Results 201 to 210 of about 683,828 (283)

Clinical Practice Profiles Among Japanese General Medicine Physicians in Treating Adult Patients With Periodic Fever Associated With Autoinflammatory Diseases: A Nationwide Cross‐Sectional Survey

Journal of General and Family Medicine, Volume 27, Issue 6, November 2026.
ABSTRACT Background In Japan, general medicine physicians (GMPs) may treat adult patients who have periodic fever associated with autoinflammatory diseases. However, little is known about the status of practice among GMPs in treating these patients.
Noriyuki Takahashi, Eisuke Inage, Seiji Tanaka, Yusuke Hiyoshi, Keishiro Hojo, Shingo Niimi, Yukiko Hidaka, Seira Hattori, Mitsuyasu Ohta, Saori Kadowaki, Mayuka Shiraki, Kazushi Izawa, Eitaro Hiejima, Shuichi Ito, Hidenori Ohnishi, Hiroaki Ida, Takahiro Yasumi, Ryuta Nishikomori   +17 more
wiley   +1 more source

Liquid Biopsy: Past, Present, and Future

MedComm, Volume 7, Issue 11, November 2026.
Liquid biopsy has expanded from cancer genotyping to a broader strategy for probing both oncologic and nononcologic conditions through circulating analytes and multilayer molecular readouts. This review traces the field's past, present, and future—summarizing where liquid biopsy is most actionable today, why performance varies across contexts, and ...
Jiachen Liu, Dianjie Zeng, Keran Zhao, Yuxi Wang, Huijie Hu, Fei Deng, Yinhuai Wang, Liya Sun, Liangmin Fu   +8 more
wiley   +1 more source

Multi‐Omics Insights Into Circulating T‐Cell Metabolic Reprogramming and Treg Dysfunction in Moyamoya Disease

MedComm, Volume 7, Issue 11, November 2026.
The comprehensive study design is illustrated. A multi‐omics approach was used to characterize T‐cell metabolic alterations in MMD. By integrating mass cytometry (CyTOF), single‐cell RNA sequencing (scRNA‐seq), bulk RNA‐seq, metabolomics, and flow cytometry, we aimed to elucidate metabolic reprogramming in circulating T cells and Treg dysfunction in ...
Zhiyao Zheng, Qiheng He, Xinyu Ma, Bojian Zhang, Junsheng Li, Chenglong Liu, Siqi Mou, Wei Sun, Xiangjun Shi, Wenjing Wang, Dong Zhang, Peicong Ge, Jizong Zhao   +12 more
wiley   +1 more source

A Pan‐Hepatic T‐Cell Atlas Identifies Disease‐Specific Immune Dysfunction and Therapeutic Targets for Immunotherapy

MedComm, Volume 7, Issue 11, November 2026.
A Pan‐HEpatic single‐cell Atlas of T cells (Pheat) was constructed covering chronic hepatitis, cirrhosis, hepatocellular carcinoma (HCC), and healthy controls. CD8+ exhausted T cells (Tex) and CD4+ regulatory T cells (Treg) were delineated profound through decoding molecular and cellular variance, immune checkpoint networks, pathway analysis, and drug ...
Si‐Yuan Chen, You‐Yuan Wang, Shuang‐Nan Zhou, Ming‐Ju Zhou, Xia Li, Wei‐Zhe Li, Meng‐Meng Zhu, Yu‐Xuan Yang, Ying Sun, Peiyao Fan, Jing Li, Xing Fan, Ruonan Xu, Yan‐Mei Jiao, Jin‐Wen Song, Cheng Zhen, Ming Shi, Chao Zhang, Fu‐Sheng Wang   +18 more
wiley   +1 more source

Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing tn antigen. [PDF]

J Biol Chem, 2012
Mi R, Song L, Wang Y, Ding X, Zeng J, Lehoux S, Aryal RP, Wang J, Crew VK, van Die I, Chapman AB, Cummings RD, Ju T.   +12 more
europepmc   +1 more source

Site‐specific O‐glycans influence lacritin structure and multimerization in tears

Protein Science, Volume 35, Issue 11, November 2026.
Abstract Lacritin is an abundantly expressed glycoprotein in tear fluid and plays key roles in immune response, tear secretion, and bacterial killing. These biological functions are tightly regulated through several biochemical mechanisms including multimerization, proteolysis, and alternative splicing, especially within its C‐terminal domain.
Vincent Chang, Ryan J. Chen, Isaac Lian, Madilynn Hamilton, Keira E. Mahoney, Jeff Romano, Gordon Laurie, Stacy A. Malaker   +7 more
wiley   +1 more source

Transposons as Tools for Future Genome Engineering in Yeasts and Filamentous Fungi

Yeast, Volume 43, Issue 6, Page 276-289, November 2026.
Applications of transposon‐based tools for genome engineering in fungi include transposon‐mediated mutagenesis and targeted genomic integration. ABSTRACT Transposons are fundamental genetic elements that have profoundly shaped the architecture of eukaryotic genomes.
Bingyin Peng, Masahiro Tominaga, Chengqiang Wang, Robert E. Speight, Jun Ishii   +4 more
wiley   +1 more source

AI‐based anatomical recognition for bladder neck dissection in robot‐assisted radical prostatectomy

BJU International, Volume 138, Issue 5, Page 852-859, November 2026.
Objective To develop an artificial intelligence (AI) system for anatomical recognition that can automatically identify key anatomical structures during bladder neck dissection in robot‐assisted radical prostatectomy (RARP), a critical yet technically demanding step.
Shinnosuke Fujiwara, Keishiro Fukumoto, Masashi Takeuchi, Yuichiro Konnai, Yota Yasumizu, Nobuyuki Tanaka, Toshikazu Takeda, Kazuhiro Matsumoto, Takeo Kosaka, Hirofumi Kawakubo, Masaru Ishida, Yuko Kitagawa, Mototsugu Oya   +12 more
wiley   +1 more source

Transplantation of Hepatitis B Surface Antigen Positive or Viremic Kidneys: A Systematic Review and Meta‐Analysis

Clinical Transplantation, Volume 40, Issue 11, November 2026.
ABSTRACT Purpose This systematic review and meta‐analysis examines the evidence related to the use of HBV positive kidneys into non‐viremic kidney transplant recipients (KTRs). Methods We searched PubMed and Embase through November 2025 and identified studies of recipients of hepatitis B surface antigen positive (HBsAg+) or viremic kidneys.
Dhruv Ahuja, Beatrice P. Concepcion, Yuhong Yuan, Rachel Forbes, James L. Rogers, Helen S. Te, Yvonne El Kassis   +6 more
wiley   +1 more source

Application of Mechanistic Modeling to Support Dose‐Relevant Decision Making for CAR‐T Cell Therapy in Oncology: A Systematic Scoping Review

Clinical and Translational Science, Volume 19, Issue 11, November 2026.
ABSTRACT CAR‐T therapy has improved outcomes in selected relapsed or refractory hematologic malignancies. However, rational dose‐relevant decision application remains challenging because the administered (nominal) cell dose does not reliably predict in vivo exposure, toxicity, or clinical response.
Dolapo Odujinrin, Graham McClelland
wiley   +1 more source