Results 31 to 40 of about 1,608 (173)
Emerging Roles of the Unique Molecular Chaperone Cosmc in the Regulation of Health and Disease
Biomolecules, 2022 The core-1 β1-3galactosyltransferase-specific chaperone 1 (Cosmc) is a unique molecular chaperone of core-1 β1-3galactosyltransferase(C1GALT1), which typically functions inside the endoplasmic reticulum (ER).
Ting Xiang +4 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Purpose: The factor associated with IgA nephropathy (IgAN) is an abnormality of IgA known as galactose-deficient IgA1 (Gd-IgA1). The purpose of this study was to determine the molecular role played by miRNAs in the formation of Gd-IgA1 in IgAN and ...
Caiqiong Liu +14 more
doaj +1 more source
Interaction between G ALNT12 and C1GALT1 Associates with Galactose-Deficient IgA1 and IgA Nephropathy [PDF]
Journal of the American Society of Nephrology, 2021 Significance Statement Galactose-deficient IgA1 plays a key role in the pathogenesis of IgA nephropathy. Although variability in serum levels of galactose-deficient IgA1 has a strong genetic component, the genetic link between this molecule and IgA nephropathy has not yet been clearly determined.
Yan-Na Wang +9 more
openaire +2 more sources
Cell & Bioscience, 2022 Background Ammonia is the most typical neurotoxin in hepatic encephalopathy (HE), but the underlying pathophysiology between ammonia and aberrant glycosylation in HE remains unknown.
Jiajun Yang +12 more
doaj +1 more source
C1GALT1 expression predicts poor survival in osteosarcoma and is crucial for ABCC1 transporter-mediated doxorubicin resistance [PDF]
Journal of PathologyNeng-Yu Lin
exaly +2 more sources
Interaction of C1GALT1–IL5RA on the susceptibility to IgA nephropathy in Southern Han Chinese [PDF]
Journal of Human Genetics, 2012 IgA nephropathy is one of the most common glomerulonephritis throughout the world, which is thought to be the multifactorial complex diseases, with genetic and environmental factors contributing to this disease. The failure of replicating the single genes in previous association studies may be of that the gene-gene interaction might have more influence
Wei, Wang +4 more
openaire +2 more sources
Cytokines Alter IgA1 O-Glycosylation by Dysregulating C1GalT1 and ST6GalNAc-II Enzymes [PDF]
Journal of Biological Chemistry, 2014 IgA nephropathy (IgAN), the most common primary glomerulonephritis, is characterized by renal immunodeposits containing IgA1 with galactose-deficient O-glycans (Gd-IgA1). These immunodeposits originate from circulating immune complexes consisting of anti-glycan antibodies bound to Gd-IgA1.
Suzuki, Hitoshi +8 more
openaire +2 more sources
, 2017 (a) knock-down in IgA1-secreting cell lines from healthy controls; mock-control (n = 5), non-targeting siRNA (n = 7), C1GALT1 siRNA (n = 5), COSMC siRNA (n = 7), and COSMC+C1GALT1 siRNA (n = 2); (b) knock-down in IgA1-secreting cell lines from IgAN ...
Ali G. Gharavi (156930) +25 more
core +1 more source
C1GALT1 regulates cell adhesion, migration, and invasion.
, 2014 (a) Overexpression and knockdown of C1GALT1 in HCC cell lines. Overexpression of C1GALT1 with C1GALT1/pcDNA3.1 plasmid compared with pcDNA3.1 empty plasmid (mock) transfection in HCC36 and Sk-Hep1 cells.
I-Rue Lai (608592) +7 more
core +1 more source
Anti-Cancer Potential of Afzelin towards AGS Gastric Cancer Cells
Pharmaceuticals, 2021 Afzelin demonstrates anti-inflammatory and anti-cancer properties. Our purpose was to assess its influence on apoptosis, Bax, caspases, MUC1, cancer-related carbohydrate antigens, enzymes participating in their formation, and galectin-3 in AGS gastric ...
Iwona Radziejewska +4 more
doaj +1 more source