Results 61 to 70 of about 33,857 (224)
TMPRSS2:ETS gene fusions in prostate cancer [PDF]
, 2011 Deep insight on TMPRSS2:ETS gene fusions in prostate ...
Yoshimoto, M +4 more
core +1 more source
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
Frontiers in Microbiology, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a widespread outbreak of highly pathogenic coronavirus disease 2019 (COVID-19). It is therefore important and timely to characterize interactions between the virus and host cell at ...
Jiya Sun +19 more
doaj +1 more source
Canonical Antibodies Adopt Distinct Binding Modes to Recognize Viral Glycan Shields
Advanced Science, EarlyView.Canonical Y‐shaped antibodies recognize viral glycan shields through adaptive Fab assembly states shaped by glycan organization and somatic hypermutation. Structural analyses ofbroadly neutralizing antibodies VRC35 and VRC36 across glycoproteins of HIV‐1, influenza, SARS‐CoV‐2, and Lassa viruses reveal distinct Fab assembly states, spanning monovalent,
Jiaxuan Cheng +71 more
wiley +1 more source
, 2016 (A) Genomic structure of the TMPRSS2–ERG fusion transcripts discovered from deep sequencing data by InFusion. Isoform 3 is a known transcript, while isoforms 1 and 2 are novel. Transcript names are taken from the Ensembl v.68 database.
Alexander Seitz (3372767) +5 more
core +1 more source
Emerging Microbes and Infections, 2022 The novel SARS-CoV-2 Omicron variant (B.1.1.529), first found in early November 2021, has sparked considerable global concern and it has >50 mutations, many of which are known to affect transmissibility or cause immune escape. In this study, we sought to
Hanjun Zhao +13 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Background: Acting as a viral entry for coronavirus to invade human cells, TMPRSS2 has become a target for the prevention and treatment of COVID-19 infection.
Mei Meng +8 more
doaj +1 more source
Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants
Advanced Science, EarlyView.Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer +17 more
wiley +1 more source
Inhibition of Influenza A virus propagation by benzoselenoxanthenes stabilizing TMPRSS2 Gene G-quadruplex and hence down-regulating TMPRSS2 expression [PDF]
Scientific Reports, 2020 AbstractProteolytic cleavage of influenza A virus (IAV) hemagglutinin by host proteases is crucial for virus infectivity and spread. The transmembrane serine protease TMPRSS2 was previously identified as the essential protease that can cleave hemagglutinin of many subtypes of influenza virus and spike protein of coronavirus.
Shen, Li-Wen +6 more
openaire +2 more sources
, 2022 Additional file 10: Table S3. The normalized read counts of TMPRSS2-ERG (e2e4), TMPRSS2-ERG (e1e4), TMPRSS2 and ERG in TCGA after Agrep analysis (1 error allowed)
Zhongqiu Xie (2116327) +8 more
core +1 more source