Results 51 to 60 of about 1,608 (173)

Exposure of Keratinocytes to Candida Albicans in the Context of Atopic Milieu Induces Changes in the Surface Glycosylation Pattern of Small Extracellular Vesicles to Enhance Their Propensity to Interact With Inhibitory Siglec Receptors

Frontiers in Immunology, 2022
Candida albicans (C. albicans) infection is a potential complication in the individuals with atopic dermatitis (AD) and can affect clinical course of the disease.
Adrian Kobiela, Joanna E. Frackowiak, Anna Biernacka, Lilit Hovhannisyan, Aleksandra E. Bogucka, Kinga Panek, Argho Aninda Paul, Joanna Lukomska, Xinwen Wang, Xinwen Wang, Eleni Giannoulatou, Aleksandra Krolicka, Jacek Zielinski, Milena Deptula, Milena Deptula, Michal Pikula, Susanne Gabrielsson, Susanne Gabrielsson, Graham S. Ogg, Danuta Gutowska-Owsiak, Danuta Gutowska-Owsiak   +20 more
doaj   +1 more source

The Critical Role of GALNTs‐Regulated O‐GalNAc Glycosylation in Cancer Malignancy

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
The GALNT family initiates mucin‐type O‐GalNAc glycosylation in the Golgi apparatus and how regulatory mechanisms, including GALNT relocalization and microRNA control, modulate this process. Dysregulated O‐GalNAc glycosylation alters key cellular behaviors and promotes cancer malignancy, highlighting its relevance to tumor progression as well as its ...
Jiahao Liu, Sihan Wu, Ge Zhang, Jiehan Li, Yuhan Yin, Aman Uiiah, Sanfei Peng, Yang Fu   +7 more
wiley   +1 more source

C1GALT1 modifies O-glycans on integrin β1.

, 2014
(a) Integrin β1 carried O-glycans in HCC cells. Lysates of HA22T cells (0.5 mg) were treated with neuraminidase (Neu) and/or PNGaseF and then pulled down (PD) by PNA agarose beads.
I-Rue Lai (608592), Yao-Ming Wu (386205), Chia-Hua Chen (234886), Hong-Shiee Lai (301362), Min-Chuan Huang (281425), Rey-Heng Hu (135326), Chiung-Hui Liu (291005), Miao-Juei Huang (281421)   +7 more
core   +1 more source

GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Aberrant glycosylation drives cancer progression, yet its role in the tumor microenvironment remains unclear. We developed GlycoChat to map glycan–lectin circuits at single‐cell resolution. We discovered that cancer cells induce immunosuppressive macrophage differentiation and impair phagocytosis through interactions with CLEC10A and SIGLEC3 ...
Dinh Xuan Tuan Anh, Sunanda Keisham, Arun Burramsetty, Lalhaba Oinam, Koichiro Kumano, Akihiro Kuno, Osamu Shimomura, Tatsuya Oda, Hiroaki Tateno   +8 more
wiley   +1 more source

GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway.

PLoS Genetics, 2017
Aberrant O-glycosylation of serum immunoglobulin A1 (IgA1) represents a heritable pathogenic defect in IgA nephropathy, the most common form of glomerulonephritis worldwide, but specific genetic factors involved in its determination are not known.
Krzysztof Kiryluk, Yifu Li, Zina Moldoveanu, Hitoshi Suzuki, Colin Reily, Ping Hou, Jingyuan Xie, Nikol Mladkova, Sindhuri Prakash, Clara Fischman, Samantha Shapiro, Robert A LeDesma, Drew Bradbury, Iuliana Ionita-Laza, Frank Eitner, Thomas Rauen, Nicolas Maillard, Francois Berthoux, Jürgen Floege, Nan Chen, Hong Zhang, Francesco Scolari, Robert J Wyatt, Bruce A Julian, Ali G Gharavi, Jan Novak   +25 more
doaj   +1 more source

Abstract 359: C1GALT1 activates multiple RTKs and promotes malignant behaviors in pancreatic adenocarcinoma cells

, 2017
Pancreatic adenocarcinoma (PDAC), stands up to the 4th in all cancer mortalities and remains the most in progress in America. Curative resection remains the most and only potential strategy but only 15~20% of patients are candidates. Even though, many of
Hsueh-Fen Juan, Min-Chuan Huang, Yu-Wen Tien, Ting-Chun Kuo   +3 more
core   +1 more source

Autoantibodies Specific for Galactose-Deficient IgA1 in IgA Vasculitis With Nephritis

Kidney International Reports, 2019
Introduction: Patients with IgA nephropathy (IgAN) have elevated serum levels of galactose-deficient IgA1 (Gd-IgA1) that are bound by Gd-IgA1–specific autoantibodies in pathogenic immune complexes. Renal biopsy histopathologic features of IgA vasculitis (
Hitoshi Suzuki, Zina Moldoveanu, Bruce A. Julian, Robert J. Wyatt, Jan Novak   +4 more
doaj   +1 more source

Identification of β‐galactosidases along the secretory pathway of Nicotiana benthamiana that collectively hamper engineering of galactose‐extended glycans on recombinant glycoproteins

Plant Biotechnology Journal, Volume 24, Issue 1, Page 224-238, January 2026.
Summary Glycosylation is an important aspect for many biopharmaceuticals, including vaccines against parasitic helminths. Plants, especially Nicotiana benthamiana, have proven to be excellent production hosts for biopharmaceuticals with tailor‐made glycosylation.
Alex van der Kaaij, Myrna J. M. Bunte, Lisa Nijhof, Sanaz Mokhtari, Hein Overmars, Arjen Schots, Ruud H. P. Wilbers, Pieter Nibbering   +7 more
wiley   +1 more source

Deciphering the Underlying Mechanisms Linking Psoriasis and IgA Nephropathy

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Psoriasis is a chronic, immune‐mediated inflammatory disease with systemic manifestations that include renal complications. Immunoglobulin A nephropathy (IgAN) represents the most common autoimmune glomerular disease worldwide. Growing epidemiological and genetic evidence supports a clinically relevant association between psoriasis and IgAN ...
Zijie Tang, Jintong Wu, Meihan Dong, Chengxin Li, Rui Wang, Poorani Gurumallesh Prabu   +5 more
wiley   +1 more source

Interleukin-17 promotes the production of underglycosylated IgA1 in DAKIKI cells

Renal Failure, 2018
Background: Interleukin 17 (IL-17) plays an important role in the pathogenesis of autoimmune diseases and might be associated with IgA nephropathy (IgAN).
Jia-Ru Lin, Ji Wen, Hui Zhang, Li Wang, Fang-Fang Gou, Man Yang, Jun-Ming Fan   +6 more
doaj   +1 more source