (SARS-CoV) for membrane fusion.
Heurich, A., Liepold, T., Liepold, Thomas, Hofmann-Winkler, Heike, Hofmann-Winkler, H., Gierer, S., Heurich, Adeline, Gierer, Stefanie, Pöhlmann, S., Jahn, Olaf, Jahn, O., Pöhlmann, Stefan   +11 more
core   +1 more source

Alignment analysis of TMPRSS2 protein tertiary structure. [PDF]

Alignment analysis of TMPRSS2 protein tertiary structure.
Marzieh Eskandarzadeh (18388767), Ali Mohebbi (4433587), Hanieh Zangi (18388770), Marzie Fatehi (18388773)   +3 more
core   +1 more source

Difference in TMPRSS2 usage by Delta and Omicron variants of SARS-CoV-2: Implication for a sudden increase among children.

PLoS ONE
It has been postulated from a combination of evidence that a sudden increase in COVID-19 cases among pediatric patients after onset of the Omicron wave was attributed to a reduced requirement for TMPRSS2-mediated entry in pediatric airways with lower ...
Sosuke Kakee, Kyosuke Kanai, Akeno Tsuneki-Tokunaga, Keisuke Okuno, Noriyuki Namba, Katsuyuki Tomita, Hiroki Chikumi, Seiji Kageyama   +7 more
doaj   +1 more source

Molecular basis of TMPRSS2 recognition by Paeniclostridium sordellii hemorrhagic toxin [PDF]

Hemorrhagic toxin (TcsH) is a major virulence factor produced by Paeniclostridium sordellii, which is a non-negligible threat to women undergoing childbirth or abortions.
Yanyan Li, Liang Tao, Liuqing He, Xiechao Zhan, Ruoyu Zhou, Xiaofeng Zhang, Jiahao Zhang   +6 more
core   +1 more source