Results 81 to 90 of about 31,965 (231)

Protease-Responsive Potential-Tunable AIEgens for Cell Selective Imaging of TMPRSS2 and Accurate Inhibitor Screening [PDF]

, 2023
Transmembrane protease serine 2 (TMPRSS2) is a plasma membrane protease that activates both spike protein of coronaviruses for cell entry and oncogenic signaling pathways for tumor progression. TMPRSS2 inhibition can reduce cancer invasion and metastasis
Aaron F. Carlin, Aaron F. Carlin (6167324), Alex E. Clark, Wonjun Yim (9706711), Yu-Ci Chang (13206250), Raina M. Borum, Alex E. Clark (10130709), Tengyu He, Jesse V. Jokerst, Zhicheng Jin (2119099), Tengyu He (4951795), Jesse V. Jokerst (801981), Wonjun Yim, Raina M. Borum (10880567), Yong Cheng, Yong Cheng (237211), Yu-Ci Chang, Zhicheng Jin   +17 more
core   +1 more source

Characterization and immunogenicity of nanoparticle vaccines displaying embecovirus spike proteins

Biotechnology Progress, EarlyView.
Virus‐like particle vaccines displaying spike proteins from OC43, HKU1 A, and HKU1 B were evaluated in mice for their ability to elicit antibodies against the spike proteins from OC43, HKU1 A, HKU1 B, and HKU1 C. Abstract Endemic human coronaviruses OC43 and HKU1 cause widespread respiratory infections and can be associated with severe illness in ...
Peter J. Halfmann, Augustine Duffy, Alex Wee, Noah Anderson, Jackson Terrell, Yoshihiro Kawaoka, Ravi S. Kane   +6 more
wiley   +1 more source

Mutations in ace2 gene modulate cytokine levels and alter immune responses in Mycobacterium tuberculosis and SARS-CoV-2 co-infection: a Cameroonian cohort

Frontiers in Immunology
IntroductionSARS-CoV-2 and Mycobacterium tuberculosis (Mtb) share similarities in their modes of transmission, pathophysiological symptoms, and clinical manifestations.
Mary Ngongang Kameni, Mary Ngongang Kameni, Mary Ngongang Kameni, Eric Berenger Tchoupe, Eric Berenger Tchoupe, Severin Donald Kamdem, Severin Donald Kamdem, Nikhil Bhalla, Jean Paul Assam Assam, Arnaud Njuiget Tepa, Fuh Roger Neba, Ranjan Kumar Nanda, Anthony Afum-Adjei Awuah, Anthony Afum-Adjei Awuah, Anthony Afum-Adjei Awuah, John Humphrey Amuasi, John Humphrey Amuasi, John Humphrey Amuasi, Palmer Masumbe Netongo, Palmer Masumbe Netongo, Palmer Masumbe Netongo   +20 more
doaj   +1 more source

Establishment of stable Vero cell lines expressing TMPRSS2 and MSPL: A useful tool for propagating porcine epidemic diarrhea virus in the absence of exogenous trypsin

Virulence, 2020
Porcine epidemic diarrhea virus (PEDV) is the causative agent of porcine epidemic diarrhea, causing substantial economic losses to the swine industry worldwide.
Xiaona Wang, Xinyuan Qiao, Ling Sui, Haiyuan Zhao, Fengsai Li, Yan-Dong Tang, Wen Shi, Yuyao Guo, Yanping Jiang, Li Wang, Han Zhou, Lijie Tang, Yigang Xu, Yijing Li   +13 more
doaj   +1 more source

Phytochemicals and Health Benefits of American Ginseng (Panax quinquefolius L.): Current Knowledge and Future Perspectives

Food Safety and Health, EarlyView.
This review summarizes the chemical constituents and functional characteristics of American ginseng, aiming to provide references for its development and application. ABSTRACT American ginseng, a perennial herbaceous plant, is recognized for its significant medicinal properties and has attracted considerable attention due to its diverse phytochemical ...
Wei Geng, Ning Zhou, Jinqian Yu, Yanling Geng, Xiao Wang, Yannan Chen   +5 more
wiley   +1 more source

Enzima TMPRSS2 [PDF]

Revista de Ciência Elementar, 2021
Maria Ramos, Pedro Fernandes, Filipa Santos   +2 more
openaire   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

FAM107A loss facilitates TTK‐OPTN‐mediated mitophagy to drive docetaxel resistance in castration‐resistant prostate cancer

Interdisciplinary Medicine, EarlyView.
In the progression of docetaxel resistance, downregulation of FAM107A releases its transcriptional repression of TTK, leading to TTK upregulation. TTK enhances the interaction and phosphorylation of OPTN. This activates mitophagy in tumor cells, facilitates clearance of damaged mitochondria, reduces intracellular reactive oxygen species accumulation ...
Yishan Zhang, Fan Zou, Mingdong Wang, Chenyue Wu, Yingwei Xie, Yongjun Quan, Wei Yan, Yupeng Zheng, Lianhua Li, Yuexin Liu, Jian Yu, Hao Ping   +11 more
wiley   +1 more source

Systematic analysis of genomic alterations in prostate cancer [PDF]

, 2011
PhDProstate cancer is the most common male cancer in Western countries. The genetic mechanism underlying its initiation and progression is still unclear.
Mao, Xueying
core  

Low concentrations of siRNA TMPRSS2-ERG III and IV impair TMPRSS2-ERG oncogene and oncoprotein levels but not cell viability. [PDF]

, 2015
VCaP cells were transfected for 72h from 2.5 nM to 50 nM with siRNA TMPRSS2-ERG III, siRNA TMPRSS2-ERG IV or siRNA Control. a. RT-qPCR analysis: relative TMPRSS2-ERG fusion variants III and IV mRNA levels were analysed and compared to non-treated cells ...
Quentin Rousseau (733381), Liliane Massaad-Massade (347698), Didier Desmaële (2520874), Patrick Couvreur (554924), Giorgia Urbinati (554921), Hubert Chapuis (554922), Hafiz Muhammad Ali (554920)   +6 more
core   +1 more source