Results 11 to 20 of about 33,857 (224)
Potential Compounds for the Inhibition of TMPRSS2 [PDF]
, 2020 The ongoing search to contain and control the spread of COVID-19 disease focuses on discovering drugs or vaccines that can play an essential role in treating this contagious disease. This paper focuses on natural compounds that can play a vital role in the treatment of Covid-19.
Muhammad Roomi, Yaser Khan
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TMPRSS2 Impacts Cytokine Expression in Murine Dendritic Cells
Biomedicines, 2023 Background: The transmembrane protease serine 2 (TMPRSS2) proteolytically activates the envelope proteins of several viruses for viral entry via membrane fusion and is therefore an interesting and promising target for the development of broad-spectrum ...
Sandra Gunne +6 more
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ACE-2, TMPRSS2 and Beyond; Promising Targets and Tools for COVID-19 Prophylaxis and Treatment
Bezmiâlem Science, 2020 Several repurposing drugs and ongoing vaccine researches to combat Coronavirus Disease-19 (COVID-19) are testing clinically, worldwide. COVID-19 caused by severe acute respiratory failure syndrome-CoV-2, uses angiotensin-converting enzyme 2 (ACE-2) as a ...
Akçahan GEPDİREMEN, Meltem KUMAŞ
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TMPRSS2 is a functional receptor for human coronavirus HKU1
Nature, 2023 Four endemic seasonal human coronaviruses causing common colds circulate worldwide: HKU1, 229E, NL63 and OC43 (ref. 1). After binding to cellular receptors, coronavirus spike proteins are primed for fusion by transmembrane serine protease 2 (TMPRSS2) or endosomal cathepsins2-9.
Saunders, Nell +28 more
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Targeting TMPRSS2 in SARS-CoV-2 Infection [PDF]
Mayo Clinic Proceedings, 2020 Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has rapidly caused a global pandemic associated with a novel respiratory infection: coronavirus disease-19 (COVID-19). Angiotensin-converting enzyme-2 (ACE2) is necessary to facilitate SARS-CoV-2 infection, but-owing to its essential metabolic roles-it may be difficult to target it in ...
Baughn, Linda B. +5 more
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TMPRSS2 in microbial interactions: Insights from HKU1 and TcsH.
PLoS PathogensTransmembrane Serine Protease 2 (TMPRSS2), known primarily for its role as a protease, has emerged as a critical receptor for microbial agents such as human coronavirus HKU1 and exotoxin TcsH. HKU1 utilizes both sialoglycan and TMPRSS2 for cellular entry,
Zhengyang Pan, Daoqun Li, Leiliang Zhang
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Oncology Reports, 2007 Recently, gene fusions between the androgen responsive gene TMPRSS2 and members of the ETS-family of DNA-binding transcription factor genes were found in prostate cancer. Recurrent fusions were identified between the 5'-noncoding region of TMPRSS2 and ERG, or less frequently ETV1 or ETV4, resulting in overexpression of normal or truncated ETS-proteins.
Marta, Winnes +3 more
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TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells. [PDF]
PLoS ONE, 2015 The cellular protease TMPRSS2 cleaves and activates the influenza virus hemagglutinin (HA) and TMPRSS2 expression is essential for viral spread and pathogenesis in mice.
Pawel Zmora +3 more
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TMPRSS2 regulates ACE2 trafficking and shedding [PDF]
Abstract Angiotensin-converting enzyme 2 (ACE2) functions as the receptor for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus utilizes the cellular endocytic machinery for entry by binding to defined residues on ACE2 with its spike protein (S protein), whose activation requires a priming process by another ...
Yue Qiu +6 more
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TMPRSS2 (transmembrane protease, serine 2) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on TMPRSS2 (transmembrane protease, serine 2), with data on DNA, on the protein encoded, and where the gene is implicated.
Y Park, Park, Y
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