Results 61 to 70 of about 31,965 (231)

Immunocytochemical Assessment of ACE2 and TMPRSS2 in Nasopharyngeal Swabs from SARS-CoV-2 Patients

Frontiers in Bioscience-Landmark, 2022
Background: SARS-CoV-2 is a positive-sense single-stranded RNA virus. It is enveloped by four structural proteins. The entry of the virus into the host cells is mediated by spike protein binding to the angiotensin converting enzyme 2 (ACE2) and ...
Karla Beatríz Peña, Josep Gumà, Carmen Guilarte, Lola Delamo, Marc Grifol, Berta Pique, Anna Hernandez, Helena Casteñé, Francesc Riu, David Parada   +9 more
doaj   +1 more source

TMPRSS2-ERG gene fusion in prostate cancer [PDF]

Biomedical Papers, 2014
The TMPRSS2-ERG gene fusion is one of the most widely spread chromosomal rearrangements in carcinomas. Since its discovery, a number of studies have examined its diagnostic, prognostic and therapeutic implications for prostate cancer where suitable biomarkers are still lacking. The publication data are inconsistent.
Alena, Burdova, Jan, Bouchal, Spiros, Tavandzis, Zdenek, Kolar   +3 more
openaire   +2 more sources

TMPRSS2 Is an Activating Protease for Respiratory Parainfluenza Viruses [PDF]

Journal of Virology, 2013
ABSTRACT Here, we show that human parainfluenza viruses and Sendai virus (SeV), like other respiratory viruses, use TMPRSS2 for their activation. The membrane fusion proteins of respiratory viruses often possess serine and glutamine residues at the P2 and P3 positions, respectively, but these residues were not critical for cleavage by TMPRSS2.
Masako, Abe, Maino, Tahara, Kouji, Sakai, Hiromi, Yamaguchi, Kazuhiko, Kanou, Kazuya, Shirato, Miyuki, Kawase, Masahiro, Noda, Hirokazu, Kimura, Shutoku, Matsuyama, Hideo, Fukuhara, Katsumi, Mizuta, Katsumi, Maenaka, Yasushi, Ami, Mariko, Esumi, Atsushi, Kato, Makoto, Takeda   +16 more
openaire   +2 more sources

TMPRSS2 gene polymorphism common in East Asians confers decreased COVID-19 susceptibility

Frontiers in Microbiology, 2022
COVID-19 has a wide range of clinical presentations, and the susceptibility to SARS-CoV-2 infection and the mortality rate also vary by region and ethnicity.
Takeshi Sekiya, Yukino Ogura, Hirayasu Kai, Atsushi Kawaguchi, Atsushi Kawaguchi, Atsushi Kawaguchi, Shino Okawa, Mikako Hirohama, Takahiro Kuroki, Wataru Morii, Akira Hara, Yuji Hiramatsu, Shigemi Hitomi, Yasushi Kawakami, Yoshihiro Arakawa, Kazushi Maruo, Shigeru Chiba, Hiromichi Suzuki, Hiroshi Kojima, Hirokazu Tachikawa, Kunihiro Yamagata   +20 more
doaj   +1 more source

Discovery of TMPRSS2 inhibitors from virtual screening [PDF]

, 2020
Abstract The SARS-CoV-2 pandemic has prompted researchers to pivot their efforts to finding antiviral compounds and vaccines. In this study, we focused on the human host cell transmembrane protease serine 2 (TMPRSS2), which plays an important role in the viral life cycle by cleaving the spike protein to initiate ...
Xin Hu, Jonathan H. Shrimp, Hui Guo, Miao Xu, Catherine Z. Chen, Wei Zhu, Alexey Zakharov, Sankalp Jain, Paul Shinn, Anton Simeonov, Matthew D. Hall, Min Shen   +11 more
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The association of ACE1, ACE2, TMPRSS2, IFITM3 and VDR polymorphisms with COVID-19 severity

EXCLI Journal : Experimental and Clinical Sciences, 2022
Genes involved in the regulation of viral recognition and its entry into a host cell have been identified as candidates for genetic association studies on COVID-19 severity.
Zorana Dobrijević, Dragana Robajac, Nikola Gligorijević, Miloš Šunderić, Ana Penezić, Goran Miljuš, Olgica Nedić   +6 more
doaj   +1 more source

TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention? [PDF]

Cancer Discovery, 2020
Abstract TMPRSS2 is both the most frequently altered gene in primary prostate cancer and a critical factor enabling cellular infection by coronaviruses, including SARS-CoV-2. The modulation of its expression by sex steroids could contribute to the male predominance of severe infections, and given that TMPRSS2 has no known indispensable ...
Konrad H. Stopsack, Lorelei A. Mucci, Emmanuel S. Antonarakis, Peter S. Nelson, Philip W. Kantoff   +4 more
openaire   +2 more sources

Paramyxoviruses activation by host proteases in cultures of normal and cancer cells

Вопросы вирусологии, 2017
Multiplication of paramyxovirus Sendai and Newcastle disease virus (NDV) was studied in cultures of normal and tumor cells. Production of noninfectious virus with uncleaved F0 was observed in canine kidney cell line MDCK (line H) and its derivatives ...
O. P. Zhirnov
doaj   +1 more source

Canonical Antibodies Adopt Distinct Binding Modes to Recognize Viral Glycan Shields

Advanced Science, EarlyView.
Canonical Y‐shaped antibodies recognize viral glycan shields through adaptive Fab assembly states shaped by glycan organization and somatic hypermutation. Structural analyses ofbroadly neutralizing antibodies VRC35 and VRC36 across glycoproteins of HIV‐1, influenza, SARS‐CoV‐2, and Lassa viruses reveal distinct Fab assembly states, spanning monovalent,
Jiaxuan Cheng, Evan M. Cale, Amirabbas Maghsoudi, Matthew S. Sutton, Nancy S. Longo, Rebecca A. Gillespie, Lingshu Wang, Ivan Kosik, Sue Chong, Atsuhiro Yasuhara, Tatsiana Bylund, Arne Schön, Prabhanshu Tripathi, Yaroslav Tsybovsky, Haotian Lei, Nicholas C. Morano, Allison B. Lupatkin, Abraham J. Morton, Zabrina C. Lang, Jordan E. Becker, Isabella R. Frascilla, Myungjin Lee, Ning Li, Cuiping Liu, Ryan S. Roark, Chen‐Hsiang Shen, I‐Ting Teng, David J. Van Wazer, Danyi Wang, Lingyuan Wu, Goran Ahlsen, Mike Castro, Haijuan Du, Michael J. Ernandes, Tiansheng Li, Bob C. Lin, Mark K. Louder, Krisha McKee, Jonah S. Merriam, Sijy O'Dell, Li Ou, Sergei Pletnev, David Prikryl, Qi Qiu, Sarah Rubin, Mallika Sastry, Stephen D. Schmidt, Asif Shajahan, Andrea R. Shiakolas, Sanjay Srivatsan, Baoshan Zhang, Qiong Zhou, Mark Connors, Jason G. Gall, Yicheng Guo, Rick K. Huang, Yaoxing Huang, Richard A. Koup, Q. Paula Lei, John R. Mascola, Reda Rawi, Leonid Serebryannyy, Lawrence Shapiro, Zizhang Sheng, David D. Ho, Patrick C. Wilson, Jonathan W. Yewdell, Theodore C. Pierson, Masaru Kanekiyo, Nicole A. Doria‐Rose, Peter D. Kwong, Tongqing Zhou   +71 more
wiley   +1 more source