Results 21 to 30 of about 33,857 (224)
A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon.
PLoS ONE, 2016 Fusion between TMPRSS2 and ERG, placing ERG under the control of the TMPRSS2 promoter, is the most frequent genetic alteration in prostate cancer, present in 40-50% of cases.
Dong Gao +11 more
doaj +2 more sources
Protease-Responsive Potential-Tunable AIEgens for Cell Selective Imaging of TMPRSS2 and Accurate Inhibitor Screening [PDF]
, 2023 Transmembrane protease serine 2 (TMPRSS2) is a plasma membrane protease that activates both spike protein of coronaviruses for cell entry and oncogenic signaling pathways for tumor progression. TMPRSS2 inhibition can reduce cancer invasion and metastasis
Aaron F. Carlin +17 more
core +2 more sources
A Quantum Chemical Study on the Anti-SARS-CoV-2 Activity of TMPRSS2 Inhibitors [PDF]
, 2023 Nafamostat and camostat are known to inhibit the spike protein-mediated fusion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by forming a covalent bond with the human transmembrane serine protease 2 (TMPRSS2) enzyme.
Takeshi, Yanai +5 more
core +2 more sources
PLoS ONEIt has been postulated from a combination of evidence that a sudden increase in COVID-19 cases among pediatric patients after onset of the Omicron wave was attributed to a reduced requirement for TMPRSS2-mediated entry in pediatric airways with lower ...
Sosuke Kakee +7 more
doaj +2 more sources
Intelligent Programmable Membrane Nanosponge for Early Virus Blocking. [PDF]
Adv Sci (Weinh)A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Chen Z +17 more
europepmc +2 more sources
In Silico Study on Spice-Derived Antiviral Phytochemicals Against SARS-CoV-2 TMPRSS2 Target [PDF]
, 2020 We predicted the structure of TMPRSS2 (transmembrane protease serine 2), a host protein that truncates spike protein of SARS-CoV-2. Then we docked 18 anti-viral compounds found in Indian spices against the catalytic domain of TMPRSS2.
Amit, Jaiswal +2 more
core +1 more source
Frontiers in Oncology, 2021 BackgroundCoronavirus disease 2019 (COVID-19) has rapidly spread worldwide. Systematic analysis of lung cancer survivors at molecular and clinical levels is warranted to understand the disease course and clinical characteristics.MethodsA single-center ...
Qianqian Wang +31 more
doaj +1 more source
Structural Analysis of Experimental Drugs Binding to the COVID-19 Target TMPRSS2 [PDF]
, 2020 The emergence of SARS-CoV-2 has prompted a worldwide health emergency. There is an urgent need for therapeutics, both through the repurposing of approved drugs and the development of new treatments.
David, Huggins
core +1 more source
Frontiers in Genetics, 2022 The new coronavirus (2019-nCoV) is an emerging pathogen that can cause severe respiratory infections in humans. It is worth noting that many of the affected COVID-19 patients have malignant tumors.
Yiming Meng +5 more
doaj +1 more source
Effect of bromhexine on clinical outcomes and mortality in COVID-19 patients: A randomized clinical trial [PDF]
BioImpacts, 2020 Introduction: Bromhexine is a potential therapeutic option in COVID-19, but no data from a randomized clinical trial has been available. The present study aimed to evaluate the efficacy of bromhexine in intensive care unit (ICU) admission, mechanical ...
Khalil Ansarin +10 more
doaj +1 more source