Passenger variants as pan‐clonal markers of pediatric AML: Implications for molecular MRD
Abstract A streamlined, sensitive, and universal molecular method for MRD detection in pediatric AML remains an unmet clinical need. Here, we propose a novel approach based on tracking somatic non‐coding passenger variants. Using whole‐genome sequencing (WGS) of diagnostic bone marrow DNA, we identify patient‐specific somatic passenger variants, which ...
Ruth Shiloh +20 more
wiley +1 more source
ABSTRACT Background and Aims Solid tumors emerge from uncontrolled cell division and interactions with neighboring cells that influence their growth and resistance to therapy. Anti‐cancer drugs are developed to disrupt these processes, but they often damage healthy cells, making treatment difficult to manage safely and effectively. As the global cancer
Mohsin Kamran +3 more
wiley +1 more source
Deletion of Core 1 β3GalT-specific molecular chaperone (Cosmc) in murine intestinal epithelia leads to major alterations in glycocalyx and tumorigenesis. [PDF]
Ju T +11 more
europepmc +1 more source
DC-CD4 bispecific tolerogenic nanovesicles induce antigen-specific regulatory T cells and ameliorate collagen-induced arthritis in mice. [PDF]
Zhao L +9 more
europepmc +1 more source
α-Galactosylceramide-expanded virtual memory CD8<sup>+</sup> T cells confer protection against a broad range of pathogens. [PDF]
Xie JX +6 more
europepmc +1 more source
Process Safety Assessment of the Iron-Catalyzed 1,2-<i>cis</i>-Selective Glycal Aminoglycosylation. [PDF]
Zhang D +5 more
europepmc +1 more source
Soluble IL-2 receptor and memory Treg profiles differentiate early rheumatoid arthritis from undifferentiated arthritis at initial presentation. [PDF]
Zi X, Shi Y, Zhao Y, Gao C, Wang C.
europepmc +1 more source

