Results 101 to 110 of about 683,828 (283)

Preparation of a multiple antigen glycopeptide (MAG) carrying the Tn antigen. A possible approach to a synthetic carbohydrate vaccine.

, 1997
International audienceThe glycosidic tumor-associated Tn antigen was conjugated to a lysine backbone containing a helper T-cell epitope in order to activate immune responses specific for some types of carcinomas.
Osinaga, E., Bay, S., Lo-Man, R., Cantacuzène, D., Nakada, H., Leclerc, C., HIROSHI NAKADA, RICHARD LO-MAN, EDUARDO OSINAGA, DANIELE CANTACUZENE, CLAUDE LECLERC, SYLVIE BAY, Leclerc, Céline   +12 more
core   +1 more source

Bacterial backpacks for targeted delivery of piezoelectric nanoparticles to enhance sonodynamic immunotherapy

BMEMat, EarlyView.
Leveraging bacterial hypoxia targeting, KBTO NPs accumulate at the tumor site. Under the ultrasound irradiation, KBTO NPs produce reactive oxygen species to kill tumor cells and eliminate bacteria, preventing overgrowth and inflammation. The lysed bacteria act as antigens to trigger antitumor immunity and further enhanced by the immune checkpoint ...
Chongyang Liu, Haohui Zhu, Huaibin Yu, Xijun Zhang, Zhiqin Lei, Wenjing Xu, Xinyu Zhao, Ming Wu, Long Yang, Juanjuan Liu, Zhengbao Zha, Xinghui Si, Jianjun Yuan   +12 more
wiley   +1 more source

Truncated O-glycosylation in metastatic triple-negative breast cancer reveals a gene expression signature associated with extracellular matrix and proteolysis

Scientific Reports
Breast cancer (BC) is the leading cause of death by cancer in women worldwide. Triple-negative (TN) BC constitutes aggressive and highly metastatic tumors associated with shorter overall survival of patients compared to other BC subtypes. The Tn antigen,
María Florencia Festari, Eugenio Jara, Monique Costa, Andrés Iriarte, Teresa Freire   +4 more
doaj   +1 more source

Exposure‐Response Analyses of Datopotamab Deruxtecan (Dato‐DXd), a TROP2‐Directed Antibody‐Drug Conjugate, in Advanced Non‐small Cell Lung Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Exposure‐response analyses supported a favorable benefit‐risk profile of Dato‐DXd at 6 mg/kg Q3W in patients with advanced nonsquamous NSCLC. Datopotamab deruxtecan (Dato‐DXd) is a trophoblast cell‐surface antigen‐2 (TROP2)‐directed antibody‐drug conjugate (ADC) that has demonstrated clinical activity in patients with NSCLC who have received prior ...
Ying Hong, Anna M. Mc Laughlin, Yuzhuo Pan, Sofia Friberg Hietala, Sophie Peigné, Michael Chargualaf, Zoey Tang, Diansong Zhou, Naoyuki Tajima, Malaz Abutarif, Tushar Garimella   +10 more
wiley   +1 more source

SYNTHETIC VACCINES - SYNTHESIS OF A DIMERIC TN ANTIGEN-LIPOPEPTIDE CONJUGATE THAT ELICITS IMMUNE-RESPONSES AGAINST TN-EXPRESSING GLYCOPROTEINS

, 1994
SYNTHETIC VACCINES - SYNTHESIS OF A DIMERIC TN ANTIGEN-LIPOPEPTIDE CONJUGATE THAT ELICITS IMMUNE-RESPONSES AGAINST TN-EXPRESSING ...
T TOYOKUNI (21031199), D BOIVIN (21031214), AK SINGHAL (21031217), SP CAI (21031211), Belinda Dean (13066290), S HAKOMORI (21031202)   +5 more
core  

Tn Antigen Mimics by Ring-Opening of Chiral Cyclic Sulfamidates with Carbohydrate C1-S- and C1-O-Nucleophiles [PDF]

, 2018
Starting from commercially available (S)-isoserine and effectively accessible (S)-α-methylserine, enantiopure cyclic sulfamidates have been prepared as chiral building blocks for the synthesis of various S- and O-glycosylated amino acid derivatives ...
Oroz, P. [0000-0003-0854-5059], Gonzalo Jiménez-Osés, Corzana, F. [0000-0001-5597-8127], Peregrina, J.M. [0000-0003-3778-7065], Avenoza, A. [0000-0002-5465-3555], Busto, J.H. [0000-0003-4403-4790], García, I., Nuria Mazo, Pablo Tovillas, Paula Oroz, Jesús H. Busto, Jesús M. Peregrina, Iván García, Mazo, N. [0000-0001-6049-0871], Jiménez-Osés, G. [0000-0003-0105-4337], Tovillas, P., Alberto Avenoza, Francisco Corzana, Busto, J.H., Avenoza, A., Corzana, F., Jiménez-Osés, G., Peregrina, J.M., Mazo, N., Oroz, P.   +24 more
core   +1 more source

Goofy/123Cre lineage tracing differentiates olfactory and vomeronasal neurons from GnRH‐1 and terminal nerve neurons during neuronal migration and reveals additional olfactory placode‐derived cells in the brain

Developmental Dynamics, EarlyView.
Abstract The olfactory placode (OP) generates a broad array of chemosensory neurons in the nasal region, including olfactory sensory neurons, vomeronasal sensory neurons, neurons of the septal organ, and Grueneberg ganglion. During invagination, the OP also generates migratory neuronal populations, including gonadotropin‐releasing hormone‐1 (GnRH‐1 ...
Enrico Amato Jr., Mia V. Call, Noah M. LeFever, Mya Aviles‐Carlos, Nikki M. Dolphin, Paolo E. Forni   +5 more
wiley   +1 more source

PRDM16 is necessary for sensory neuronal development and differentiation in the trigeminal ganglion

Developmental Dynamics, EarlyView.
Abstract Background Cranial neural crest cells (cNCC) generate craniofacial cartilage, bone, and peripheral neurons and glia, and birth defects arise when the cartilage/neuronal/glial progenitors fail to differentiate. PRDM16 is a transcriptional regulator containing both zinc‐finger and SET domains, implicated in craniofacial development and orofacial
Fahmida Raha, Qiman Gao, Lomeli C. Shull, Kristin B. Artinger   +3 more
wiley   +1 more source

Maternal Tn Immunization Attenuates Hyperoxia-Induced Lung Injury in Neonatal Rats Through Suppression of Oxidative Stress and Inflammation

Frontiers in Immunology, 2019
Hyperoxia therapy is often required to treat newborns with respiratory disorders. Prolonged hyperoxia exposure increases oxidative stress and arrests alveolar development in newborn rats.
Chung-Ming Chen, Chung-Ming Chen, Jaulang Hwang, Hsiu-Chu Chou   +3 more
doaj   +1 more source

CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome

The Journal of Clinical Investigation, 2022
Chimeric antigen receptor (CAR) T cell expansion and persistence represent key factors to achieve complete responses and prevent relapses. These features are typical of early memory T cells, which can be highly enriched through optimized manufacturing ...
Silvia Arcangeli, Camilla Bove, Claudia Mezzanotte, Barbara Camisa, Laura Falcone, Francesco Manfredi, Eugenia Bezzecchi, Rita El Khoury, Rossana Norata, Francesca Sanvito, Maurilio Ponzoni, Beatrice Greco, Marta Angiola Moresco, Matteo G. Carrabba, Fabio Ciceri, Chiara Bonini, Attilio Bondanza, Monica Casucci   +17 more
doaj   +1 more source