Results 51 to 60 of about 33,857 (224)
Immunocytochemical Assessment of ACE2 and TMPRSS2 in Nasopharyngeal Swabs from SARS-CoV-2 Patients
Frontiers in Bioscience-Landmark, 2022 Background: SARS-CoV-2 is a positive-sense single-stranded RNA virus. It is enveloped by four structural proteins. The entry of the virus into the host cells is mediated by spike protein binding to the angiotensin converting enzyme 2 (ACE2) and ...
Karla Beatríz Peña +9 more
doaj +1 more source
Frontiers in Genetics, 2020 Type 2 transmembrane serine protease (TMPRSS2) is a new member of the serine proteases, and studies have shown that TMPRSS2 plays a role in the occurrence of prostate malignancies and is closely related to the occurrence of the coronavirus disease 2019 ...
Lianxiang Luo +8 more
doaj +1 more source
TMPRSS2-ERG gene fusion in prostate cancer [PDF]
Biomedical Papers, 2014 The TMPRSS2-ERG gene fusion is one of the most widely spread chromosomal rearrangements in carcinomas. Since its discovery, a number of studies have examined its diagnostic, prognostic and therapeutic implications for prostate cancer where suitable biomarkers are still lacking. The publication data are inconsistent.
Alena, Burdova +3 more
openaire +2 more sources
TMPRSS2 gene polymorphism common in East Asians confers decreased COVID-19 susceptibility
Frontiers in Microbiology, 2022 COVID-19 has a wide range of clinical presentations, and the susceptibility to SARS-CoV-2 infection and the mortality rate also vary by region and ethnicity.
Takeshi Sekiya +20 more
doaj +1 more source
TMPRSS2 Is an Activating Protease for Respiratory Parainfluenza Viruses [PDF]
Journal of Virology, 2013 ABSTRACT Here, we show that human parainfluenza viruses and Sendai virus (SeV), like other respiratory viruses, use TMPRSS2 for their activation. The membrane fusion proteins of respiratory viruses often possess serine and glutamine residues at the P2 and P3 positions, respectively, but these residues were not critical for cleavage by TMPRSS2.
Masako, Abe +16 more
openaire +2 more sources
The association of ACE1, ACE2, TMPRSS2, IFITM3 and VDR polymorphisms with COVID-19 severity
EXCLI Journal : Experimental and Clinical Sciences, 2022 Genes involved in the regulation of viral recognition and its entry into a host cell have been identified as candidates for genetic association studies on COVID-19 severity.
Zorana Dobrijević +6 more
doaj +1 more source
Discovery of TMPRSS2 inhibitors from virtual screening [PDF]
, 2020 Abstract The SARS-CoV-2 pandemic has prompted researchers to pivot their efforts to finding antiviral compounds and vaccines. In this study, we focused on the human host cell transmembrane protease serine 2 (TMPRSS2), which plays an important role in the viral life cycle by cleaving the spike protein to initiate ...
Xin Hu +11 more
openaire +2 more sources
Paramyxoviruses activation by host proteases in cultures of normal and cancer cells
Вопросы вирусологии, 2017 Multiplication of paramyxovirus Sendai and Newcastle disease virus (NDV) was studied in cultures of normal and tumor cells. Production of noninfectious virus with uncleaved F0 was observed in canine kidney cell line MDCK (line H) and its derivatives ...
O. P. Zhirnov
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
PCA3 and TMPRSS2: ERG Urine Level as Diagnostic Biomarker of Prostate Cancer
, 2023 Syah Mirsya Warli,1,2 Muhammad Haritsyah Warli,3 Fauriski Febrian Prapiska2 1Department of Urology, Faculty of Medicine Universitas Sumatera Utara – Universitas Sumatera Utara Hospital, Medan, North Sumatera, Indonesia; 2Department of Surgery Urology ...
Prapiska FF, Warli SM, Warli MH
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