The human Transmembrane Protease Serine 2 is necessary for the production of Group 2 influenza A virus pseudotypes [PDF]
, 2013 The monomer of influenza haemagglutinin is synthesized as a single polypeptide precursor that during maturation is cleaved by proteases into two active subunits. Other studies have demonstrated that the human Transmembrane Protease Serine 2 (TMPRSS2) can
Ferrara, Francesca +7 more
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TMPRSS2 overexpression attenuates NCOA7-mediated restriction. [PDF]
, 2021 (A) A549-ACE2 cells with or without TMPRSS2 were infected with increasing volumes of SARS-CoV-2 Spike pseudotyped vector expressing luciferase (SARS-2). Luciferase activity was measured 48 h post-infection.
David A. Matthews (542987) +11 more
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Publication trend of TMPRSS2 as SARS-CoV-2 receptor during the COVID-19 pandemic [PDF]
Pharmaciana, 2023 The Coronavirus Disease 2019 (COVID-19) pandemic has not yet been fully under public health control, which is still currently impacting a large number of people worldwide in 2023.
Lalu Muhammad Irham +5 more
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TMPRSS2-ERG fusion isoforms. [PDF]
, 2016 (A) Genomic structure of the TMPRSS2–ERG fusion transcripts discovered from deep sequencing data by InFusion. Isoform 3 is a known transcript, while isoforms 1 and 2 are novel. Transcript names are taken from the Ensembl v.68 database.
Alexander Seitz (3372767) +5 more
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DataSheet1_Virtual Screening on Marine Natural Products for Discovering TMPRSS2 Inhibitors.zip [PDF]
, 2021 Although SARS-CoV-2 entry to cells strictly depends on angiotensin-converting enzyme 2 (ACE2), the virus also needs transmembrane serine protease 2 (TMPRSS2) for its spike protein priming.
Maryam Farrokhnia (1668937) +3 more
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Renal Carcinoma Is Associated With Increased Risk of Coronavirus Infections
Frontiers in Molecular Biosciences, 2020 Background: The current COVID-19 pandemic has affected most severely people with old age, or with comorbidities like hypertension, diabetes mellitus, and cancer.
Satyendra C. Tripathi +6 more
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Spontaneous Binding of Potential COVID-19 Drugs to Human Serine Protease TMPRSS2 [PDF]
, 2020 Effective treatment or vaccine is not yet available for combating SARS coronavirus 2 (SARSCoV-2) that caused the COVID-19 pandemic. Recent studies showed that two drugs, Camostat and Nafamostat, might be repurposed to treat COVID-19 by inhibiting human ...
Haixia, Zhu +5 more
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Virtual Screening on Marine Natural Products for Discovering TMPRSS2 Inhibitors
Frontiers in Chemistry, 2021 Although SARS-CoV-2 entry to cells strictly depends on angiotensin-converting enzyme 2 (ACE2), the virus also needs transmembrane serine protease 2 (TMPRSS2) for its spike protein priming.
Mehdi Mahmudpour +4 more
doaj +1 more source
Impact of ACE2 and TMPRSS2 Expression in Patients With Preeclampsia
In Vivo, 2023 As maternal morbidity and mortality during pregnancy have increased during the COVID-19 pandemic, studies on pregnancy-related complications from SARS-CoV-2 infection are being actively conducted. Considering that pregnant women with COVID-19 may develop a preeclampsia (PE)-like syndrome, it is necessary to differentiate it from PE because true PE can ...
Ji Eun, Park +7 more
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Detection of tmprss2-erg and tmprss2-egr1 gene fusion in prostate cancer from a Chinese population [PDF]
Egyptian Journal of Medical Human Genetics, 2020 Abstract Background TMPRSS2: ETS gene fusion occurs recurrently in a high proportion of prostate cancer (PCa) patients in Western countries. However, for Chinese PCa patients, no solid conclusion could be drawn from the present studies, as the results varied considerably between the limited reports.
Changqing Xu +8 more
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