Results 1 to 10 of about 1,300 (102)

Bioinformatic Analysis of C1GALT1 in Cancer: Insights Into Prognosis, Metastasis and Therapeutic Potential [PDF]

Cancer Reports
Background This study evaluates the expression, regulation, and clinical relevance of C1GALT1, a key enzyme in mucin‐type O‐glycosylation, across a broad spectrum of human cancers.
Ayşe Caner, Ecem Kalemoğlu
exaly   +3 more sources

EGFR TKIs suppress MUC1 glycosylation through the PI3K/AKT/SP1/C1GALT1 pathway to enhance TnMUC1 CAR-T efficacy in EGFR-mutant NSCLC [PDF]

Cell Reports Medicine
Summary: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are the standard first-line treatment for EGFR-mutant cancer (non-small cell lung cancer [NSCLC]), achieving an objective response rate (ORR) of approximately 60%–70 ...
Herui Yao, Yunfang Yu, Jianli Zhao
exaly   +4 more sources

C1GALT1, Negatively Regulated by miR-181d-5p, Promotes Tumor Progression via Upregulating RAC1 in Lung Adenocarcinoma

Frontiers in Cell and Developmental Biology, 2021
Glycosyltransferases are frequently dysregulated in lung cancer. Core 1 β 1, 3-galactosyltransferase 1 (C1GALT1), an enzyme highly expressed in various cancers, is correlated with tumor initiation and development.
Xinzhou Deng, Li Shen, Xiaoxia Dong
exaly   +3 more sources

Down-Regulation of C1GALT1 Enhances the Progression of Cholangiocarcinoma through Activation of AKT/ERK Signaling Pathways

Life, 2022
Alteration of mucin-type O-glycosylation is implicated in tumor progression and metastasis of cholangiocarcinoma (CCA). Core 1 β1-3 Galactosyltransferase (C1GALT1) is a primary enzyme that regulates the elongation of core 1-derived mucin-type O-glycans ...
Chavaboon Dechsukhum, Chutima Talabnin, Atit Silsirivanit   +2 more
exaly   +3 more sources

Structural basis for the synthesis of the core 1 structure by C1GalT1

Nature Communications, 2022
The glycosyltransferase C1GalT1 directs a key step in protein O-glycosylation important for the expression of the cancer-associated Tn and T antigens.
Filipa Marcelo, Ana Sofia Grosso, Francisco Corzana   +2 more
exaly   +2 more sources

CD276 immature glycosylation drives colorectal cancer aggressiveness and T cell mediated immune escape [PDF]

Cell Communication and Signaling
Background Colorectal cancer (CRC) progression is fuelled by immune evasion, yet the underlying molecular mechanisms remain to be fully characterized.
Janine Soares, Dylan Ferreira, Andreia Miranda, Martina Gonçalves, Marta Relvas-Santos, Andreia Brandão, Paula Paulo, Sofia Cotton, Rui Freitas, Mariana Magalhães, Eduardo Ferreira, Beatriz Marinho-Santos, Luís Pedro Afonso, André M. N. Silva, Carlos Palmeira, Francisco Amado, Andreia Peixoto, Lúcio Lara Santos, José Alexandre Ferreira   +18 more
doaj   +2 more sources

Pathogenic glycosyltransferase genes and potential therapeutic drugs in pressure overload‐induced heart failure [PDF]

ESC Heart Failure
Aims Protein glycosylation regulated by glycosyltransferases is an important type of post‐translational modification. The role of the glycosyltransferase genes (GTGs) in heart failure (HF) remains unclear and requires further investigation.
Jiahe Wu, Yi Lu, Xinchen Gao, Xiaorong Hu, Zhibing Lu, Chenze Li   +5 more
doaj   +2 more sources

Production of recombinant IgA1 with defined mucin-type O-glycans in Nicotiana tabacum BY-2 cells [PDF]

Frontiers in Plant Science
Nicotiana tabacum BY-2 cell suspension cultures are a powerful platform for producing recombinant glycoproteins such as immunoglobulins. Extensive efforts have been devoted to engineering the N-glycosylation pathway of BY-2 cells to overcome differences ...
Nicolas Bailly, Clemens Grünwald-Gruber, Marie Peeters, François Chaumont, Catherine Navarre   +4 more
doaj   +2 more sources

Hemocyte-secreted papilin bearing mucin-type O-glycans regulates peripodial stalk formation via epidermal JAK/STAT signaling in Drosophila [PDF]

iScience
Summary: Protein glycosylation is an essential post-translational modification. In evolutionarily conserved mucin-type O-glycosylation, the most common O-glycan, T antigen, is synthesized by core 1 β1,3-galactosyltransferase 1 (C1GalT1).
Takashi J. Fuwa, Kazuyoshi Itoh, Tomomi Ichimiya, Yoshihiro Akimoto, Shoko Nishihara   +4 more
doaj   +2 more sources

Cosmc loss induces truncated O-glycosylation and accelerates Kras-driven pancreatic carcinogenesis [PDF]

Neoplasia: An International Journal for Oncology Research
Aberrant mucin-type O-glycosylation is a common feature of pancreatic ductal adenocarcinoma (PDAC), yet its functional contribution to pancreatic tumorigenesis remains incompletely defined.
Baris Mercanoglu, Nina Schraps, Anastasios D. Giannou, Jingxuan Zhou, Simon Kind, Maya Reinecke, Karl-Frederick Karstens, Benjamin Dreyer, Sönke Harder, Siwen Zhang, Eleftherios D. Papazoglou, Cenap Güngör, Nathaniel Melling, Hartmut Schlüter, Christoph Wagener, Maximilian Bockhorn, Thilo Hackert, Gerrit Wolters-Eisfeld   +17 more
doaj   +2 more sources