Virtual Screening on Marine Natural Products for Discovering TMPRSS2 Inhibitors
Frontiers in Chemistry, 2021 Although SARS-CoV-2 entry to cells strictly depends on angiotensin-converting enzyme 2 (ACE2), the virus also needs transmembrane serine protease 2 (TMPRSS2) for its spike protein priming.
Mehdi Mahmudpour +4 more
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Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression [PDF]
, 2015 background: There is an acute need to uncover biomarkers that reflect the molecular pathologies, underpinning prostate cancer progression and poor patient outcome.
Baillie, G. S. +12 more
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Discovery of TMPRSS2 inhibitors from virtual screening [PDF]
, 2020 AbstractThe SARS-CoV-2 pandemic has prompted researchers to pivot their efforts to finding antiviral compounds and vaccines. In this study, we focused on the human host cell transmembrane protease serine 2 (TMPRSS2), which plays an important role in the viral life cycle by cleaving the spike protein to initiate membrane fusion. TMPRSS2 is an attractive
Xin Hu +11 more
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Renal Carcinoma Is Associated With Increased Risk of Coronavirus Infections
Frontiers in Molecular Biosciences, 2020 Background: The current COVID-19 pandemic has affected most severely people with old age, or with comorbidities like hypertension, diabetes mellitus, and cancer.
Satyendra C. Tripathi +6 more
doaj +1 more source
The molecular basis for ethnic variation and histological subtype differences in prostate cancer. [PDF]
, 2013 Prostate cancer is a common malignancy among men in Western countries. Recently the morbidity and mortality of prostate cancer increase dramatically in several oriental countries including China.
Goldstein, Andrew S +2 more
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TMPRSS2-ERG gene fusion in prostate cancer [PDF]
Biomedical Papers, 2014 The TMPRSS2-ERG gene fusion is one of the most widely spread chromosomal rearrangements in carcinomas. Since its discovery, a number of studies have examined its diagnostic, prognostic and therapeutic implications for prostate cancer where suitable biomarkers are still lacking. The publication data are inconsistent.
Alena, Burdova +3 more
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Publication trend of TMPRSS2 as SARS-CoV-2 receptor during the COVID-19 pandemic [PDF]
Pharmaciana, 2023 The Coronavirus Disease 2019 (COVID-19) pandemic has not yet been fully under public health control, which is still currently impacting a large number of people worldwide in 2023.
Lalu Muhammad Irham +5 more
doaj +1 more source
Journal of Inflammation Research, 2021 Chaobin He,1– 3,* Xin Hua,1,2,4,* Shuxin Sun,1– 3,* Shaolong Li,1,2 Jun Wang,1– 3 Xin Huang1– 3 1Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer ...
He C +5 more
doaj
A Systematic Review of therapeutic agents for the treatment of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) [PDF]
, 2019 Background The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was first described in 2012 and attracted a great international attention due to multiple healthcare associated outbreaks.
Al-Ali, Anfal Y. +2 more
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TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection
Viruses, 2023 The COVID-19 pandemic remains a global health threat and novel antiviral strategies are urgently needed. SARS-CoV-2 employs the cellular serine protease TMPRSS2 for entry into lung cells, and TMPRSS2 inhibitors are being developed for COVID-19 therapy ...
Kristin Metzdorf +13 more
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