Results 61 to 70 of about 31,828 (224)

Structural Analysis of Experimental Drugs Binding to the COVID-19 Target TMPRSS2

, 2020
The emergence of SARS-CoV-2 has prompted a worldwide health emergency. There is an urgent need for therapeutics, both through the repurposing of approved drugs and the development of new treatments.
David, Huggins
core   +1 more source

Bromhexine is a potential drug for COVID-19; From hypothesis to clinical trials

Вопросы вирусологии, 2022
COVID-19 (novel coronavirus disease 2019), caused by the SARS-CoV-2 virus, has various clinical manifestations and several pathogenic pathways. Although several therapeutic options have been used to control COVID-19, none of these medications have been ...
S. Bahadoram, B. Keikhaei, M. Bahadoram, M.-R. Mahmoudian-Sani, S. Hassanzadeh, A. Saeedi-Boroujeni, K. Alikhani   +6 more
doaj   +1 more source

Discovery of TMPRSS2 inhibitors from virtual screening [PDF]

, 2020
Abstract The SARS-CoV-2 pandemic has prompted researchers to pivot their efforts to finding antiviral compounds and vaccines. In this study, we focused on the human host cell transmembrane protease serine 2 (TMPRSS2), which plays an important role in the viral life cycle by cleaving the spike protein to initiate ...
Xin Hu, Jonathan H. Shrimp, Hui Guo, Miao Xu, Catherine Z. Chen, Wei Zhu, Alexey Zakharov, Sankalp Jain, Paul Shinn, Anton Simeonov, Matthew D. Hall, Min Shen   +11 more
openaire   +2 more sources

Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19

Scientific Reports, 2022
The cell surface serine protease Transmembrane Protease 2 (TMPRSS2) is required to cleave the spike protein of SARS-CoV-2 for viral entry into cells. We determined whether negatively-charged heparin enhanced TMPRSS2 inhibition by alpha-1-antitrypsin (AAT)
Xiyuan Bai, Ashley M. Buckle, Eszter K. Vladar, Edward N. Janoff, Reeti Khare, Diane Ordway, David Beckham, Lorelenn B. Fornis, Abraham Majluf-Cruz, Randolph V. Fugit, Brian M. Freed, Soohyun Kim, Robert A. Sandhaus, Edward D. Chan   +13 more
doaj   +1 more source

Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester [PDF]

Open Biology, 2020
While initially recognized as causing respiratory disease, the SARS-CoV-2 virus also affects many other organs leading to other complications. It has emerged that advanced age and obesity are risk factors for complications but questions concerning the ...
Bailey A. T. Weatherbee, David M. Glover, Magdalena Zernicka-Goetz   +2 more
doaj   +1 more source

Inhibition of Influenza A virus propagation by benzoselenoxanthenes stabilizing TMPRSS2 Gene G-quadruplex and hence down-regulating TMPRSS2 expression [PDF]

Scientific Reports, 2020
AbstractProteolytic cleavage of influenza A virus (IAV) hemagglutinin by host proteases is crucial for virus infectivity and spread. The transmembrane serine protease TMPRSS2 was previously identified as the essential protease that can cleave hemagglutinin of many subtypes of influenza virus and spike protein of coronavirus.
Shen, Li-Wen, Qian, Man-Qing, Yu, Kai, Narva, Suresh, Yu, Fei, Wu, Yan-Ling, Zhang, Wen   +6 more
openaire   +2 more sources

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

, 2022
The SARS-CoV-2 Omicron BA.1 variant emerged in 20211 and has multiple mutations in its spike protein2. Here we show that the spike protein of Omicron has a higher affinity for ACE2 compared with Delta, and a marked change in its antigenicity increases ...
Goonawardane, Niluka, Saito, Akatsuki, Zepeda, Samantha K, Ferreira, Isabella ATM, Rathore, Surabhi, Papa, Guido, Kemp, Steven A, Kimura, Izumi, Abdullahi, Adam, Gerber, Pehuén Pereyra, Meng, Bo, Ikeda, Terumasa, Toyoda, Mako, et al., Yamasoba, Daichi, Fatihi, Saman   +15 more
core   +1 more source

Single-Cell RNA-seq Reveals Angiotensin-Converting Enzyme 2 and Transmembrane Serine Protease 2 Expression in TROP2+ Liver Progenitor Cells: Implications in Coronavirus Disease 2019-Associated Liver Dysfunction

Frontiers in Medicine, 2021
The recent coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2. COVID-19 was first reported in China (December 2019) and is now prevalent across the globe.
Justine Jia Wen Seow, Rhea Pai, Archita Mishra, Edwin Shepherdson, Tony Kiat Hon Lim, Brian K. P. Goh, Jerry K. Y. Chan, Pierce K. H. Chow, Florent Ginhoux, Florent Ginhoux, Florent Ginhoux, Ramanuj DasGupta, Ankur Sharma, Ankur Sharma, Ankur Sharma   +14 more
doaj   +1 more source

TMPRSS2 overexpression attenuates NCOA7-mediated restriction.

, 2021
(A) A549-ACE2 cells with or without TMPRSS2 were infected with increasing volumes of SARS-CoV-2 Spike pseudotyped vector expressing luciferase (SARS-2). Luciferase activity was measured 48 h post-infection.
David A. Matthews (542987), Michael H. Malim (9415812), Andrew D. Davidson (7828103), Katie J. Doores (346210), Massimo Palmarini (81656), Hataf Khan (10979229), Suzannah J. Rihn (10196153), Carl Graham (9415779), Caroline Goujon (6029021), Stuart J. D. Neil (9415815), Helena Winstone (10979232), Jose M. Jimenez-Guardeño (5658871)   +11 more
core   +1 more source

Immunocytochemical Assessment of ACE2 and TMPRSS2 in Nasopharyngeal Swabs from SARS-CoV-2 Patients

Frontiers in Bioscience-Landmark, 2022
Background: SARS-CoV-2 is a positive-sense single-stranded RNA virus. It is enveloped by four structural proteins. The entry of the virus into the host cells is mediated by spike protein binding to the angiotensin converting enzyme 2 (ACE2) and ...
Karla Beatríz Peña, Josep Gumà, Carmen Guilarte, Lola Delamo, Marc Grifol, Berta Pique, Anna Hernandez, Helena Casteñé, Francesc Riu, David Parada   +9 more
doaj   +1 more source