Results 11 to 20 of about 43,824 (207)

TMPRSS2 Impacts Cytokine Expression in Murine Dendritic Cells

Biomedicines, 2023
Background: The transmembrane protease serine 2 (TMPRSS2) proteolytically activates the envelope proteins of several viruses for viral entry via membrane fusion and is therefore an interesting and promising target for the development of broad-spectrum ...
Sandra Gunne, Marie Schwerdtner, Marina Henke, Ann-Kathrin Schneider, Lucas Keutmann, Eva Böttcher-Friebertshäuser, Susanne Schiffmann   +6 more
doaj   +3 more sources

TMPRSS2 in microbial interactions: Insights from HKU1 and TcsH.

PLoS Pathogens
Transmembrane Serine Protease 2 (TMPRSS2), known primarily for its role as a protease, has emerged as a critical receptor for microbial agents such as human coronavirus HKU1 and exotoxin TcsH. HKU1 utilizes both sialoglycan and TMPRSS2 for cellular entry,
Zhengyang Pan, Daoqun Li, Leiliang Zhang
doaj   +3 more sources

Quantitative expression of TMPRSS2 transcript in prostate tumor cells reflects TMPRSS2–ERG fusion status [PDF]

Prostate Cancer and Prostatic Diseases, 2009
TMPRSS2-ERG fusion is the most common oncogenic rearrangement in prostate cancer (CaP). Owing to this chromosomal rearrangement one TMPRSS2 allele loses its promoter, and one of the ETS-related gene (ERG) alleles gains that promoter leading to its overexpression in these tumor cells.
Mwamukonda, Kuwong, Chen, Yongmei, Ravindranath, Lakshmi, Furusato, Bungo, Hu, Ying, Sterbis, Joseph, Osborn, David, Rosner, Inger, Sesterhenn, Isabell A., McLeod, David G., Srivastava, Shiv, Petrovics, Gyorgy   +11 more
openaire   +2 more sources

Targeting TMPRSS2 in SARS-CoV-2 Infection [PDF]

Mayo Clinic Proceedings, 2020
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has rapidly caused a global pandemic associated with a novel respiratory infection: coronavirus disease-19 (COVID-19). Angiotensin-converting enzyme-2 (ACE2) is necessary to facilitate SARS-CoV-2 infection, but-owing to its essential metabolic roles-it may be difficult to target it in ...
Baughn, Linda B., Sharma, Neeraj, Elhaik, Eran, Sekulic, Aleksandar, Bryce, Alan H., Fonseca, Rafael   +5 more
openaire   +2 more sources

Algebraic Comparison of Partial Lists in Bioinformatics [PDF]

, 2010
The outcome of a functional genomics pipeline is usually a partial list of genomic features, ranked by their relevance in modelling biological phenotype in terms of a classification or regression model.
A Gobbi, A Kalousis, A Kossenkov, A Sboner, AC Haury, AL Boulesteix, Arkady B. Khodursky, B Di Camillo, B Efron, B Efron, B Efron, B Schowe, C Cortes, C Cortes, C Furlanello, C Schneider, C Schneider, C Soneson, C Yao, Cesare Furlanello, Consortium The MicroArray Quality Control (MAQC), D Albanese, D Cai, D Corrada, D Critchlow, D Saari, D Witten, G Guzzetta, G Jurman, G Jurman, G Lance, G Lance, G Smyth, Giuseppe Jurman, GS Cheon, I Guyon, I Jeffery, I Lönnstedt, J Bar-Ilan, J Borda, J Chen, J Ioannidis, J Neter, J Storey, L Ein-Dor, L Kuncheva, L Yu, L Zhang, M Desarkar, M Kauers, M Kauers, M Kendall, M Schimek, M Schimek, M Slawski, M Villarino, M Villarino, O Bousquet, P Baldi, P Diaconis, P Diaconis, P Hall, P Hall, P Krízek, PC Boutros, R Fagin, R Gentleman, R Graham, R Pearson, R Pique-Regi, R Pique-Regi, R Simon, Roberto Visintainer, S Abramov, S Dudoit, S Lin, S Lin, S Mukherjee, S Setlur, S Simićc, S Vanderlooy, Samantha Riccadonna, SK Lau, T Bø, T Calders, V Tusher, Visintainer, W Fury, W Hoeffding, W Shi, X Wang, X Yang, Y Xiao, Y Xiao, Z He   +94 more
core   +13 more sources

Secondary Publication: The Pathophysiology of COVID-19 (Coronavirus Disease 2019) Caused by the Infection of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2)

Tokyo Women's Medical University Journal, 2021
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has a wide range of clinical manifestations, including acute respiratory distress syndrome, severe inflammation, abnormal blood coagulation, and ...
Ayako Nakamura-Ishizu, Fumio Nakamura
doaj   +1 more source

Impact of SARS-CoV-2 on Male Reproductive Health: A Review of the Literature on Male Reproductive Involvement in COVID-19

Frontiers in Medicine, 2020
Coronavirus Disease 2019 (COVID-19) has created a global pandemic. Global epidemiological results show that elderly men are susceptible to infection of COVID-19. The difference in the number of cases reported by gender increases progressively in favor of
Weihang He, Xiaoqiang Liu, Xiaoqiang Liu, Liang Feng, Liang Feng, Situ Xiong, Yulei Li, Luyao Chen, Yu Li, Gongxian Wang, Gongxian Wang, Dongshui Li, Bin Fu, Bin Fu   +13 more
doaj   +1 more source

Detection of tmprss2-erg and tmprss2-egr1 gene fusion in prostate cancer from a Chinese population [PDF]

Egyptian Journal of Medical Human Genetics, 2020
Abstract Background TMPRSS2: ETS gene fusion occurs recurrently in a high proportion of prostate cancer (PCa) patients in Western countries. However, for Chinese PCa patients, no solid conclusion could be drawn from the present studies, as the results varied considerably between the limited reports.
Changqing Xu, Jindan Luo, Mengmeng Wang, Yin Wang, Zhaojing Chen, Yifei Cao, Yu Hong, Xianrong Xu, Jun Yang   +8 more
openaire   +2 more sources

Detection of TMPRSS2 : ERG fusion gene in circulating prostate cancer cells [PDF]

, 2008
Creative Commons Attribution-NonCommercial-Share Alike 3.0 license (CC BY-NC SA)Aim: To investigate the existence of TMPRSS2:ERG fusion gene in circulating tumor cells (CTC) from prostate cancer patients and its potential in monitoring tumor metastasis ...
Bryan D. Young, Dan Berney, David M. Prowse, Greg Shaw, Jemal A, Lin B, Patricia Purkis, Pelkey TJ, R. Tim D. Oliver, Sakunthala C. Kudahetti, Saname Kia, Sharon Y. James, Theodora Tsigani, Ulbright TM., Winnes M, Xueying Mao, Yong-Jie Lu   +16 more
core   +1 more source

TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells. [PDF]

PLoS ONE, 2015
The cellular protease TMPRSS2 cleaves and activates the influenza virus hemagglutinin (HA) and TMPRSS2 expression is essential for viral spread and pathogenesis in mice.
Pawel Zmora, Anna-Sophie Moldenhauer, Heike Hofmann-Winkler, Stefan Pöhlmann   +3 more
doaj   +1 more source