Results 221 to 230 of about 80,718 (256)

Expression of Tn, sialosyl Tn, and T antigens in human pancreas

Gastroenterology, 1991
Carbohydrate antigens representing some of the initial steps in mucin O-linked glycosylation were examined in specimens of normal pancreas, chronic pancreatitis, and pancreatic adenocarcinoma. Tn antigen, recognized by Vicia villosa lectin, was expressed by all specimens of normal pancreas (acinar cells) and pancreatic cancers and all but one case of ...
S, Itzkowitz, T, Kjeldsen, A, Friera, S, Hakomori, U S, Yang, Y S, Kim   +5 more
openaire   +2 more sources

Tn‐activation with Acquired A‐like Antigen

Transfusion, 1972
The red blood cells of Mr. R. W., an 86‐year‐old type O patient with Proteus mirabilis wound infection, anemia, and thrombocytopenia were found to be polyagglutinable due to Tn‐activation, to be agglutinated by and to absorb anti‐A, and to have a reduced sialic acid level probably as a result of enzyme modification in vivo. The reaction with anti‐A was
H J, Berman, J, Smarto, C H, Issitt, P D, Issitt, W L, Marsh, L, Jensen   +5 more
openaire   +2 more sources

An Example of Polyagglutinability Due to the Tn Antigen

British Journal of Haematology, 1970
Summary. A case of atypical polyagglutinability due to the Tn antigen is described. The patient, although apparently healthy, has leucopenia and thrombocytopenia. Her cells presented the usual difficulties of polyagglutinable cells due to the presence of anti‐Tn in typing reagents whether of human or animal origin.
H H, Gunson, F, Stratton, G W, Mullard
openaire   +2 more sources

Rational design of a Tn antigen mimic

Chemical Communications, 2011
A novel Tn antigen mimic, in which the natural underlying amino acid has been replaced by the non-natural α-methylserine analogue, is reported. This derivative exhibits a similar affinity for a natural lectin as for the natural Tn and retains the bioactive conformation observed in the Tn-containing glycopeptides with anti-MUC1 antibodies.
Corzana, Francisco, Busto, Jesús H., Marcelo, Filipa, García de Luis, Marisa, Asensio, Juan Luis, Martín-Santamaría, Sonsoles, Sáenz, Yolanda, Torres, Carmen, Jiménez-Barbero, Jesús, Avenoza, Alberto, Peregrina, Jesús M.   +10 more
openaire   +3 more sources

A monoclonal antibody directed to Tn antigen

Biochemical and Biophysical Research Communications, 1990
A murine monoclonal antibody, MLS 128, that was assigned to an anti-Tn antibody has been established by immunizing mice with human colonic cancer cells (LS 180). MLS 128 bound to mucin glycopeptides from LS 180 cells and their asialo forms to the same extent as well as to ovine submaxillary mucin (OSM) and asialo OSM.
Y, Numata, H, Nakada, S, Fukui, H, Kitagawa, K, Ozaki, M, Inoue, T, Kawasaki, I, Funakoshi, I, Yamashina   +8 more
openaire   +2 more sources

Expression of sialyl‐Tn, Tn and T antigens in primary liver cancer

Pathology International, 1999
Sialyl‐Tn, Tn and T antigens are caused by aberrant or incomplete glycosylation of apomucins and are related to the aggressiveness of malignant neoplasms. Using 41 liver samples from patients with cholangiocarcinoma (including four with cirrhosis), 21 with combined hepatocellular– cholangiocellular carcinoma and 17 with hepatocellular carcinoma, the ...
M, Sasaki, T, Yamato, Y, Nakanuma
openaire   +2 more sources

Enzymatic synthesis of the Tn antigen

Journal of Molecular Catalysis B: Enzymatic, 2007
The enzymatic synthesis of the Tn antigen (GalNAc--O-Ser), a glyco-aminoacid of great biological importance, is reported. The reaction was promoted by commercial -N-acetylgalactosaminidase from Acremonium sp., using p-nitrophenyl--N-acetylgalactosamine as the donor. The kinetics were monitored by capillary electrophoresis and LC–UV-MS.
COSLOVI, ANNA, Cristiana Campa, FLAMIGNI, ANNA, Marco Rossi, VETERE, AMEDEO, Fulvio Uggeri, PAOLETTI, SERGIO   +6 more
openaire   +2 more sources

Tumor‐associated antigens: Tn antigen, sTn antigen, and T antigen

HLA, 2016
AbstractGlycosylation is one of the major posttranslational modifications of proteins. N‐glycosylation (Asn‐linked) and O‐glycosylation (Ser/Thr‐linked) are the two main forms. Abnormal O‐glycosylation is frequently observed on the surface of tumor cells, and is associated with an adverse outcome and poor prognosis in patients with cancer.
C, Fu, H, Zhao, Y, Wang, H, Cai, Y, Xiao, Y, Zeng, H, Chen   +6 more
openaire   +2 more sources

Expression of the Tn antigen in myelodysplasia, lymphoma, and leukemia

Transfusion, 1992
Expression of the normally cryptic blood group antigen Tn has occasionally been reported in hematologic disease, but the true frequency of this change is not known. A mouse monoclonal antibody (FBT3) and immunohistochemistry were used to examine expression of the Tn antigen.
D J, Roxby, M B, Pfeiffer, A A, Morley, M A, Kirkland   +3 more
openaire   +2 more sources

Detection of Tn, sialosyl-Tn and T antigens in hereditary nonpolyposis colorectal cancer

Virchows Archiv, 1996
The simple mucin-type carbohydrate antigens Tn, sialosyl-Tn, T and the 'cryptic' sialylated variant of the last represent the mucin core oligosaccharide structures that are produced in the initial steps of the mucin biosynthetic pathway. Utilizing monoclonal antibodies anti-Tn antigen (HB-Tn1), anti-sialosyl-Tn antigen (HB-STn1), anti-T antigen (HB-T1)
GIUFFRE', Giuseppe, VITARELLI E, TUCCARI, Giovanni, DELEON MP, BARRESI, Gaetano   +4 more
openaire   +3 more sources