Results 81 to 90 of about 31,828 (224)

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

The use of equine influenza pseudotypes for serological screening [PDF]

, 2012
Standard assays used for influenza serology present certain practical issues, such as inter-laboratory variability, complex protocols and the necessity for handling certain virus strains in high biological containment facilities.
Ferrara, Francesca, Böttcher-Friebertshäuser, Eva, Temperton, Nigel J., Scott, Simon D., Temperton, Nigel, Daly, Janet, Molesti, Eleonora, Scott, Simon   +7 more
core  

Characterization and immunogenicity of nanoparticle vaccines displaying embecovirus spike proteins

Biotechnology Progress, EarlyView.
Virus‐like particle vaccines displaying spike proteins from OC43, HKU1 A, and HKU1 B were evaluated in mice for their ability to elicit antibodies against the spike proteins from OC43, HKU1 A, HKU1 B, and HKU1 C. Abstract Endemic human coronaviruses OC43 and HKU1 cause widespread respiratory infections and can be associated with severe illness in ...
Peter J. Halfmann, Augustine Duffy, Alex Wee, Noah Anderson, Jackson Terrell, Yoshihiro Kawaoka, Ravi S. Kane   +6 more
wiley   +1 more source

Gene of the month: TMPRSS2 (transmembrane serine protease 2) [PDF]

Journal of Clinical Pathology, 2020
Transmembrane serine protease 2 is encoded by the TMPRSS2 gene. The gene is widely conserved and has two isoforms, both being autocatalytically activated from the inactive zymogen form. A fusion gene between the TMPRSS2 gene and ERG (erythroblast-specific-related gene), an oncogenic transcription factor, is the most common chromosomal aberration ...
Thunders, Michelle, Delahunt, Brett
openaire   +2 more sources

Comparative Transcriptome Analysis Reveals the Intensive Early Stage Responses of Host Cells to SARS-CoV-2 Infection

Frontiers in Microbiology, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a widespread outbreak of highly pathogenic coronavirus disease 2019 (COVID-19). It is therefore important and timely to characterize interactions between the virus and host cell at ...
Jiya Sun, Jiya Sun, Fei Ye, Aiping Wu, Aiping Wu, Ren Yang, Mei Pan, Mei Pan, Jie Sheng, Jie Sheng, Wenjie Zhu, Wenjie Zhu, Longfei Mao, Longfei Mao, Ming Wang, Zanxian Xia, Baoying Huang, Wenjie Tan, Taijiao Jiang, Taijiao Jiang   +19 more
doaj   +1 more source

Engineering Bisubstrates to Target m6Am RNA Methyltransferases: Synthesis and Computational Studies

Chemistry – A European Journal, EarlyView.
Use of the convertible nucleoside approach to synthesize m6Am RNA methyltransferase bisubstrates. This methodology allows for the introduction of modifications on the SAM analog moiety and the RNA substrate part, including the introduction of a cap analog by click chemistry.
Yoann Colas, Laurent Le Corre, Mélanie Ethève‐Quelquejeu, Emmanuelle Braud   +3 more
wiley   +1 more source

SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cells

Emerging Microbes and Infections, 2022
The novel SARS-CoV-2 Omicron variant (B.1.1.529), first found in early November 2021, has sparked considerable global concern and it has >50 mutations, many of which are known to affect transmissibility or cause immune escape. In this study, we sought to
Hanjun Zhao, Lu Lu, Zheng Peng, Lin-Lei Chen, Xinjin Meng, Chuyuan Zhang, Jonathan Daniel Ip, Wan-Mui Chan, Allen Wing-Ho Chu, Kwok-Hung Chan, Dong-Yan Jin, Honglin Chen, Kwok-Yung Yuen, Kelvin Kai-Wang To   +13 more
doaj   +1 more source

Phytochemicals and Health Benefits of American Ginseng (Panax quinquefolius L.): Current Knowledge and Future Perspectives

Food Safety and Health, EarlyView.
This review summarizes the chemical constituents and functional characteristics of American ginseng, aiming to provide references for its development and application. ABSTRACT American ginseng, a perennial herbaceous plant, is recognized for its significant medicinal properties and has attracted considerable attention due to its diverse phytochemical ...
Wei Geng, Ning Zhou, Jinqian Yu, Yanling Geng, Xiao Wang, Yannan Chen   +5 more
wiley   +1 more source

The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells.

, 2005
TMPRSS2 is a type II transmembrane-bound serine protease that has gained interest owing to its highly localized expression in the prostate and its overexpression in neoplastic prostate epithelium.
Hawthorne, Susan, Zijlstra, A, Zijlstra, Andries, Hawthorne, Susan J., Hawthorne, S, Hooper, J., Wilson, Susan K., Quigley, J, Wilson, S, Greer, B, Walker, Brian, Zijlstra, A., Quigley, J.P., Quigley, James, Hooper, John D., Hooper, J, Walker, B, Wilson, S., Greer, Brett   +18 more
core   +1 more source

In silico inhibitor docking for human TMPRSS2

, 2020
TMPRSS2 is a human protein that SARS-CoV-2 uses for viral entry and is potential target for developing prophylaxis treatment. Using a unique structural phylogenetic approach, we identified several candidate compounds that have the capability to inhibit ...
Velez, G
core   +2 more sources