The O-glycosyltransferase C1GALT1 promotes EWSR1::FLI1 expression and is a therapeutic target for Ewing sarcoma [PDF]
Nature CommunicationsEwing sarcoma (ES) is an aggressive bone cancer driven by the oncogenic fusion-protein EWSR1::FLI1, which is not present in normal cells and is therefore an attractive therapeutic target.
Shahid Banday +11 more
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PLoS ONE, 2014 Cancer cell invasion and metastasis are the primary causes of treatment failure and death in hepatocellular carcinoma (HCC). We previously reported that core 1 β1,3-galactosyltransferase (C1GALT1) is frequently overexpressed in HCC tumors and its ...
Chiung-Hui Liu +7 more
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C1GALT1 induces the carcinogenesis of thyroid cancer through regulation by miR-141-3p and GLUT1
HeliyonCore 1 β 1,3-galactosyltransferase 1 (C1GALT1) acts as an important glycosyltransferase in the occurrence and development of tumor glycosylation. However, the regulatory mechanisms of C1GALT1 in thyroid cancer (TC) is still unclear.
Li Huang +7 more
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Acta Biochimica et Biophysica SinicaProtein glycosylation is a type of protein post-translational modification. One specific example is the modification of proteins with O-linked β-N-acetylglucosamine (O-GlcNAc) and O-linked α-N-acetylgalactosamine (O-GalNAc).
Jiang Yazhuo +4 more
doaj +5 more sources
Galactosylation of IgA1 Is Associated with Common Variation in C1GALT1. [PDF]
Journal of the American Society of Nephrology, 2017 IgA nephropathy (IgAN), an important cause of kidney failure, is characterized by glomerular IgA deposition and is associated with changes in O-glycosylation of the IgA1 molecule.
David Wimbury (7750322) +13 more
core +13 more sources
A novel mechanism for C1GALT1 in the regulation of gastric cancer progression [PDF]
Cell & Bioscience, 2021 Background Gastric cancer (GC) is a highly aggressive and lethal disease around the world. High expression of core 1 β 1, 3-galactosyltransferase 1 (C1GALT1), the primary enzyme responsible for protein O-glycosylation, plays a critical role in gastric ...
Xiaoxia Dong +7 more
doaj +3 more sources
C1GalT1 expression reciprocally controls tumour cell-cell and tumour-macrophage interactions mediated by galectin-3 and MGL with double impact on cancer development and progression [PDF]
Cell Death and Disease, 2023 Although most cell membrane proteins are modified by glycosylation, our understanding of the role and actions of protein glycosylation is still very limited.
Yangu Wan +6 more
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Abstract 5801: Loss of core 1 β1,3-galactosyltransferase (C1GALT1) in pancreatic cancer leads to altered mucin glycosylation and increased tumor aggressiveness [PDF]
Gastroenterology, 2017 Background: Aberrant expression of mucins underlie pancreatic cancer (PC) progression and metastasis. Mucin-type O-glycosylation is the principal post-translational modification on mucins and is regulated by myriad of glycosyltransferases.
Seema Chugh +7 more
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C1GALT1 expression predicts a favorable prognosis and suppresses malignant phenotypes via TrkA signaling in neuroblastoma [PDF]
Oncogenesis, 2022 Neuroblastoma (NB) is a childhood tumor derived from the sympathoadrenal lineage of the neural crest progenitor cells. Core 1 β1,3-galactosyltransferase (C1GALT1) controls the crucial step of GalNAc-type O-glycosylation, and its altered expression ...
Neng-Yu Lin +11 more
doaj +3 more sources
C1GALT1 expression is associated with galactosylation of IgA1 in peripheral B lymphocyte in immunoglobulin a nephropathy [PDF]
BMC Nephrology, 2020 Background More and more studies demonstrated that genetic variation at C1GALT1 influences Gd-IgA1 level in IgAN. However, whether the expression of β1, 3-galactosyltransferase (β1, 3Gal-T) was influenced may provide insights into how Gd-IgA1 levels are ...
Yue Xing +8 more
doaj +3 more sources