Results 31 to 40 of about 33,857 (224)
Virtual Drug Repurposing Study Against SARS-CoV-2 TMPRSS2 Target [PDF]
, 2020 Currently, the world suffers from a new coronavirus SARS-CoV-2 that causes COVID-19. Therefore, there is a need for the urgent development of novel drugs and vaccines for COVID-19.
Serdar, Durdagi
core +1 more source
Genetic variants in TMPRSS2 and Structure of SARS-CoV-2 spike glycoprotein and TMPRSS2 complex [PDF]
, 2020 Abstract SARS-CoV-2, a highly transmittable pathogen has infected over 3.8 million people around the globe. The spike glycoprotein of SARS-CoV-2 engages host ACE2 for adhesion, TMPRSS2 for activation and entry. With the aid of whole-exome sequencing, we report a variant rs12329760 in TMPRSS2
Ravikanth Vishnubhotla +7 more
openaire +1 more source
Tokyo Women's Medical University Journal, 2021 Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has a wide range of clinical manifestations, including acute respiratory distress syndrome, severe inflammation, abnormal blood coagulation, and ...
Ayako Nakamura-Ishizu, Fumio Nakamura
doaj +1 more source
Frontiers in Medicine, 2020 Coronavirus Disease 2019 (COVID-19) has created a global pandemic. Global epidemiological results show that elderly men are susceptible to infection of COVID-19. The difference in the number of cases reported by gender increases progressively in favor of
Weihang He +13 more
doaj +1 more source
Publication trend of TMPRSS2 as SARS-CoV-2 receptor during the COVID-19 pandemic [PDF]
Pharmaciana, 2023 The Coronavirus Disease 2019 (COVID-19) pandemic has not yet been fully under public health control, which is still currently impacting a large number of people worldwide in 2023.
Lalu Muhammad Irham +5 more
doaj +1 more source
The human Transmembrane Protease Serine 2 is necessary for the production of Group 2 influenza A virus pseudotypes [PDF]
, 2013 The monomer of influenza haemagglutinin is synthesized as a single polypeptide precursor that during maturation is cleaved by proteases into two active subunits. Other studies have demonstrated that the human Transmembrane Protease Serine 2 (TMPRSS2) can
Ferrara, Francesca +7 more
core +1 more source
Virtual Screening on Marine Natural Products for Discovering TMPRSS2 Inhibitors
Frontiers in Chemistry, 2021 Although SARS-CoV-2 entry to cells strictly depends on angiotensin-converting enzyme 2 (ACE2), the virus also needs transmembrane serine protease 2 (TMPRSS2) for its spike protein priming.
Mehdi Mahmudpour +4 more
doaj +1 more source
Renal Carcinoma Is Associated With Increased Risk of Coronavirus Infections
Frontiers in Molecular Biosciences, 2020 Background: The current COVID-19 pandemic has affected most severely people with old age, or with comorbidities like hypertension, diabetes mellitus, and cancer.
Satyendra C. Tripathi +6 more
doaj +1 more source
Searching for Novel COVID19 Treatments: Towards Covalent TMPRSS2 Inhibitors [PDF]
ChemMedChemWe designed, synthesised, and evaluated new guanidine derivatives as potential covalent inhibitors of TMPRSS2, a key protease for SARS‐CoV‐2 entry. Computational studies showed that some compounds have improved binding over nafamostat. However, experimentally none effectively blocked viral entry in cell assays, indicating further optimisation is needed.
Minneci M +6 more
europepmc +2 more sources
Journal of Inflammation Research, 2021 Chaobin He,1– 3,* Xin Hua,1,2,4,* Shuxin Sun,1– 3,* Shaolong Li,1,2 Jun Wang,1– 3 Xin Huang1– 3 1Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer ...
He C +5 more
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