Results 21 to 30 of about 31,965 (231)
In Silico Study on Spice-Derived Antiviral Phytochemicals Against SARS-CoV-2 TMPRSS2 Target [PDF]
, 2020 We predicted the structure of TMPRSS2 (transmembrane protease serine 2), a host protein that truncates spike protein of SARS-CoV-2. Then we docked 18 anti-viral compounds found in Indian spices against the catalytic domain of TMPRSS2.
Amit, Jaiswal +2 more
core +1 more source
ACE2 and TMPRSS2 partially overlap. [PDF]
, 2022 Autofluorescence in grey (488 channel), co-staining in red (647 channel), and purple (730 channel), with overlapping regions in pink (colorblind-proof).
Kim M. Bouwman (4112605) +13 more
core +1 more source
Virtual Drug Repurposing Study Against SARS-CoV-2 TMPRSS2 Target [PDF]
, 2020 Currently, the world suffers from a new coronavirus SARS-CoV-2 that causes COVID-19. Therefore, there is a need for the urgent development of novel drugs and vaccines for COVID-19.
Serdar, Durdagi
core +1 more source
Downregulation of TMPRSS2 mRNA with 48 h stimulated myokine treatment. [PDF]
, 2022 (a): TMPRSS2 qPCR in 16HBE14o. Real time pcr revealed a 41% reduction of TMPRSS2 mRNA with stimulated myokines. (b): TMPRSS2 qPCR in A549. Stimulated myokine treatment reduced TMPRSS2 gene expression by 75.7%.
Beth Parker (1792180) +6 more
core +1 more source
Structural Analysis of Experimental Drugs Binding to the COVID-19 Target TMPRSS2 [PDF]
, 2020 The emergence of SARS-CoV-2 has prompted a worldwide health emergency. There is an urgent need for therapeutics, both through the repurposing of approved drugs and the development of new treatments.
David, Huggins
core +1 more source
Effect of bromhexine on clinical outcomes and mortality in COVID-19 patients: A randomized clinical trial [PDF]
BioImpacts, 2020 Introduction: Bromhexine is a potential therapeutic option in COVID-19, but no data from a randomized clinical trial has been available. The present study aimed to evaluate the efficacy of bromhexine in intensive care unit (ICU) admission, mechanical ...
Khalil Ansarin +10 more
doaj +1 more source
Frontiers in Medicine, 2020 Coronavirus Disease 2019 (COVID-19) has created a global pandemic. Global epidemiological results show that elderly men are susceptible to infection of COVID-19. The difference in the number of cases reported by gender increases progressively in favor of
Weihang He +13 more
doaj +1 more source
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity [PDF]
, 2022 The SARS-CoV-2 Omicron BA.1 variant emerged in 20211 and has multiple mutations in its spike protein2. Here we show that the spike protein of Omicron has a higher affinity for ACE2 compared with Delta, and a marked change in its antigenicity increases ...
Goonawardane, Niluka +15 more
core +1 more source
Tokyo Women's Medical University Journal, 2021 Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has a wide range of clinical manifestations, including acute respiratory distress syndrome, severe inflammation, abnormal blood coagulation, and ...
Ayako Nakamura-Ishizu, Fumio Nakamura
doaj +1 more source
Genetic variants in TMPRSS2 and Structure of SARS-CoV-2 spike glycoprotein and TMPRSS2 complex [PDF]
, 2020 Abstract SARS-CoV-2, a highly transmittable pathogen has infected over 3.8 million people around the globe. The spike glycoprotein of SARS-CoV-2 engages host ACE2 for adhesion, TMPRSS2 for activation and entry. With the aid of whole-exome sequencing, we report a variant rs12329760 in TMPRSS2
Ravikanth Vishnubhotla +7 more
openaire +1 more source