Results 41 to 50 of about 31,965 (231)
ACE2 and TMPRSS2 Immunolocalization and COVID-19-Related Thyroid Disorder [PDF]
, 2022 SIMPLE SUMMARY: We analyzed the underlying mechanism of thyroidal manifestations in patients with COVID-19 using ACE2 and TMPRSS2 immunostaining. Prior to our work, few studies had investigated the mRNA expression of ACE2 in the thyroid gland.
Han, Ji-Min +23 more
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Journal of Inflammation Research, 2021 Chaobin He,1– 3,* Xin Hua,1,2,4,* Shuxin Sun,1– 3,* Shaolong Li,1,2 Jun Wang,1– 3 Xin Huang1– 3 1Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer ...
He C +5 more
doaj
PCA3 and TMPRSS2: ERG Urine Level as Diagnostic Biomarker of Prostate Cancer [PDF]
, 2023 Syah Mirsya Warli,1,2 Muhammad Haritsyah Warli,3 Fauriski Febrian Prapiska2 1Department of Urology, Faculty of Medicine Universitas Sumatera Utara – Universitas Sumatera Utara Hospital, Medan, North Sumatera, Indonesia; 2Department of Surgery Urology ...
Prapiska FF, Warli SM, Warli MH
core
TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection
Viruses, 2023 The COVID-19 pandemic remains a global health threat and novel antiviral strategies are urgently needed. SARS-CoV-2 employs the cellular serine protease TMPRSS2 for entry into lung cells, and TMPRSS2 inhibitors are being developed for COVID-19 therapy ...
Kristin Metzdorf +13 more
doaj +1 more source
Frontiers in Genetics, 2020 Type 2 transmembrane serine protease (TMPRSS2) is a new member of the serine proteases, and studies have shown that TMPRSS2 plays a role in the occurrence of prostate malignancies and is closely related to the occurrence of the coronavirus disease 2019 ...
Lianxiang Luo +8 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2022 TMPRSS2 is a transmembrane serine protease and plays a pivotal role in coronavirus disease 2019 (COVID-19). However, the correlation of TMPRSS2 with prognosis and immune infiltration in tumors has not yet been explored.
Xinhua Xiao +8 more
doaj +1 more source
Computational Identification of a Putative Allosteric Binding Pocket in TMPRSS2 [PDF]
Frontiers in Molecular Biosciences, 2021 Camostat, nafamostat, and bromhexine are inhibitors of the transmembrane serine protease TMPRSS2. The inhibition of TMPRSS2 has been shown to prevent the viral infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other viruses.
Jacopo Sgrignani +2 more
openaire +3 more sources
ACE-2, TMPRSS2 and Beyond; Promising Targets and Tools for COVID-19 Prophylaxis and Treatment
Bezmiâlem Science, 2020 Several repurposing drugs and ongoing vaccine researches to combat Coronavirus Disease-19 (COVID-19) are testing clinically, worldwide. COVID-19 caused by severe acute respiratory failure syndrome-CoV-2, uses angiotensin-converting enzyme 2 (ACE-2) as a ...
Akçahan GEPDİREMEN, Meltem KUMAŞ
doaj +1 more source
The Role of TMPRSS2 and TMPRSS2- Inhibitors in Cell Entry Mechanism of COVID-19
Journal of Regenerative Biology and Medicine, 2020 The enzymes trypsin, furine and other proprotein convertases, cathepsin, transmembrane proteases (TMPRSS) and elastases play a role in the cell entry of coronaviruses (Coronaviridae). The proteases TMPRSS2 and TMPRSS11a, which are abundant in the respiratory tract and expressed on cell surfaces, promote the entry of SARS-CoV-1 viruses.
openaire +1 more source
The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells. [PDF]
, 2005 TMPRSS2 is a type II transmembrane-bound serine protease that has gained interest owing to its highly localized expression in the prostate and its overexpression in neoplastic prostate epithelium.
Hawthorne, Susan +18 more
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