Results 51 to 60 of about 31,965 (231)
In silico inhibitor docking for human TMPRSS2 [PDF]
, 2020 TMPRSS2 is a human protein that SARS-CoV-2 uses for viral entry and is potential target for developing prophylaxis treatment. Using a unique structural phylogenetic approach, we identified several candidate compounds that have the capability to inhibit ...
Velez, G
core +3 more sources
Virus‐Mediated Self‐Assembly of Functional Cyclodextrins for Antiviral Inhibition
Angewandte Chemie, EarlyView.A sialic acid (SA)‐functionalized cyclodextrin (CD) self‐assembles on SARS‐CoV‐2 through ligand–receptor recognition, nucleating cooperative supramolecular polymer growth that blocks infection. The adaptive assembly requires both ligand binding and host–guest polymerization, remains active across variants, and can be tuned by coassembly, establishing ...
Pedro J. Hernando +10 more
wiley +2 more sources
Evidence of SARS-CoV-2 Transmission Through the Ocular Route
Clinical Ophthalmology, 2021 Jing-Yu Qu, Hua-Tao Xie, Ming-Chang Zhang Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of ChinaCorrespondence: Ming-Chang Zhang; Hua-Tao ...
Qu JY, Xie HT, Zhang MC
doaj
ACE2 and TMPRSS2 immunolocalization and oral manifestations of COVID‐19 [PDF]
Oral Diseases, 2022 Abstract Objectives Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) entry into the host cells depends on the expression of angiotensin‐converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). We investigated the distribution of ACE2‐ and TMPRSS2‐expressing cells in
Gi Cheol Park +11 more
openaire +2 more sources
Bromhexine is a potential drug for COVID-19; From hypothesis to clinical trials
Вопросы вирусологии, 2022 COVID-19 (novel coronavirus disease 2019), caused by the SARS-CoV-2 virus, has various clinical manifestations and several pathogenic pathways. Although several therapeutic options have been used to control COVID-19, none of these medications have been ...
S. Bahadoram +6 more
doaj +1 more source
Prevalence and prognostic significance of TMPRSS2-ERG gene fusion in lymph node positive prostate cancers. [PDF]
, 2014 BACKGROUND TMPRSS2-ERG gene fusion is the most frequent genetic alteration in prostate cancer. However, information about its distribution in lymph node positive prostate cancers and the prognostic significance in these advanced tumors is unknown ...
Seiler, Roland +7 more
core +1 more source
Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester [PDF]
Open Biology, 2020 While initially recognized as causing respiratory disease, the SARS-CoV-2 virus also affects many other organs leading to other complications. It has emerged that advanced age and obesity are risk factors for complications but questions concerning the ...
Bailey A. T. Weatherbee +2 more
doaj +1 more source
ACE2 & TMPRSS2 Expressions in Head & Neck Tissues: A Systematic Review [PDF]
, 2020 International audienceTo review the data regarding the expression of angiotensin converting enzyme-2 (ACE2) and transmembrane protease serine-2 (TMPRSS2) in head and neck tissue.
Barillari, Maria, R +23 more
core +3 more sources
Frontiers in Medicine, 2021 The recent coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2. COVID-19 was first reported in China (December 2019) and is now prevalent across the globe.
Justine Jia Wen Seow +14 more
doaj +1 more source
Scientific Reports, 2022 The cell surface serine protease Transmembrane Protease 2 (TMPRSS2) is required to cleave the spike protein of SARS-CoV-2 for viral entry into cells. We determined whether negatively-charged heparin enhanced TMPRSS2 inhibition by alpha-1-antitrypsin (AAT)
Xiyuan Bai +13 more
doaj +1 more source