Results 101 to 110 of about 31,828 (224)

Genetic Predictors of Progression and Skin Rash in Japanese mCSPC Patients Treated With Apalutamide: CUARTET Study

Cancer Science, EarlyView.
In patients with mCSPC treated with apalutamide plus ADT, baseline ctDNA predicted earlier progression to CRPC and worse overall survival. Exploratory genome‐wide analysis identified 12 SNPs associated with apalutamide‐related skin rash. ABSTRACT Despite promising evidence of the efficacy of the androgen deprivation therapy (ADT) plus apalutamide in ...
Masaki Shiota, Taku Naiki, Koji Hatano, Akira Yokomizo, Hiroaki Tsuchiya, Yoko Takahashi, Taku Nakayama, Masaki Yoshida, Hirotsugu Uemura   +8 more
wiley   +1 more source

H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice

Virology Journal, 2020
The host cell protease TMPRSS2 cleaves the influenza A virus (IAV) hemagglutinin (HA). Several reports have described resistance of Tmprss2 −/− knock-out (KO) mice to IAV infection but IAV of the H2 subtype have not been examined yet.
Ruth Lydia Olga Lambertz, Ingo Gerhauser, Inga Nehlmeier, Sabine Gärtner, Michael Winkler, Sarah Rebecca Leist, Heike Kollmus, Stefan Pöhlmann, Klaus Schughart   +8 more
doaj   +1 more source

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

TMPRSS2:ETS gene fusions in prostate cancer [PDF]

, 2011
Deep insight on TMPRSS2:ETS gene fusions in prostate ...
Yoshimoto, M, Squire, JA, Boag, AH, Park, PC, Williams, JL   +4 more
core   +1 more source

The burden of COVID‐19 in hospitalized people with diabetes mellitus in Brazil: Insights from four years of the pandemic

Diabetic Medicine, EarlyView.
Abstract Aims Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is more severe in people with diabetes mellitus due to immune dysfunction, exacerbated inflammation and increased risk of co‐morbidities and mortality.
Taís Mendes Camargo, Bianca Aparecida Siqueira, Luiz Felipe Azevedo Marques, Lucas Silva Mello, Fernando Augusto Lima Marson   +4 more
wiley   +1 more source

Prostate cancer risk regions at 8q24 and 17q24 are differentially associated with somatic TMPRSS2:ERG fusion status [PDF]

, 2016
Molecular and epidemiological differences have been described between TMPRSS2:ERG fusion-positive and fusion-negative prostate cancer (PrCa). Assuming two molecularly distinct subtypes, we have examined 27 common PrCa risk variants, previously identified
Geybels, Milan S., PRACTICAL consortium,, Stanford, Janet L, Wach, Sven, Teixeira, Manuel R, Cannon-Albright, Lisa, Kuefer, Rainer, Perner, S, Teixeira, MR, Teixeira, Manuel R., Krause, H, Al Olama, AA, Geybels, MS, Tammela, TLJ, Benlloch, Sara, Ostrander, Elaine A, Krause, Hans, Parker, C, Cooper, Colin S, Goh, CL, Jerónimo, C, Schleutker, Johanna, Rau, TT, Geybels, Milan S, Benlloch, S, Fitzgerald, Liesel M., Hofer, Matthias D, Henrique, R, Stanford, JL, Jerónimo, Carmen, Visakorpi, Tapio, Hofer, MD, Hofer, Matthias D., Weikert, S, Cooper, CS, Henrique, Rui, Lieb, Verena, Cannon-Albright, L, Wach, S, FitzGerald, Liesel M, Ostrander, Elaine A., Kuefer, R, Herkommer, K, Easton, Doug F, Visakorpi, T, Flohr, P, FitzGerald, LM, Schleutker, J, Rinckleb, AE, Lieb, V, Vogel, Walther, Goh, Chee L, Eeles, Rosalind A, Hoegel, Josef, Leinonen, Katri A, Easton, DF, Parker, Chris, Cooper, Colin S., Ostrander, EA, Herkommer, Kathleen, Rubin, Mark A., Kote-Jarai, Zsofia, Rau, Tilman T., Maier, C, Rubin, MA, Goh, Chee L., Tammela, Teuvo L J, Vogel, W, Paulo, P, Kote-Jarai, Z, Leinonen, KA, Amin Al Olama, Ali, Maier, Christiane, Flohr, Penny, Easton, Doug F., Luedeke, Manuel, Wahlfors, Tiina, Rubin, Mark A, Edwards, Sandra, McCarthy, F, Luedeke, M, Agarwal, AM, Weikert, Steffen, Eeles, RA, Wahlfors, T, Rau, Tilman, Rinckleb, Antje E, Agarwal, Archana M, Tammela, Teuvo L. J., Hoegel, J, Leinonen, Katri A., Paulo, Paula, McCarthy, Frank, Perner, Sven, Edwards, S, Rinckleb, Antje E., Agarwal, Archana M., Eeles, Rosalind A.   +97 more
core   +1 more source

A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon.

PLoS ONE, 2016
Fusion between TMPRSS2 and ERG, placing ERG under the control of the TMPRSS2 promoter, is the most frequent genetic alteration in prostate cancer, present in 40-50% of cases.
Dong Gao, Yu Zhan, Wei Di, Amanda R Moore, Jessica J Sher, Youxin Guan, Shangqian Wang, Zeda Zhang, Devan A Murphy, Charles L Sawyers, Ping Chi, Yu Chen   +11 more
doaj   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Addressing Sex and Gender Bias in COVID-19 Epidemiology in Bangladesh

Journal of Agriculture, Food and Environment, 2021
Sex and gender are recognized as a vital factor in the infectious disease epidemiology,and disease outcomes,and these two factors also appear to hold for severe acute respiratory syndrome (SARS-CoV-2)infection.
M. A. Islam
doaj   +1 more source

Spatial transcriptomics reveals clonal relationships between intraductal carcinoma and adjacent invasive prostate cancer

Histopathology, EarlyView.
Spatial transcriptomics of six prostate samples reveals a close clonal relationship between high‐grade Prostatic Intraepithelial Neoplasia (HGPIN), Intraductal carcinoma (IDC) and adjacent invasive glands. In three samples, adjacent invasive glands had more copy number variants than HGPIN and IDC. Adjacent invasive glands were also placed at the end of
Hridya Harikumar, Myrthe de Waard‐van Baardwijk, Marit de Haan, Gregory van Beek, Karishma Lila, Martin E van Royen, Thierry PP van den Bosch, Mathijs A Sanders, Eric Bindels, Andrew Stubbs, Geert JLH van Leenders   +10 more
wiley   +1 more source