Results 11 to 20 of about 1,085 (173)

Cosmc controls B cell homing [PDF]

Nature Communications, 2020
Migration and homing of B cells to lymph nodes are important for B cell functions, but their regulation is poorly understood. Here, the authors show that B cell-specific deletion of Cosmc results in decreased protein O-glycosylation, loss of B cell ...
Junwei Zeng, Mahmoud Eljalby, Rajindra P. Aryal, Sylvain Lehoux, Kathrin Stavenhagen, Matthew R. Kudelka, Yingchun Wang, Jianmei Wang, Tongzhong Ju, Ulrich H. von Andrian, Richard D. Cummings   +10 more
doaj   +4 more sources

Bioinformatic Analysis of C1GALT1 in Cancer: Insights Into Prognosis, Metastasis and Therapeutic Potential [PDF]

Cancer Reports
Background This study evaluates the expression, regulation, and clinical relevance of C1GALT1, a key enzyme in mucin‐type O‐glycosylation, across a broad spectrum of human cancers.
Ecem Kalemoglu, Ayse Caner
doaj   +3 more sources

C1GALT1C1 ‐Associated Mosaic Disorder of Glycosylation in a Female [PDF]

J Inherit Metab Dis
Cosmc, encoded by the X‐linked C1GALT1C1, is a molecular chaperone in the endoplasmic reticulum and a master regulator of O‐glycosylation of mammalian glycoproteins.
Cummings, Richard D., Seaver, Laurie H, Heimburg‐Molinaro, Jamie, Aryal, Rajindra P, Ramanujan, Aditya, Erger, Florian, Seaver, Laurie H., Bucci, Camille, Beck, Bodo B., Beck, Bodo B, Cummings, Richard D, Cummings, Sandra F., Cummings, Sandra F, Heimburg-Molinaro, Jamie, Aryal, Rajindra P., Neckelmann, Christian   +15 more
core   +3 more sources

Cosmc Deficiency Causes Spontaneous Autoimmunity by Breaking B Cell Tolerance [PDF]

Science Advances, 2021
Factors regulating the induction and development of B cell–mediated autoimmunity are not well understood. Here, we report that targeted deletion in murine B cells of X-linked Cosmc, encoding the chaperone required for expression of core 1 O-glycans ...
Liu, Renyan, Cummings, Richard D., Li, Hao, Stavenhagen, Kathrin, Wang, Xiaohui, Wang, Yingchun, Chen, Jiaxuan, Matsumoto, Yasuyuki, Wang, Jianmei, Ju, Tongzhong, Zeng, Junwei, Luo, Chi, Aryal, Rajindra P.   +12 more
core   +5 more sources

Protein O-Glycosylation Shapes Lymphatic Endothelia and Lymph Node Macrophage Populations. [PDF]

FASEB J
To study the functional roles of O‐glycans on lymphatic endothelia, we deleted Cosmc, the chaperone required for core‐1 O‐glycan synthesis. Loss of core‐1 O‐glycans entailed major changes in glycoprotein composition of lymphatic endothelial cells (LEC), including reduced podoplanin (Pdpn), CD44, and Lyve‐1, and increased ICAM‐1; reduced CD44 was caused
Frey J, Ratter A, Brigger F, Cielen L, Kunz P, Tulin E, Mikos K, Dieterich L, D'Addio M, Halin C, Cummings RD, Otto VI.   +11 more
europepmc   +2 more sources

LncSLED1 inhibits monosodium urate-induced macrophage inflammation by promoting Cosmc methylation to upregulate CA72-4 [PDF]

Central European Journal of Immunology
Introduction The core event of gout is intensified macrophage inflammation. Our preliminary research found that carbohydrate antigen 72-4 (CA72-4) secreted by monosodium urate (MSU)-induced human synovial cells (HFLS) could upregulate transforming growth
Ning Ren, Xiaojie Qu, Zhenzhen Wang, Xiaoning Zhang, Honglei Hu, Xueshan Bai   +5 more
doaj   +2 more sources

Performance Testing of Download Services of COSMC

Geoinformatics FCE CTU, 2013
The paper presents results of performance tests of download services of Czech Office of Surveying, Mapping and Cadastre according to INSPIRE  requirements. Methodology of testing is explained, including monitoring performance  of reference servers.
Jiří Horák, Jan Růžička, Jiří Ardielli   +2 more
doaj   +3 more sources

Cosmc loss induces truncated O-glycosylation and accelerates Kras-driven pancreatic carcinogenesis [PDF]

Neoplasia: An International Journal for Oncology Research
Aberrant mucin-type O-glycosylation is a common feature of pancreatic ductal adenocarcinoma (PDAC), yet its functional contribution to pancreatic tumorigenesis remains incompletely defined.
Baris Mercanoglu, Nina Schraps, Anastasios D. Giannou, Jingxuan Zhou, Simon Kind, Maya Reinecke, Karl-Frederick Karstens, Benjamin Dreyer, Sönke Harder, Siwen Zhang, Eleftherios D. Papazoglou, Cenap Güngör, Nathaniel Melling, Hartmut Schlüter, Christoph Wagener, Maximilian Bockhorn, Thilo Hackert, Gerrit Wolters-Eisfeld   +17 more
doaj   +2 more sources

IgM promotes antitumor immunity to a Tn-expressing solid tumor [PDF]

Journal for ImmunoTherapy of Cancer
Background Altered O-glycosylation is a hallmark of many adenocarcinomas and is often characterized by expression of the Tn antigen. However, the role of B cells in protection against Tn-expressing solid tumors remains poorly understood.Methods We ...
Hope L Nzuki, Jamie E Jennings-Gee, Michaela Trivette, Timothy H Mosher, Alexis E Adams-Sims, Abigail A Hegarty, Karen M Haas   +6 more
doaj   +2 more sources

Differential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers [PDF]

BMC Cancer, 2018
Background The Tn neoantigen (GalNAcα1-O-Ser/Thr) is an O-glycan expressed in various types of human cancers. Studies in several Tn-expressing cancer cell lines and pancreatic tumors have identified loss of Cosmc expression caused by either mutations or ...
Xiaodong Sun, Tongzhong Ju, Richard D. Cummings   +2 more
doaj   +3 more sources