Results 31 to 40 of about 683,828 (283)
Oxygen by Carbon Replacement at the Glycosidic Linkage Modulates the Sugar Conformation in Tn Antigen Mimics [PDF]
, 2018 N-Acetylgalactosamine (GalNAc) α-O-linked to l-threonine (Thr) (Tn antigen) and several mimics of this Tn antigen have been synthesized to explore the impact of the underlying amino acid in the presentation mode of the carbohydrate moiety. The structural
Alberto Avenoza (1470724) +47 more
core +1 more source
Frontiers in Immunology, 2023 Dendritic cell (DC)-maturation stimuli determine the potency of these antigen-presenting cells and, therefore, the quality of the T-cell response. Here we describe that the maturation of DCs via TriMix mRNA, encoding CD40 ligand, a constitutively active ...
Wout de Mey +10 more
doaj +1 more source
Synthesis of Tn Antigen Mimetics and Their Incorporation into the MUC1 Glycoprotein Sequence [PDF]
, 2022 Cancer is a disease with one of the highest mortality rates in the first world countries and its treatment today is still invasive and often ineffective.
J. M. Peregrina [0000-0003-3778-7065] +4 more
core
Emerging Roles of the Unique Molecular Chaperone Cosmc in the Regulation of Health and Disease
Biomolecules, 2022 The core-1 β1-3galactosyltransferase-specific chaperone 1 (Cosmc) is a unique molecular chaperone of core-1 β1-3galactosyltransferase(C1GALT1), which typically functions inside the endoplasmic reticulum (ER).
Ting Xiang +4 more
doaj +1 more source
Expression of the Tn antigen on erythroid cells from a patient with Tn syndrome [PDF]
Japanese journal of human genetics, 1992 In order to examine expression of the Tn antigen on erythroid cells from a patient with Tn syndrome, we applied a selective two phase liquid culture system for human erythroid progenitors in peripheral blood. The cells were analyzed with flow cytometry employing an anti-Tn antibody and a lectin of Vicia villosa which recognizes only the Tn determinant.
Y, Kamitani +3 more
openaire +2 more sources
Cancer Management and Research, 2022 Xu F, Wang D, Cui J, Li J, Jiang H. Cancer Manag Res. 2020;12:1017–1027. At the authors request, the Editor and Publisher of Cancer Management and Research wish to retract the published article.
Xu F, Wang D, Cui J, Li J, Jiang H
doaj
Acta Pharmaceutica Sinica B, 2022 We present a new strategy for self-adjuvanting vaccine development that has different types of covalently-linked immunostimulants as the carrier molecule.
Deying Yang +8 more
doaj +1 more source
Different expression of Tn and sialyl-Tn antigens between normal and diseased human gastric epithelial cells. [PDF]
, 1998 Thomsen-Friedenreich antigen (T antigen) has been supposed to be a cancer-specific carbohydrate antigen. We have previously shown that one third of the Japanese population normally expressed T antigen in gastric surface epithelia and the other two thirds
Tsuji, Takao +4 more
core +1 more source
, 2021 Alterations in glycosylation cause the emergence of tumor-associated carbohydrate antigens (TACAs) during tumorigenesis. Truncation of O-glycans reveals the Thomsen nouveau (Tn) antigen, an N-acetylgalactosamine (GalNAc) frequently attached to serine or ...
Maxime Henry (4376956) +21 more
core +1 more source
Efficient and Reproducible Synthesis of an Fmoc-protected Tn Antigen [PDF]
, 2021 The total synthesis of the Thomsen-nouveau (Tn) antigen, a tumour-associated O-linked mucin glycopeptide, was achieved through a concise route. The key glycosylation step proved challenging to reproduce from the literature precedents and was most ...
John F., Trant +4 more
core +1 more source