Results 71 to 80 of about 31,965 (231)

Ginsenosides, potential TMPRSS2 inhibitors, a trade-off between the therapeutic combination for anti-PD-1 immunotherapy and the treatment of COVID-19 infection of LUAD patients

Frontiers in Pharmacology, 2023
Background: Acting as a viral entry for coronavirus to invade human cells, TMPRSS2 has become a target for the prevention and treatment of COVID-19 infection.
Mei Meng, Rui Gao, Zixue Liu, Fengxiang Liu, Shiyu Du, Shiyu Du, Shiyu Du, Yizhi Song, Jian He   +8 more
doaj   +1 more source

The use of equine influenza pseudotypes for serological screening [PDF]

, 2012
Standard assays used for influenza serology present certain practical issues, such as inter-laboratory variability, complex protocols and the necessity for handling certain virus strains in high biological containment facilities.
Ferrara, Francesca, Böttcher-Friebertshäuser, Eva, Temperton, Nigel J., Scott, Simon D., Temperton, Nigel, Daly, Janet, Molesti, Eleonora, Scott, Simon   +7 more
core  

Pilot survey among patients taking bromhexine prophylactically against influenza

Journal of Family Medicine and Primary Care
Background: The successful use of bromhexine hydrochloride (BRH) for COVID-19 prevention led us to apply the same method for flu prevention. The goal of this study is to observe whether BRH could protect people against influenza.
Vanyo Mitev, Violeta S. Dimitrova, Iva Miteva, Rumen Tiholov, Krasimir Marinov, Ani Miteva, Aleksander I. Lilov, Radoslav Bilyukov, Zornitsa Mihaylova, Nikolay Ishkitiev, Konstantin Tachkov, Tsanko Mondeshki   +11 more
doaj   +1 more source

Comparative Transcriptome Analysis Reveals the Intensive Early Stage Responses of Host Cells to SARS-CoV-2 Infection

Frontiers in Microbiology, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a widespread outbreak of highly pathogenic coronavirus disease 2019 (COVID-19). It is therefore important and timely to characterize interactions between the virus and host cell at ...
Jiya Sun, Jiya Sun, Fei Ye, Aiping Wu, Aiping Wu, Ren Yang, Mei Pan, Mei Pan, Jie Sheng, Jie Sheng, Wenjie Zhu, Wenjie Zhu, Longfei Mao, Longfei Mao, Ming Wang, Zanxian Xia, Baoying Huang, Wenjie Tan, Taijiao Jiang, Taijiao Jiang   +19 more
doaj   +1 more source

Status of TMPRSS2–ERG fusion in prostate cancer patients from India: correlation with clinico-pathological details and TMPRSS2 Met160Val polymorphism [PDF]

, 2018
Background: Prostate cancer (PCa) shows considerable clinical heterogeneity that has been primarily attributed to variable molecular alterations. TMPRSS2–ERG fusion is one such molecular subtype that has been associated with predominantly poor prognosis.
Aparna Bhanushali, Vaishnavi Raman, Asawari Ambekar, Prajakta Kokate, Swarna Mandva, Pranesh Rao, Simi Bhatia, B.R. Das   +7 more
core   +1 more source

Prediction of the effects of variants and differential expression of key host genes ACE2, TMPRSS2, and FURIN in SARS-CoV-2 pathogenesis: An in silico approach [PDF]

, 2021
A new strain of the beta coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is solely responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic.
Hossain, MS, Rahaman, MM, Fariha, A, Roy, AS, Islam, MN, Alam, MR, Tonmoy, MIQ, Kar, K, Islam, MS   +8 more
core   +1 more source

SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cells

Emerging Microbes and Infections, 2022
The novel SARS-CoV-2 Omicron variant (B.1.1.529), first found in early November 2021, has sparked considerable global concern and it has >50 mutations, many of which are known to affect transmissibility or cause immune escape. In this study, we sought to
Hanjun Zhao, Lu Lu, Zheng Peng, Lin-Lei Chen, Xinjin Meng, Chuyuan Zhang, Jonathan Daniel Ip, Wan-Mui Chan, Allen Wing-Ho Chu, Kwok-Hung Chan, Dong-Yan Jin, Honglin Chen, Kwok-Yung Yuen, Kelvin Kai-Wang To   +13 more
doaj   +1 more source

Inhibition of Influenza A virus propagation by benzoselenoxanthenes stabilizing TMPRSS2 Gene G-quadruplex and hence down-regulating TMPRSS2 expression [PDF]

Scientific Reports, 2020
AbstractProteolytic cleavage of influenza A virus (IAV) hemagglutinin by host proteases is crucial for virus infectivity and spread. The transmembrane serine protease TMPRSS2 was previously identified as the essential protease that can cleave hemagglutinin of many subtypes of influenza virus and spike protein of coronavirus.
Shen, Li-Wen, Qian, Man-Qing, Yu, Kai, Narva, Suresh, Yu, Fei, Wu, Yan-Ling, Zhang, Wen   +6 more
openaire   +2 more sources

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Binding free energies calculation of TMPRSS2-L₃, TMPRSS2-L₆, and TMPRSS2-L₇. [PDF]

Binding free energies calculation of TMPRSS2-L3, TMPRSS2-L6, and TMPRSS2-L7.
Marzieh Eskandarzadeh (18388767), Ali Mohebbi (4433587), Hanieh Zangi (18388770), Marzie Fatehi (18388773)   +3 more
core   +1 more source