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TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection
Viruses, 2023 The COVID-19 pandemic remains a global health threat and novel antiviral strategies are urgently needed. SARS-CoV-2 employs the cellular serine protease TMPRSS2 for entry into lung cells, and TMPRSS2 inhibitors are being developed for COVID-19 therapy ...
Kristin Metzdorf +2 more
exaly +3 more sources
TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells. [PDF]
PLoS ONE, 2015 The cellular protease TMPRSS2 cleaves and activates the influenza virus hemagglutinin (HA) and TMPRSS2 expression is essential for viral spread and pathogenesis in mice.
Pawel Zmora +3 more
doaj +2 more sources
Oncology Reports, 2007 Recently, gene fusions between the androgen responsive gene TMPRSS2 and members of the ETS-family of DNA-binding transcription factor genes were found in prostate cancer. Recurrent fusions were identified between the 5'-noncoding region of TMPRSS2 and ERG, or less frequently ETV1 or ETV4, resulting in overexpression of normal or truncated ETS-proteins.
Marta, Winnes +3 more
openaire +4 more sources
Increased ACE2 and TMPRSS2 expression in ulcerative colitis [PDF]
Pathology - Research and PracticeUlcerative colitis (UC) is a cryptogenic inflammatory bowel disease, and there is an urgent need to elucidate its pathogenesis. ACE2 and TMPRSS2, the entry molecules of SARS-CoV-2, are reportedly associated with the disease; however, no consensus has been reached yet.
Yuichiro Hamamoto +7 more
openaire +4 more sources
Expression of <i>ACE2</i> and <i>TMPRSS2</i> and the severity of COVID-19. [PDF]
Biomed RepSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19), uses the angiotensin-converting enzyme 2 (ACE2) receptor and transmembrane serine protease 2 (TMPRSS2) to enter host cells. Variability in gene expression of these entry factors has been hypothesized to influence susceptibility ...
Sanches De Carvalho S +8 more
europepmc +3 more sources
Detection of SARS-CoV-2 infection in thyroid follicular cells from a COVID-19 autopsy series
European Thyroid Journal, 2023 Objective: To understand whether thyroid cells can be directly infected by the SARS-CoV-2 virus and to establish a putative correlation with the expression of the host entry machinery: ACE-2, TMPRSS2, and furin.
Sofia Macedo +13 more
doaj +1 more source
Jurnal Ilmiah Biosaintropis (Bioscience-Tropic), 2023 COVID-19 is a disease caused by viruses of the coronavirus class that are known to enter humans through the Angiotensin Coverting Enzyme (ACE II) receptor protein and transmembrane serine protease (TMPRSS 2).
Yoni Rina Bintari, Dian Novita Wulandari
doaj +1 more source
Frontiers in Pharmacology, 2022 Background: To date, no oral antiviral drug has proven to be beneficial in hospitalized patients with COVID-19.Methods: In this randomized, controlled, open-label, platform trial, we randomly assigned patients ≥18 years hospitalized with COVID-19 ...
M. Karolyi +21 more
doaj +1 more source
Optimization of East Java Propolis Extraction as Anti SARS-Cov-2 by Molecular Docking Study
Jurnal Ilmu dan Teknologi Hasil Ternak, 2022 The purpose of this research is to obtain the optimum propolis extraction method using microwave extraction so as to produce anti-SARS CoV-2 compounds. The research method used was experimental with a completely randomized factorial design consisting of ...
Sofia Aulia Hidayat +3 more
doaj +1 more source
The role of proteases in the invasion of SARS-CoV-2 virus into human host cells
Journal of Current Biomedical Reports, 2021 The new coronavirus, which originally broke out in Wuhan, China, in December 2019, increase quickly around the world, causing a pandemic all over the world. The virus uses its spike protein to enter the human host cells.
Maryam Saeidi, Fatemeh Rouhollah
doaj +1 more source