Results 91 to 100 of about 31,828 (224)

Mutations in ace2 gene modulate cytokine levels and alter immune responses in Mycobacterium tuberculosis and SARS-CoV-2 co-infection: a Cameroonian cohort

Frontiers in Immunology
IntroductionSARS-CoV-2 and Mycobacterium tuberculosis (Mtb) share similarities in their modes of transmission, pathophysiological symptoms, and clinical manifestations.
Mary Ngongang Kameni, Mary Ngongang Kameni, Mary Ngongang Kameni, Eric Berenger Tchoupe, Eric Berenger Tchoupe, Severin Donald Kamdem, Severin Donald Kamdem, Nikhil Bhalla, Jean Paul Assam Assam, Arnaud Njuiget Tepa, Fuh Roger Neba, Ranjan Kumar Nanda, Anthony Afum-Adjei Awuah, Anthony Afum-Adjei Awuah, Anthony Afum-Adjei Awuah, John Humphrey Amuasi, John Humphrey Amuasi, John Humphrey Amuasi, Palmer Masumbe Netongo, Palmer Masumbe Netongo, Palmer Masumbe Netongo   +20 more
doaj   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Enzima TMPRSS2 [PDF]

Revista de Ciência Elementar, 2021
Maria Ramos, Pedro Fernandes, Filipa Santos   +2 more
openaire   +1 more source

TMPRSS2, a novel membrane-anchored mediator in cancer pain [PDF]

Pain, 2015
More than half of all cancer patients have significant pain during the course of their disease. The strategic localization of TMPRSS2, a membrane-bound serine protease, on the cancer cell surface may allow it to mediate signal transduction between the cancer cell and its extracellular environment.
David K, Lam, Dongmin, Dang, Andrea N, Flynn, Markus, Hardt, Brian L, Schmidt   +4 more
openaire   +2 more sources

Soluble ACE2 and TMPRSS2 Levels in the Serum of Asthmatic Patients

Journal of Korean Medical Science, 2022
Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine subtype 2 (TMPRSS2) are key proteins mediating viral entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although gene expressions of ACE2 and TMPRSS2 have been analyzed in various organs and diseases, their soluble forms have been less studied, particularly in ...
Ji-Hyang Lee, Chae Eun Lee, Youngsang Yoo, Eunyong Shin, Jin An, Seo Young Park, Woo-Jung Song, Hyouk-Soo Kwon, You Sook Cho, Hee-Bom Moon, Tae-Bum Kim   +10 more
openaire   +2 more sources

Establishment of stable Vero cell lines expressing TMPRSS2 and MSPL: A useful tool for propagating porcine epidemic diarrhea virus in the absence of exogenous trypsin

Virulence, 2020
Porcine epidemic diarrhea virus (PEDV) is the causative agent of porcine epidemic diarrhea, causing substantial economic losses to the swine industry worldwide.
Xiaona Wang, Xinyuan Qiao, Ling Sui, Haiyuan Zhao, Fengsai Li, Yan-Dong Tang, Wen Shi, Yuyao Guo, Yanping Jiang, Li Wang, Han Zhou, Lijie Tang, Yigang Xu, Yijing Li   +13 more
doaj   +1 more source

FAM107A loss facilitates TTK‐OPTN‐mediated mitophagy to drive docetaxel resistance in castration‐resistant prostate cancer

Interdisciplinary Medicine, EarlyView.
In the progression of docetaxel resistance, downregulation of FAM107A releases its transcriptional repression of TTK, leading to TTK upregulation. TTK enhances the interaction and phosphorylation of OPTN. This activates mitophagy in tumor cells, facilitates clearance of damaged mitochondria, reduces intracellular reactive oxygen species accumulation ...
Yishan Zhang, Fan Zou, Mingdong Wang, Chenyue Wu, Yingwei Xie, Yongjun Quan, Wei Yan, Yupeng Zheng, Lianhua Li, Yuexin Liu, Jian Yu, Hao Ping   +11 more
wiley   +1 more source

Prevalence and prognostic significance of TMPRSS2-ERG gene fusion in lymph node positive prostate cancers.

, 2014
BACKGROUND TMPRSS2-ERG gene fusion is the most frequent genetic alteration in prostate cancer. However, information about its distribution in lymph node positive prostate cancers and the prognostic significance in these advanced tumors is unknown ...
Seiler, Roland, Zlobec, Inti, Visakorpi, Tapio, Fleischmann, Achim, Rotzer, Diana, Genitsch Gratwohl, Vera, Saramäki, Outi R, Thalmann, George   +7 more
core   +1 more source

TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model. [PDF]

PLoS ONE, 2011
Prostate cancer is the most common non-dermatologic malignancy in men in the Western world. Recently, a frequent chromosomal aberration fusing androgen regulated TMPRSS2 promoter and the ERG gene (TMPRSS2/ERG) was discovered in prostate cancer.
Orit Leshem, Shalom Madar, Ira Kogan-Sakin, Iris Kamer, Ido Goldstein, Ran Brosh, Yehudit Cohen, Jasmine Jacob-Hirsch, Marcelo Ehrlich, Shmuel Ben-Sasson, Naomi Goldfinger, Ron Loewenthal, Ephraim Gazit, Varda Rotter, Raanan Berger   +14 more
doaj   +1 more source

ACE2 & TMPRSS2 Expressions in Head & Neck Tissues: A Systematic Review

, 2020
International audienceTo review the data regarding the expression of angiotensin converting enzyme-2 (ACE2) and transmembrane protease serine-2 (TMPRSS2) in head and neck tissue.
Barillari, Maria, R, Michel, Justin, Barillari, Maria R, Hsieh, Julien, Saussez, Sven, Hans, Stéphane, Gengler, Isabelle, Chiesa-Estomba, Carlos M, de Riu, Giacomo, Calvo-Henriquez, Christian, Radulesco, Thomas, Cammaroto, Giovanni, Vaira, Luigi, Lechien, Jerome R, Descamps, Géraldine, Chiesa-Estomba, Carlos Miguel, Lechien, Jérôme, Chiesa-Estomba, Carlos,, Sowerby, Leigh, Lechien, Jerome,, Barillari, Maria,, Lechien, Jerome, R, Chiesa-Estomba, Carlos, M, Barillari, Maria Rosaria   +23 more
core   +2 more sources