Results 21 to 30 of about 683,828 (283)

Detection of Tn-antigen in breast and prostate cancer models by VVL-labeled red dye-doped nanoparticles. [PDF]

Nanomedicine (Lond)
Aim: Fluorescence detection of breast and prostate cancer cells expressing Tn-antigen, a tumor marker, with Vicia villosa lectin (VVL)-labeled nanoparticles. Materials & methods: Breast and prostate cancer cells engineered to express high levels of Tn-
Verhassel A, Kimani M, Gidwani K, Sandholm J, Gawlitza K, Rurack K, Härkönen P.   +6 more
europepmc   +2 more sources

Thermoneutrality Alters Gastrointestinal Antigen Passage Patterning and Predisposes to Oral Antigen Sensitization in Mice

Frontiers in Immunology, 2021
Food allergy is an emerging epidemic, and the underlying mechanisms are not well defined partly due to the lack of robust adjuvant free experimental models of dietary antigen sensitization.
Taeko K. Noah, Taeko K. Noah, Jee-Boong Lee, Christopher A. Brown, Amnah Yamani, Amnah Yamani, Sunil Tomar, Sunil Tomar, Varsha Ganesan, Varsha Ganesan, Rodney D. Newberry, Gary B. Huffnagle, Gary B. Huffnagle, Senad Divanovic, Senad Divanovic, Senad Divanovic, Simon P. Hogan, Simon P. Hogan   +17 more
doaj   +1 more source

Preclinical Studies of Granulysin-Based Anti-MUC1-Tn Immunotoxins as a New Antitumoral Treatment

Biomedicines, 2022
Two granulysin (GRNLY) based immunotoxins were generated, one containing the scFv of the SM3 mAb (SM3GRNLY) and the other the scFv of the AR20.5 mAb (AR20.5GRNLY). These mAb recognize different amino acid sequences of aberrantly O-glycosylated MUC1, also
Patricia Guerrero-Ochoa, Raquel Ibáñez-Pérez, Germán Berbegal-Pinilla, Diederich Aguilar, Isabel Marzo, Francisco Corzana, Martha Minjárez-Sáenz, Javier Macías-León, Blanca Conde, Javier Raso, Ramón Hurtado-Guerrero, Alberto Anel   +11 more
doaj   +1 more source

Primary breast cancer tumours contain high amounts of IgA1 immunoglobulin: an immunohistochemical analysis of a possible carrier of the tumour-associated Tn antigen. [PDF]

PLoS ONE, 2013
The Tn antigen (GalNAc alpha-O-Ser/Thr) as defined by the binding of the lectin, helix pomatia agglutinin (HPA) or anti-Tn monoclonal antibodies, is known to be exposed in a majority of cancers, and it has also been shown to correlate positively with the
Charlotte Welinder, Bo Baldetorp, Ola Blixt, Dorthe Grabau, Bo Jansson   +4 more
doaj   +1 more source

Native Tn only becomes an antigen when its protein no longer matches the protein of natural innate anti-Tn-reactive IgM

, 2023
   In view of the simultaneous formation of Helix pomatia-specific, Tn/serologically A-like glycolipids with germline-encoded anti-Helix pomatia-, Tn/A cross- reactive  IgM in the ovary of a healthy and fertile mouse, it is suggested that the mammalian ...
Peter Arend (560469)
core   +1 more source

Expression of Tn, sialosyl-Tn and T antigens in human foetal large intestine

European Journal of Histochemistry, 2009
Tn, sialosyl-Tn and T antigens are simple mucintype carbohydrate antigens that may be expressed in human neoplasies due to alteration of the glycoprotein biosynthetic pathway.
M Grosso, E Vitarelli, G Giuffrè, G Tuccari, G Barresi   +4 more
doaj   +3 more sources

Carbohydrate receptor-mediated gene transfer to human T leukaemic cells [PDF]

, 1994
The mucin-type carbohydrate Tn cryptantigen (GalNAcα1-O-Ser/Thr, where GalNAc is N-acetyl-D-galactosamine) is expressed in many carcinomas, in haemopoietic disorders including the Tn syndrome, and on human immunodeficiency virus (HIV) coat glycoproteins,
Berger, Eric G., Berger, Eric G, Mechtler, Karl, Rusconi, Sandro, Wagner, Ernst, Birnstiel, Max L., Cotten, Matt, Clausen, Erik, Dinter, André, Thurnher, Martin, Berger, Erik G., Clausen, Henrik, Birnstiel, Max L, Wagner E, Cotten M, Clausen H, Mechtler K, Rusconi S, Birnstiel ML, Thurnher M, Berger EG, Dinter A   +21 more
core   +1 more source

Side population cells derived from hUCMSCs and hPMSCs could inhibit the malignant behaviors of Tn+ colorectal cancer cells from modifying their O-glycosylation status

Stem Cell Research & Therapy, 2023
Background Cosmc (C1GalT1C1) mutation could cause aberrant O-glycosylation and result in expression of Tn antigen on the surface of tumor cells (Tn+ cells), which is associated with the metastasis and prognosis of cancer progression.
Wen Hu, Ruisong Ding, Mengyang Wang, Panpan Huang, Xia Wei, Xingyou Hu, Tao Hu   +6 more
doaj   +1 more source

Effect of anticancer therapy on Tn antigen exposure on the leucocyte membranes in patients with leukemia

Regulatory Mechanisms in Biosystems, 2014
Tn-antigen (Thomsen-nouvelle antigen) is tumor-associated carbohydrate antigen with only one GalNAc residue attached to serine or threonine of polypeptide chain.
G. S. Maslak
doaj   +1 more source

Expression of tumor-associated antigens in breast cancer subtypes

Breast, 2020
Objectives: Tumor-associated antigens (TAAs) are frequently overexpressed in several cancer types. The aim of this study was to investigate the expression of TAAs in breast cancer.
Giuseppe Curigliano, Vincenzo Bagnardi, Mariacristina Ghioni, Jamila Louahed, Vincent Brichard, Frederic F. Lehmann, Antonio Marra, Dario Trapani, Carmen Criscitiello, Giuseppe Viale   +9 more
doaj   +1 more source