Results 191 to 200 of about 683,828 (283)
Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy
Advanced Science, Volume 13, Issue 61, 3 November 2026.By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng +16 more
wiley +1 more source
An Innervated Human Skin Equivalent that Electrically Encodes Mechanical and Thermal Stimuli
Advanced Science, Volume 13, Issue 61, 3 November 2026.An innervated human skin equivalent is integrated with high‐density microelectrode arrays to reveal how engineered free nerve ending–like structures translate touch and temperature into electrical codes. Mechanical indentation and thermal stimulation engage the engineered somatosensory circuitry and evoke distinct firing and waveform signatures ...
Daniele Bellantoni +6 more
wiley +1 more source
Specific Identification of Glycoproteins Bearing the Tn Antigen in Human Cells. [PDF]
Angew Chem Int Ed Engl, 2017 Zheng J, Xiao H, Wu R.
europepmc +1 more source
A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control
Advanced Science, Volume 13, Issue 61, 3 November 2026.Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias +23 more
wiley +1 more source
Tn antigen promotes human colorectal cancer metastasis via H-Ras mediated epithelial-mesenchymal transition activation. [PDF]
J Cell Mol Med, 2019 Liu Z +10 more
europepmc +1 more source
Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1379-1388, November 2026.Dengue virus (DENV) infection is a significant global health threat. Mosnodenvir (JNJ‐64281802) is a pan‐serotype small molecule antiviral blocking DENV replication. A Phase IIa study (NCT05048875) evaluated the antiviral activity, safety, and pharmacokinetics of mosnodenvir as prophylaxis against DENV‐3 in a controlled human infection model (CHIM).
Nele Goeyvaerts +8 more
wiley +1 more source
An Orthotopic Xenograft Model for Preclinical Evaluation of CAR T Cell Therapy in Glioblastoma
Current Protocols, Volume 6, Issue 11, November 2026.Abstract Glioblastoma (GBM) is the most lethal primary brain tumor in adults, and despite intensive research efforts, effective therapeutic breakthroughs remain elusive. Consequently, the standard of care has remained largely unchanged for nearly 30 years, underscoring the need for robust preclinical models to evaluate experimental therapies.
Julian Hübner +6 more
wiley +1 more source
Potato Protein Peptides as a Serum‐Reducing Supplement for MDCK Cell Culture Medium
Food Science &Nutrition, Volume 14, Issue 11, November 2026.Flavorzyme hydrolysis was used to prepare PPPs. Supplementation of the medium containing 5% NBS with 1 g/L PPPs supported MDCK cell proliferation and colony‐forming capacity during serial passaging; growth at passage 9 was comparable to that of the 10% NBS control.
Dandan Gao +9 more
wiley +1 more source