Results 111 to 120 of about 31,965 (231)

Spatial transcriptomics reveals clonal relationships between intraductal carcinoma and adjacent invasive prostate cancer

Histopathology, Volume 89, Issue 3, Page 429-441, September 2026.
Spatial transcriptomics of six prostate samples reveals a close clonal relationship between high‐grade Prostatic Intraepithelial Neoplasia (HGPIN), Intraductal carcinoma (IDC) and adjacent invasive glands. In three samples, adjacent invasive glands had more copy number variants than HGPIN and IDC. Adjacent invasive glands were also placed at the end of
Hridya Harikumar, Myrthe de Waard‐van Baardwijk, Marit de Haan, Gregory van Beek, Karishma Lila, Martin E van Royen, Thierry PP van den Bosch, Mathijs A Sanders, Eric Bindels, Andrew Stubbs, Geert JLH van Leenders   +10 more
wiley   +1 more source

Klonierung, Expression und enzymkinetische Charakterisierung der hämagglutininspaltenden Protease TMPRSS2 [PDF]

, 2014
TMPRSS2 ist eine Typ II transmembrane Serinprotease mit einer multidomänen Struktur, die das Oberflächenglykoprotein Hämagglutinin (HA) der Influenzaviren mit einer monobasischen Schnittstelle spaltet.
Steinmetzer, Torsten (Prof. Dr.), Meyer, Daniela   +1 more
core   +1 more source

In‐Vitro Evaluation of HIV/SARS‐CoV‐2 Co‐Infection Mediated Proteomic Changes in Astrocytes and Pericytes Reveals Altered Signaling Pathways Associated With Neurodegenerative Disorders

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT Coronavirus disease 2019 (COVID‐19) survivors frequently experience a wide range of symptoms known as post‐acute sequelae of SARS‐CoV‐2 (PASC) or long COVID. Importantly, complications arising from microvascular dysfunction, blood‐brain barrier (BBB) disruption, and chronic neuroinflammation have been implicated in driving PASC within the ...
Arpan Acharya, Michellie Thurman, Debapriya Sutar, Oluwatayo Israel Olasunkanmi, Johid R. Malik, Shetty Ravi Dyavar, Ákos Végvári, Siddappa N. Byrareddy   +7 more
wiley   +1 more source

Investigation of PDCD1 Gene Polymorphisms and Haplotypes in COVID‐19 Severity and Outcome in a Brazilian Population

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT COVID‐19 severity and survival are influenced by the host immune response to SARS‐CoV‐2. Programmed cell death 1 (PD‐1), a key immune checkpoint, regulates T‐cell activation and antiviral immune balance. Since genetic variability can modulate these responses, we investigated whether the PDCD1 polymorphisms rs11568821 C > T, rs2227982 G > A ...
Sarah Lott Moretto, Pedro Luis Candido de Souza Cassela, Guilherme Lerner Trigo, Marcell Alysson Batisti Lozovoy, Zuleica Naomi Tano, Andrea Name Colado Simão, Karen Brajão de Oliveira   +6 more
wiley   +1 more source

Early‐Onset Prostate Cancer: Epidemiology, Risk Factors, Biology, Clinical Features, Management, and Early Detection

MedComm, Volume 7, Issue 8, August 2026.
EOPC is a distinct clinicopathological entity separable from SOPC, differing fundamentally in genetic susceptibility, TMPRSS2:ERG fusion frequency, and survival outcomes. Although research remains nascent, this review provides the first comprehensive synthesis of current evidence, offering a critical foundation to guide future investigations into this ...
Xingyu Xiong, Weizhen Zhu, Weichao Huang, Shiyu Zhang, Qi Deng, Jie Yang, Hang Xu, Qiang Wei, Lu Yang   +8 more
wiley   +1 more source

Expression of TMPRSS2 isoforms 1 and 2. [PDF]

, 2015
(A) Sequence alignment of the N-termini of TMPRSS2 isoforms 1 and 2. Identical amino acids are marked with stars. Amino acids absent in isoform 2 are marked with ‘–‘. (B) Plasmids encoding TMPRSS2 isoform 1 and isoform 2, both equipped with an N-terminal
Anna-Sophie Moldenhauer (142435), Heike Hofmann-Winkler (797086), Stefan Pöhlmann (142445), Pawel Zmora (797085)   +3 more
core   +1 more source

Proteomic and Phosphoproteomic Characteristics of Multiple Brain Regions in Rhesus Macaques After SARS‐CoV‐2 Infection

MedComm, Volume 7, Issue 8, August 2026.
The study found that SARS‐CoV‐2 Omicron infection causes region‐specific inflammatory, immune, synaptic, and signaling disorders in the brain, and the predicted kinases and differentially expressed proteins may serve as potential targets for COVID‐19‐related drug discovery.
Qiaochu Wang, Yanan Zhou, Tao Ding, Yan Sun, Yehong Yang, Yue Wu, Jiangfeng Liu, Shuaiyao Lu, Juntao Yang   +8 more
wiley   +1 more source

Influenza pseudotype production with TMPRSS2

, 2013
The human Transmembrane Protease Serine 2 is necessary for the produc5on of Group 2 influenza A virus pseudotypes. This poster was presented at the Spring meeting of the SGM, Manchester 2013.
openaire   +1 more source

Serine Protease Inhibitory Activity of Kampo Medicines: One of the Mechanisms Against Cold Syndrome

Traditional &Kampo Medicine, Volume 13, Issue 2, August 2026.
Serine protease inhibitory activity is involved in the mechanism of Kampo medicines used for treating common cold symptoms Ryokankyomishingeninto exhibited serine protease inhibitory activity in vitro and in vivo. Ryokankyomishingeninto showed anti‐SARS‐CoV‐2 activity in VeroE6/TMPRSS2 cells. ABSTRACT Aim Serine proteases play a key role in coronavirus
Yukiko Matsuo, Reina Akaiwa, Miku Yanagioka, Mishizu Kikuchi, Yuuna Kawahara, Takuma Yoshida, Hidemasa Nakaminami, Niro Inaba, Yoshihiro Mimaki   +8 more
wiley   +1 more source

CRISPR-Cas9 genetic screens reveal regulation of TMPRSS2 by the Elongin BC-VHL complex

Scientific Reports
The TMPRSS2 cell surface protease is used by a broad range of respiratory viruses to facilitate entry into target cells. Together with ACE2, TMPRSS2 represents a key factor for SARS-CoV-2 infection, as TMPRSS2 mediates cleavage of viral spike protein ...
Ildar Gabaev, Alexandra Rowland, Emilija Jovanovic, Christian M. Gawden-Bone, Thomas W. M. Crozier, Ana Teixeira-Silva, Edward J. D. Greenwood, Pehuén Pereyra Gerber, Niek Wit, James A. Nathan, Nicholas J. Matheson, Paul J. Lehner   +11 more
doaj   +1 more source