Results 41 to 50 of about 33,857 (224)
Impact of ACE2 and TMPRSS2 Expression in Patients With Preeclampsia
In Vivo, 2023 As maternal morbidity and mortality during pregnancy have increased during the COVID-19 pandemic, studies on pregnancy-related complications from SARS-CoV-2 infection are being actively conducted. Considering that pregnant women with COVID-19 may develop a preeclampsia (PE)-like syndrome, it is necessary to differentiate it from PE because true PE can ...
Ji Eun, Park +7 more
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Detection of tmprss2-erg and tmprss2-egr1 gene fusion in prostate cancer from a Chinese population [PDF]
Egyptian Journal of Medical Human Genetics, 2020 Abstract Background TMPRSS2: ETS gene fusion occurs recurrently in a high proportion of prostate cancer (PCa) patients in Western countries. However, for Chinese PCa patients, no solid conclusion could be drawn from the present studies, as the results varied considerably between the limited reports.
Changqing Xu +8 more
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Special Considerations on Insulin Resistance Induced Hyperandrogenemia in Women with Polycystic Ovary Syndrome: A Prominent COVID-19 Risk Factor [PDF]
International Journal of Molecular and Cellular Medicine, 2022 Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) infecting mechanism depends on hosting angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) as essential components and androgens as regulators for inducing the
Jamshid Roozbeh +4 more
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Evidence of SARS-CoV-2 Transmission Through the Ocular Route
Clinical Ophthalmology, 2021 Jing-Yu Qu, Hua-Tao Xie, Ming-Chang Zhang Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of ChinaCorrespondence: Ming-Chang Zhang; Hua-Tao ...
Qu JY, Xie HT, Zhang MC
doaj
The Role of TMPRSS2 and TMPRSS2- Inhibitors in Cell Entry Mechanism of COVID-19
Journal of Regenerative Biology and Medicine, 2020 The enzymes trypsin, furine and other proprotein convertases, cathepsin, transmembrane proteases (TMPRSS) and elastases play a role in the cell entry of coronaviruses (Coronaviridae). The proteases TMPRSS2 and TMPRSS11a, which are abundant in the respiratory tract and expressed on cell surfaces, promote the entry of SARS-CoV-1 viruses.
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48 h stimulated myokine treatment downregulated TMPRSS2 protein levels in 16HBE14o.
, 2022 Anti-TMPRSS2 ELISA revealed a ~32% reduction of TMPRSS2 protein with stimulated myokine treatment.
Beth Parker (1792180) +6 more
core +1 more source
Bromhexine is a potential drug for COVID-19; From hypothesis to clinical trials
Вопросы вирусологии, 2022 COVID-19 (novel coronavirus disease 2019), caused by the SARS-CoV-2 virus, has various clinical manifestations and several pathogenic pathways. Although several therapeutic options have been used to control COVID-19, none of these medications have been ...
S. Bahadoram +6 more
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Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester [PDF]
Open Biology, 2020 While initially recognized as causing respiratory disease, the SARS-CoV-2 virus also affects many other organs leading to other complications. It has emerged that advanced age and obesity are risk factors for complications but questions concerning the ...
Bailey A. T. Weatherbee +2 more
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In silico inhibitor docking for human TMPRSS2
, 2020 TMPRSS2 is a human protein that SARS-CoV-2 uses for viral entry and is potential target for developing prophylaxis treatment. Using a unique structural phylogenetic approach, we identified several candidate compounds that have the capability to inhibit ...
Velez, G (via Mendeley Data) +1 more
core +2 more sources
Frontiers in Medicine, 2021 The recent coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2. COVID-19 was first reported in China (December 2019) and is now prevalent across the globe.
Justine Jia Wen Seow +14 more
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