Results 21 to 30 of about 1,608 (173)

Unraveling the role of C1GALT1 in abnormal glycosylation and colorectal cancer progression

Frontiers in Oncology
C1GALT1 plays a pivotal role in colorectal cancer (CRC) development and progression through its involvement in various molecular mechanisms. This enzyme is central to the O-glycosylation process, producing tumor-associated carbohydrate antigens (TACA ...
Hong Tian, Jia-Li Yu, Xiaoli Chu, Qi Guan, Juan Liu, Ying Liu   +5 more
doaj   +3 more sources

Targeted disruption of core 1 β1,3-galactosyltransferase (C1galt1) induces apical endocytic trafficking in human corneal keratinocytes. [PDF]

PLoS ONE, 2012
Exposed mucosal surfaces limit constitutive endocytosis under physiological conditions to prevent uptake of macromolecules and pathogens and, therefore, cellular damage.
Ana Guzman-Aranguez, Ashley M Woodward, Jesús Pintor, Pablo Argüeso   +3 more
doaj   +2 more sources

Thrombycytopenia and kidney disease in mice with a mutation in the C1galt1 gene [PDF]

Proceedings of the National Academy of Sciences, 2015
An N-ethyl-N-nitrosourea mutagenesis screen in mice was performed to isolate regulators of circulating platelet number. We report here recessive thrombocytopenia and kidney disease in plt1 mice, which is the result of a severe but partial loss-of ...
Nandurkar, Harshal H., Kauppi, Maria, Croker, Ben A, Stevenson, William, Nicola, Nicos A, Alexander, Warren S, Roberts, Andrew A, Viney, Elizabeth M., Selan, Carly, Carpinelli, Marina R, Metcalf, Donald, Hyland, Craig D, Ellis, Sarah, Kile, Benjamin T, Hilton, Douglas J, Zhang, Jian-Guo, Hilton, Adrienne A, Goodnow, Christopher   +17 more
core   +4 more sources

Additional file 1 of A novel mechanism for C1GALT1 in the regulation of gastric cancer progression

, 2021
Additional file 1: Figure S1. Scatter diagrams for C1GALT1 expression versus transcription factors expression in GC samples based on the TCGA and GTEx databases. Figure S2. Effect of SP1 on C1GALT1 expression. C1GALT1 mRNA levels were detected by qRT-PCR.
Xiaoxia Dong (6666980), Zhen Peng (539724), Xinzhou Deng (9587581), Zhiguo Luo (817528), Li Shen (11350576), Chunli Chen (176508), Qiwen Duan (9587587), Yongyu Liu (11086830)   +7 more
core   +2 more sources

Up-regulation of C1GALT1 promotes breast cancer cell growth through MUC1-C signaling pathway

Oncotarget, 2017
Aberrant glycosylation is frequently observed in cancers. Core 1 beta 1,3-galactosyltransferase (C1GALT1) is an exclusive enzyme in humans that catalyzes the biosynthesis of core 1 O-glycan structure, Gal-GalNAc-O-Ser/Thr, whose expression is commonly up-
Chou, Chih-Hsing;Huang, Miao-Juei;Chen, Chi-Hau;Shyu, Ming-Kwang;Huang, John;Hung, Ji-Shiang;Huang, Chiun-Sheng;Huang, Min-Chuan, 陳啟豪;黃敏銓;徐明洸;洪基翔;黃俊升;黃約翰, 黃敏銓, Chou, Chih-Hsing; Huang, Miao-Juei; Chen, Chi-Hau; Shyu, Ming-Kwang; Huang, John; Hung, Ji-Shiang; Huang, Chiun-Sheng; Huang, Min-Chuan   +3 more
core   +4 more sources

Dismissing-then-recruiting: a unique mechanism for symbiont recruitment and lignocellulose degradation in gut of black soldier fly larvae [PDF]

Microbiome
Background Black soldier fly larvae (Hermetia illucens L., BSFL) efficiently degrade lignocellulosic waste despite lacking endogenous lignocellulolytic enzymes, indicating a critical dependence on gut-associated microbiota.
Fang Ming Xiang, Xiao Tian Tang, María Gómez Brandón, Ahmed R. Henawy, ShuoYun Jiang, XinHua Xu, XueXin Chen, ZhiJian Zhang   +7 more
doaj   +2 more sources

Dioscin attenuates Gd-IgA1 overproduction by inhibiting the IL-6-JAK2/STAT3 signaling axis in IgA nephropathy [PDF]

BMC Nephrology
Background Inflammation is a key driver in IgA nephropathy (IgAN) pathogenesis. Recent studies have demonstrated a significant association between pro-inflammatory cytokine–triggered inflammatory cascades, particularly those involving interleukin-6 (IL-6)
Lan Lin, HuiMei Li, ShiQiang Zhou, LiHua Zheng, ShiPeng Sun, Shen Li   +5 more
doaj   +2 more sources

C1GALT1 in health and disease (Review)

Oncology Letters, 2021
O-linked glycosylation (O-glycosylation) and N-linked glycosylation (N-glycosylation) are the two most important forms of protein glycosylation, which is an important post-translational modification. The regulation of protein function involves numerous mechanisms, among which protein glycosylation is one of the most important.
Sun, Xiaojie, Zhan, Mengru, Sun, Xun, Liu, Wanqi, Meng, Xiangwei   +4 more
openaire   +3 more sources

Update on the role of C1GALT1 in cancer (Review)

Oncology Letters, 2022
Cancer remains one of the most difficult diseases to treat. In the quest for early diagnoses to improve patient survival and prognosis, targeted therapies have become a hot research topic in recent years. Glycosylation is the most common posttranslational modification in mammalian cells.
Xia, Tong, Xiang, Ting, Xie, Hailong
openaire   +3 more sources

Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer

Journal of Experimental & Clinical Cancer Research, 2022
Background Abnormal glycosylation in a variety of cancer types is involved in tumor progression and chemoresistance. Glycosyltransferase C1GALT1, the key enzyme in conversion of Tn antigen to T antigen, is involved in both physiological and pathological ...
Zengqi Tan, Yazhuo Jiang, Liang Liang, Jinpeng Wu, Lin Cao, Xiaoman Zhou, Zhihui Song, Zhenyu Ye, Ziyan Zhao, Hui Feng, Zewen Dong, Shuai Lin, Zhangjian Zhou, Yili Wang, Xiang Li, Feng Guan   +15 more
doaj   +1 more source