Results 31 to 40 of about 31,828 (224)

Impact of TMPRSS2 Expression, Mutation Prognostics, and Small Molecule (CD, AD, TQ, and TQFL12) Inhibition on Pan-Cancer Tumors and Susceptibility to SARS-CoV-2

Molecules, 2022
As a cellular protease, transmembrane serine protease 2 (TMPRSS2) plays roles in various physiological and pathological processes, including cancer and viral entry, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Jiewen Fu, Shuguang Liu, Qi Tan, Zhiying Liu, Jie Qian, Ting Li, Jiaman Du, Binghui Song, Dabing Li, Lianmei Zhang, Jiayue He, Kan Guo, Baixu Zhou, Hanchun Chen, Shangyi Fu, Xiaoyan Liu, Jingliang Cheng, Tao He, Junjiang Fu   +18 more
doaj   +1 more source

Growing concerns on male reproductive health amidst COVID-19 pandemic

Journal of Family Medicine and Primary Care, 2022
Blood–testis barrier is body's innate mechanism to defend germ cells by creating a physical and immunological barrier. But some viral infections are known to evade it.
Megha Agrawal, Vikas Kumar, Gyan Vardhan
doaj   +1 more source

High Expression of ACE2 and TMPRSS2 at the Resection Margin Makes Lung Cancer Survivors Susceptible to SARS-CoV-2 With Unfavorable Prognosis

Frontiers in Oncology, 2021
BackgroundCoronavirus disease 2019 (COVID-19) has rapidly spread worldwide. Systematic analysis of lung cancer survivors at molecular and clinical levels is warranted to understand the disease course and clinical characteristics.MethodsA single-center ...
Qianqian Wang, Liangyu Li, Liangyu Li, Tianyu Qu, Jie Li, Jie Li, Lingxiang Wu, Lingxiang Wu, Kening Li, Kening Li, Ziyu Wang, Ziyu Wang, Mengyan Zhu, Mengyan Zhu, Bin Huang, Bin Huang, Wei Wu, Wei Wu, Min Wu, Min Wu, Rong Ding, Rong Ding, Zhihong Zhang, Qianghu Wang, Qianghu Wang, Xinyi Xia, Xinyi Xia, Xinyi Xia, Pengping Li, Pengping Li, Zhi Zhang, Renhua Guo   +31 more
doaj   +1 more source

A Pan-Cancer In Silico Analysis of the COVID-19 Internalization Protease: Transmembrane Proteaseserine-2

Frontiers in Genetics, 2022
The new coronavirus (2019-nCoV) is an emerging pathogen that can cause severe respiratory infections in humans. It is worth noting that many of the affected COVID-19 patients have malignant tumors.
Yiming Meng, Jing Sun, Guirong Zhang, Tao Yu, Haozhe Piao, Haozhe Piao   +5 more
doaj   +1 more source

Effect of bromhexine on clinical outcomes and mortality in COVID-19 patients: A randomized clinical trial [PDF]

BioImpacts, 2020
Introduction: Bromhexine is a potential therapeutic option in COVID-19, but no data from a randomized clinical trial has been available. The present study aimed to evaluate the efficacy of bromhexine in intensive care unit (ICU) admission, mechanical ...
Khalil Ansarin, Ramin Tolouian, Mohammadreza Ardalan, Ali Taghizadieh, Mojtaba Varshochi, Soheil Teimouri, Tahere Vaezi, Hamed Valizadeh, Parviz Saleh, Saeid Safiri, Kenneth R. Chapman   +10 more
doaj   +1 more source

Impact of ACE2 and TMPRSS2 Expression in Patients With Preeclampsia

In Vivo, 2023
As maternal morbidity and mortality during pregnancy have increased during the COVID-19 pandemic, studies on pregnancy-related complications from SARS-CoV-2 infection are being actively conducted. Considering that pregnant women with COVID-19 may develop a preeclampsia (PE)-like syndrome, it is necessary to differentiate it from PE because true PE can ...
Ji Eun, Park, Dae Hyun, Song, Yu-Min, Kim, Hyen Chul, Jo, Jong Chul, Baek, Hyoeun, Kim, Juseok, Yang, Hyo Jung, An   +7 more
openaire   +2 more sources

Detection of tmprss2-erg and tmprss2-egr1 gene fusion in prostate cancer from a Chinese population [PDF]

Egyptian Journal of Medical Human Genetics, 2020
Abstract Background TMPRSS2: ETS gene fusion occurs recurrently in a high proportion of prostate cancer (PCa) patients in Western countries. However, for Chinese PCa patients, no solid conclusion could be drawn from the present studies, as the results varied considerably between the limited reports.
Changqing Xu, Jindan Luo, Mengmeng Wang, Yin Wang, Zhaojing Chen, Yifei Cao, Yu Hong, Xianrong Xu, Jun Yang   +8 more
openaire   +2 more sources

Impact of SARS-CoV-2 on Male Reproductive Health: A Review of the Literature on Male Reproductive Involvement in COVID-19

Frontiers in Medicine, 2020
Coronavirus Disease 2019 (COVID-19) has created a global pandemic. Global epidemiological results show that elderly men are susceptible to infection of COVID-19. The difference in the number of cases reported by gender increases progressively in favor of
Weihang He, Xiaoqiang Liu, Xiaoqiang Liu, Liang Feng, Liang Feng, Situ Xiong, Yulei Li, Luyao Chen, Yu Li, Gongxian Wang, Gongxian Wang, Dongshui Li, Bin Fu, Bin Fu   +13 more
doaj   +1 more source

Secondary Publication: The Pathophysiology of COVID-19 (Coronavirus Disease 2019) Caused by the Infection of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2)

Tokyo Women's Medical University Journal, 2021
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has a wide range of clinical manifestations, including acute respiratory distress syndrome, severe inflammation, abnormal blood coagulation, and ...
Ayako Nakamura-Ishizu, Fumio Nakamura
doaj   +1 more source

Genetic variants in TMPRSS2 and Structure of SARS-CoV-2 spike glycoprotein and TMPRSS2 complex [PDF]

, 2020
Abstract SARS-CoV-2, a highly transmittable pathogen has infected over 3.8 million people around the globe. The spike glycoprotein of SARS-CoV-2 engages host ACE2 for adhesion, TMPRSS2 for activation and entry. With the aid of whole-exome sequencing, we report a variant rs12329760 in TMPRSS2
Ravikanth Vishnubhotla, Naveen Vankadari, Vijayasarathy Ketavarapu, Ramars Amanchy, Steffie Avanthi, Govardhan Bale, Duvvur Nageshwar Reddy, Mitnala Sasikala   +7 more
openaire   +1 more source