Results 71 to 80 of about 33,857 (224)

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

Soluble ACE2 and TMPRSS2 Levels in the Serum of Asthmatic Patients

Journal of Korean Medical Science, 2022
Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine subtype 2 (TMPRSS2) are key proteins mediating viral entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although gene expressions of ACE2 and TMPRSS2 have been analyzed in various organs and diseases, their soluble forms have been less studied, particularly in ...
Ji-Hyang Lee, Chae Eun Lee, Youngsang Yoo, Eunyong Shin, Jin An, Seo Young Park, Woo-Jung Song, Hyouk-Soo Kwon, You Sook Cho, Hee-Bom Moon, Tae-Bum Kim   +10 more
openaire   +2 more sources

Downregulation of TMPRSS2 mRNA with 48 h stimulated myokine treatment.

, 2022
(a): TMPRSS2 qPCR in 16HBE14o. Real time pcr revealed a 41% reduction of TMPRSS2 mRNA with stimulated myokines. (b): TMPRSS2 qPCR in A549. Stimulated myokine treatment reduced TMPRSS2 gene expression by 75.7%.
Beth Parker (1792180), Deepika Subramanyam (13124113), Hemant K. Roy (13124119), Vaishali Bhardwaj (8658189), Mart Dela Cruz (416088), Sandeep Markan (13124116), Rohit Kumar (2177842)   +6 more
core   +1 more source

Establishment of stable Vero cell lines expressing TMPRSS2 and MSPL: A useful tool for propagating porcine epidemic diarrhea virus in the absence of exogenous trypsin

Virulence, 2020
Porcine epidemic diarrhea virus (PEDV) is the causative agent of porcine epidemic diarrhea, causing substantial economic losses to the swine industry worldwide.
Xiaona Wang, Xinyuan Qiao, Ling Sui, Haiyuan Zhao, Fengsai Li, Yan-Dong Tang, Wen Shi, Yuyao Guo, Yanping Jiang, Li Wang, Han Zhou, Lijie Tang, Yigang Xu, Yijing Li   +13 more
doaj   +1 more source

Detection of TMPRSS2 : ERG fusion gene in circulating prostate cancer cells [PDF]

, 2008
Aim: To investigate the existence of TMPRSS2:ERG fusion gene in circulating tumor cells (CTC) from prostate cancer patients and its potential in monitoring tumor metastasis.
Shaw, Greg, Purkis, Patricia, Young, Bryan D., Oliver, R. Tim D, Kia, Saname, Mao, Xueying, Kudahetti, Sakunthala C., Tsigani, Theodora, James, Sharon Y., Prowse, David M., Lu, Yong Jie, Berney, Dan   +11 more
core   +1 more source

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

, 2022
The SARS-CoV-2 Omicron BA.1 variant emerged in 20211 and has multiple mutations in its spike protein2. Here we show that the spike protein of Omicron has a higher affinity for ACE2 compared with Delta, and a marked change in its antigenicity increases ...
Goonawardane, Niluka, Saito, Akatsuki, Zepeda, Samantha K, Ferreira, Isabella ATM, Rathore, Surabhi, Papa, Guido, Kemp, Steven A, Kimura, Izumi, Abdullahi, Adam, Gerber, Pehuén Pereyra, Meng, Bo, Ikeda, Terumasa, Toyoda, Mako, et al., Yamasoba, Daichi, Fatihi, Saman   +15 more
core   +1 more source

Raman Analysis of RNA Nucleotide Strands From SARS‐CoV‐2 Variants and Subvariants: A Step Forward in the Definition of “Raman Genome”

Advanced Science, EarlyView.
Main Raman signals in RNA, related to helical backbone, ribofuranose ring, and nitrogenous bases, are affected by secondary structures that cause hyperchromic effects and significantly alter the Raman intensity. ABSTRACT Raman spectra of RNA nucleotide strands extracted from 20 SARS‐CoV‐2 strains, including the original Japanese isolate, Alpha, Beta ...
Giuseppe Pezzotti, Yoshiki Yasukochi, Gianluca Angiola, Takaharu Ueno, Saki Ikegami, Rintaro Okawa, Tetsuya Adachi, Wenliang Zhu, Osam Mazda, Alfio Grillo, Koichiro Higasa, Kazu Okuma   +11 more
wiley   +1 more source

Mutations in ace2 gene modulate cytokine levels and alter immune responses in Mycobacterium tuberculosis and SARS-CoV-2 co-infection: a Cameroonian cohort

Frontiers in Immunology
IntroductionSARS-CoV-2 and Mycobacterium tuberculosis (Mtb) share similarities in their modes of transmission, pathophysiological symptoms, and clinical manifestations.
Mary Ngongang Kameni, Mary Ngongang Kameni, Mary Ngongang Kameni, Eric Berenger Tchoupe, Eric Berenger Tchoupe, Severin Donald Kamdem, Severin Donald Kamdem, Nikhil Bhalla, Jean Paul Assam Assam, Arnaud Njuiget Tepa, Fuh Roger Neba, Ranjan Kumar Nanda, Anthony Afum-Adjei Awuah, Anthony Afum-Adjei Awuah, Anthony Afum-Adjei Awuah, John Humphrey Amuasi, John Humphrey Amuasi, John Humphrey Amuasi, Palmer Masumbe Netongo, Palmer Masumbe Netongo, Palmer Masumbe Netongo   +20 more
doaj   +1 more source

Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19

Scientific Reports, 2022
The cell surface serine protease Transmembrane Protease 2 (TMPRSS2) is required to cleave the spike protein of SARS-CoV-2 for viral entry into cells. We determined whether negatively-charged heparin enhanced TMPRSS2 inhibition by alpha-1-antitrypsin (AAT)
Xiyuan Bai, Ashley M. Buckle, Eszter K. Vladar, Edward N. Janoff, Reeti Khare, Diane Ordway, David Beckham, Lorelenn B. Fornis, Abraham Majluf-Cruz, Randolph V. Fugit, Brian M. Freed, Soohyun Kim, Robert A. Sandhaus, Edward D. Chan   +13 more
doaj   +1 more source

An Oral Antiviral Combination Against Severe COVID‐19 Enabled by the Synergistic Mechanisms of Action of Auranofin and Remdesivir

Advanced Science, EarlyView.
FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.
Oyahida Khatun, Rohan Narayan, Santhosh Kambaiah Nagaraj, Rishad Shiraz, Abinaya Kaliappan, Sumandeep Kaur, Ankur Singh, Siva Shanmugam Selvaraj, Gudepalya Renukaiah Rudramurthy, Chakenahalli Naveenkumar, Shridhar Narayanan, Radha Krishan Shandil, Shailly Tomar, Shashank Tripathi   +13 more
wiley   +1 more source