Results 1 to 10 of about 62 (59)

Emerging Roles of the Unique Molecular Chaperone Cosmc in the Regulation of Health and Disease

Biomolecules, 2022
The core-1 β1-3galactosyltransferase-specific chaperone 1 (Cosmc) is a unique molecular chaperone of core-1 β1-3galactosyltransferase(C1GALT1), which typically functions inside the endoplasmic reticulum (ER).
Hailong Xie
exaly   +3 more sources

COSMC mutations reduce T-synthase activity in advanced Alzheimer's disease

Alzheimer's and Dementia: Translational Research and Clinical Interventions, 2020
Introduction Mutations in brain tissues that cumulate with age may contribute to Alzheimer's disease (AD). Abnormal glycoprotein and Tn antigen expression have been demonstrated in AD. We identified C1GALT1C1/COSMC mutations in AD and age‐matched normals
Seema Gollamudi, Rukmani Lekhraj, Shirin Lalezari, Parviz Lalezari   +3 more
exaly   +2 more sources

COSMC-Regulated O-Glycosylation: A Bioinformatics-Driven Biomarker Identification for Stratifying Glioblastoma Stem Cell Subtypes

Kinases and Phosphatases
Glioblastoma stem cells (GSCs) are key drivers of relapse, metastasis, and therapy resistance in glioblastoma due to their adaptability and diversity, which make them challenging to target effectively.
Rada Amin
exaly   +3 more sources

COSMC is overexpressed in proliferating infantile hemangioma and enhances endothelial cell growth via VEGFR2. [PDF]

PLoS ONE, 2013
Infantile hemangiomas are localized lesions comprised primarily of aberrant endothelial cells. COSMC plays a crucial role in blood vessel formation and is characterized as a molecular chaperone of T-synthase which catalyzes the synthesis of T antigen ...
Jian Lee, Chia-Hua Chen, Ya-Hsin Chen, Miao-Juei Huang, John Huang, Ji-Shiang Hung, Ming-Ting Chen, Min-Chuan Huang   +7 more
doaj   +1 more source

Biochemical characterization of functional domains of the chaperone Cosmc. [PDF]

PLoS ONE, 2017
Cosmc is an endoplasmic reticulum chaperone necessary for normal protein O-GalNAc glycosylation through regulation of T-synthase, its single client. Loss-of-function of Cosmc results in expression of the Tn antigen, which is associated with multiple ...
Melinda S Hanes, Kelley W Moremen, Richard D Cummings   +2 more
doaj   +1 more source

DNA methylation in Cosmc promoter region and aberrantly glycosylated IgA1 associated with pediatric IgA nephropathy.

PLoS ONE, 2015
IgA nephropathy (IgAN) is one of the most common glomerular diseases leading to end-stage renal failure. Elevation of aberrantly glycosylated IgA1 is a key feature of it.
Qiang Sun, Jianqian Zhang, Nan Zhou, Xiaorong Liu, Ying Shen   +4 more
doaj   +1 more source

Side population cells derived from hUCMSCs and hPMSCs could inhibit the malignant behaviors of Tn+ colorectal cancer cells from modifying their O-glycosylation status

Stem Cell Research & Therapy, 2023
Background Cosmc (C1GalT1C1) mutation could cause aberrant O-glycosylation and result in expression of Tn antigen on the surface of tumor cells (Tn+ cells), which is associated with the metastasis and prognosis of cancer progression.
Wen Hu, Ruisong Ding, Mengyang Wang, Panpan Huang, Xia Wei, Xingyou Hu, Tao Hu   +6 more
doaj   +1 more source

Development and testing of INSPIRE themes Addresses (AD) and Administrative Units (AU) managed by COSMC

Geoinformatics FCE CTU, 2013
Main content of this article is to describe implementing INSPIRE themes Addresses and Administrative Units in Czech Republic. Themes were implemented by Czech Office for Surveying, Mapping and Cadastre.
Michal Med, Petr Souček
doaj   +1 more source

Glycan elongation beyond the mucin associated Tn antigen protects tumor cells from immune-mediated killing. [PDF]

PLoS ONE, 2013
Membrane bound mucins are up-regulated and aberrantly glycosylated during malignant transformation in many cancer cells. This results in a negatively charged glycoprotein coat which may protect cancer cells from immune surveillance. However, only limited
Caroline B Madsen, Kirstine Lavrsen, Catharina Steentoft, Malene B Vester-Christensen, Henrik Clausen, Hans H Wandall, Anders Elm Pedersen   +6 more
doaj   +1 more source

Implementing INSPIRE for the Czech

Geoinformatics FCE CTU, 2012
The article is dedicated to the topic of the implementation of INSPIRE directive within the Information System of the Czech Cadastre of Real Estates. The procedure of implementation of the INSPIRE directive for cadastral related themes, which started in ...
Jiří Poláček, Petr Souček
doaj   +1 more source